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Title: US5667811: Na-K-ATPase inhibiting natriuretic substances
[ Derwent Title ]

Country: US United States of America

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34 pages

 
Inventor: Gonick, Harvey C.; Los Angeles, CA
Weiler, Elmar; Inglewood, CA
Khalil-Manesh, Farhad; Los Angeles, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1997-09-16 / 1992-11-30

Application Number: US1992000983617
IPC Code: Advanced: C07K 4/12; C07K 14/47; C07K 16/18; A61K 38/00;
Core: C07K 4/00; C07K 14/435; more...
IPC-7: A61K 35/14; A61K 35/16;

ECLA Code: C07K4/12;

U.S. Class: Current: 424/530; 424/529; 424/531;
Original: 424/530; 424/529; 424/531;

Field of Search: 424/536,531,545,530 530/830,834

Priority Number:
1992-11-30  US1992000983617
1990-09-11  US1990000581582

Abstract: The invention provides methods for obtaining substantially purified high and low molecular weight Na-K-ATPase inhibitor compounds having natriuretic and vasoconstrictive activity, antibodies reactive with the compounds and methods for their use in diagnostic and therapeutic applications to detect elevated or decreased amounts of the compounds in subjects having diseases associated with the presence or deficiency of these natriuretic compounds.

Attorney, Agent or Firm: Merchant, Gould, Smith, Edell, Welter & Schmidt ;

Primary / Asst. Examiners: Davenport, Avis M.;

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Application Number Filed Patent Pub. Date  Title
US1990000581582 1990-09-11       


       
Parent Case:     This is a continuation of copending application Ser. No. 07/581,582 filed on Sep. 11, 1990 and now abandoned.

Designated Country: AT BE CH DE DK ES FR GB GR IT LI LU NL SE  AU CA EP JP KR OA 

Family: Show 13 known family members
Claim We claim:     1. A substantially pure isolated low molecular weight plasma inhibitor of Na-K-ATPase occurring in human plasma and characterized by having vasoconstrictive and natriuretic activity and displacing ouabain from its receptor and lacking reactivity with anti-digoxin antibody, said inhibitor having a molecular weight of less than 500 peptide.

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U.S. References: Go to Result Set: All U.S. references   |  No patents reference this one   |   Backward references (10)   |   Citation Link

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PDF		 Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 24pp US4321120  1982-03 Nardi et al.   Process for detecting proteins specific to hypertension in mammals
Buy PDF- 13pp US4665019  1987-05 Hamlyn et al.  University of Maryland Method for measuring the plasma levels of an inhibitor of (Na+ +K+
Buy PDF- 6pp US4727061  1988-02 Kramer et al.  Rohm GmbH Pharmaceutical preparations having diuretic activity
Buy PDF- 5pp US4746652  1988-05 Buckalew, Jr. et al.  Wake Forest University Method of inducing diuresis with lysophospholipids
Buy PDF- 8pp US4780314  1988-10 Graves  Brigham and Women's Hospital Isolation and purification of a digitalis-like factor
Buy PDF- 10pp US4780410  1988-10 Matsuda et al.  Eisai Co., Ltd. Sandwich enzyme immunoassay for PIVKA-II with monoclonal anti-PIVKA-II antibody
Buy PDF- 9pp US4782014  1988-11 Serban et al.  Ciba-Geigy Corporation Assay and purification of amyloid components, applications, and kits therefor
Buy PDF- 12pp US4940670  1990-07 Rhodes   Method for compounding and testing patient specific monoclonal antibodies and monoclonal antibody fragments for in vivo use
Buy PDF- 11pp US4940782  1990-07 Rup et al.  G. D. Searle & Co. Monoclonal antibodies against IgE-associated determinants, hybrid cell lines producing these antibodies, and use therefore
Buy PDF- 11pp US4943533  1990-07 Mendelsohn et al.  The Regents of the University of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
       
Foreign References:
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PDF		 Publication Date IPC Code Assignee   Title
Buy PDF FR2597483 1987-10  A61K 38/00 FLORK MICHEL NOUVEAUX PEPTIDES DIURETIQUES ET NATRIURETIQUES. 


Other Abstract Info: CHEMABS 117(09)083448K DERABS C92-131882

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