 |
|
|
|
|
|
 Title: |
US5670622:
Conotoxin peptide PIIIA
[ Derwent Title ]
|
| Country: |
US United States of America
|
| |
| Inventor: |
Shon, Ki-Joon; Salt Lake City, UT
Yoshikami, Doju; Salt Lake City, UT
Marsh, Maren; Salt Lake City, UT
Cruz, Lourdes J.; Salt Lake City, UT
Hillyard, David R.; Salt Lake City, UT
Olivera, Baldomero M.; Salt Lake City, UT
|
| Assignee: |
University of Utah Research Foundation, Salt Lake City, UT
other patents from UNIVERSITY OF UTAH RESEARCH FOUNDATION (600050) (approx. 286)
News, Profiles, Stocks and More about this company
|
| Published / Filed: |
1997-09-23
/ 1996-02-15
|
| Application Number: |
US1996000599556
|
| IPC Code: |
Advanced:
C07K 14/435;
A61K 38/00;
Core:
more...
IPC-7:
C07K 14/00;
|
| ECLA Code: |
C07K14/435;
|
| U.S. Class: |
Current:
530/324;
530/325;
530/326;
530/327;
530/855;
Original:
530/324;
530/325;
530/326;
530/855;
530/327;
|
| Field of Search: |
530/300,324,326,325,855
|
| Priority Number: |
| 1996-02-15 |
US1996000599556 |
|
| Abstract: |
The invention is directed to a new µ-conotoxin named GIIIA. µ-Conotoxin PIIIA consists of 22 amino residues and is found in the Eastern Pacific fish-hunting species Conus purpurascens. This conotoxin is a new Na+ channel blocker and can be used to resolve tetrodotoxin-sensitive sodium channels into three categories: 1) sensitive to µ-PIIIA and µ-conotoxin GIIIA; 2) sensitive to µ-PIIIA but not to µ-GIIIA; and 3) sensitive to neither of these two µ-conotoxins. In rat brain, binding competition studies between the two µ-conotoxins and saxitoxin suggest at least three pharmacologically distinguishable binding sites. Thus, µ-conotoxin PIIIA should be a key tool for distinguishing among different sodium channel subtypes.
|
| Attorney, Agent or Firm: |
Venable, Baetjer, Howard & Civiletti, LLP ;
|
| Primary / Asst. Examiners: |
Adams, Donald E.; Krikorian, Jacqueline G.
|
| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
|
| Designated Country: |
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE AU CA EP JP
|
| Family: |
Show 11 known family members
|
First Claim:
Show all 6 claims |
What is claimed is:
1. An isolated, or purified µ-conotoxin consisting of the amino acid sequence Xaa1 -Arg-Leu-Cys-Cys-Gly-Phe-Xaa2 -Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys-Xaa2 -His-Arg-Cys-Cys (SEQ ID NO: 1) where Xaa1 is pyroglutamate or glutamine and Xaa2 is 4-trans-hydroxyproline or proline.
|
| Background / Summary: |
Show background / summary
|
| Drawing Descriptions: |
Show drawing descriptions
|
| Description: |
Show description
|
| Forward References: |
Show 12 U.S. patent(s) that reference this one
|
|
|
|
|
|
|
| Foreign References: |
|
| Other Abstract Info: |
DERABS C1996-485724
|
| Other References: |
Colledge, C.J. et al. (1992). "Precursor Structure of ω-Conotoxin GVIA Determined from a cDNA Clone," Toxicon 30:1111-1116.
(6 pages)
Cited by 4 patents
[ISI abstract]
Cruz, L.J. and Olivera, B.M. (1986). "Calcium Channel Antagonists. ω-Conotoxin Defines a New High Affinity Site," J. Biol. Chem. 261:6230-6233.
(4 pages)
Cited by 4 patents
Dudley, S.C. et al. (1995). "A µ-Conotoxin-Insensitive Na+ Channel Mutant: Possible Localization of a Binding Site at the Outer Vestibule," Biophysical J. 69:1657-1665.
(9 pages)
Cited by 3 patents
[ISI abstract]
Fainzilber, M. et al. (1991). "Mollusc-specific toxins from the venom of Conus textile neovicarius," Eur. J. Biochem. 202:589-595.
(7 pages)
Cited by 7 patents
[ISI abstract]
Fainzilber, M. et al. (1994). "A New Neurotoxin Receptor Site on Sodium Channels Is Identified by a Conotoxin That Affects Sodium Channel Inactivation in Molluscs and Acts as an Antagonist in Rat Brain," J. Biol. Chem. 269:2574-2580.
(7 pages)
Cited by 4 patents
[ISI abstract]
Fainzilber, M. et al. (1994). "New Mollusc-Specific α-Conotoxins Block Aplysia Neuronal Acetylcholine Receptors," Biochemistry 33:9523-9529.
(7 pages)
Cited by 5 patents
[ISI abstract]
Gray, W.R. et al. (1981). "Peptide Toxins from Conus geographus Venom," J. Biol. Chem. 256:4734-4740.
(7 pages)
Cited by 14 patents
Hasson, A. et al. (1993). "Alteration of Sodium Currents by New Peptide Toxins From the Venom of a Molluscivorous Conus Snail," Eur. J. Neurosci. 5:56-64.
(9 pages)
Cited by 3 patents
[ISI abstract]
Hillyard, D.R. et al. (1989). "A Molluscivorous Conus Toxin: Conserved Frameworks in Conotoxins," Biochemistry 28:358-361.
(4 pages)
Cited by 13 patents
Hillyard, D.R. et al. (1992). "A New Conus Peptide Ligand for Mammalian Presynaptic Ca2+ Channels," Neuron 9:69-77.
(9 pages)
Cited by 4 patents
[ISI abstract]
Hopkins, C. et al. (1995). "A New Family of Conus Peptides Targeted to the Nicotinic Acetylcholine Receptor," J. Biol. Chem. 270:22361-22367.
(7 pages)
Cited by 3 patents
[ISI abstract]
Kobayashi, J. et al. (1982). "Isolation of a Cardiotonic Glycoprotein, Striatoxin, from the Venom of the Marine Snail Conus Striatus," Biochem. Biophys. Res. Comm. 105:1389-1395.
(7 pages)
Cited by 3 patents
Lundy, P.M. et al. (1991). "Pharmacological evidence for an ω-conotoxin, dihydropyridine-insensitive neuronal Ca2+ channel," Eur. J. Pharmacol. 206:61-68.
(8 pages)
Cited by 4 patents
[ISI abstract]
McCleskey, E.W. et al. (1987). "ω-Conotoxin: Direct and persistent blockade of specific types of calcium channels in neurons but not muscle," Proc. Natl. Acad. Sci. USA 84:4327-4331.
(5 pages)
Cited by 8 patents
McIntosh, M. et al. (1982). "Isolation and Structure of a Peptide Toxin from the Marine Snail Conus magus," Arch. Biochem. Biophys. 218:329-334.
(6 pages)
Cited by 8 patents
McIntosh, J.M. et al. (1995). "A New Family of Conotoxins That Blocks Voltage-gated Sodium Channels," J. Biol. Chem. 270:16796-16802.
(7 pages)
Cited by 3 patents
[ISI abstract]
Monje, V.D. et al. (1993). "A New Conus Peptide Ligand For Ca Channel Subtypes," Neuropharmacology 32:1141-1149.
(9 pages)
Cited by 10 patents
[ISI abstract]
Myers, R.A. et al. (1993). "Conus Peptides as Chemical Probes for Receptors and Ion Channels," Chem, Rev. 93:1923-1936.
(14 pages)
Cited by 14 patents
[ISI abstract]
Olivera, B.M. et al. (1984). "Purification and Sequence of a Presynaptic Peptide Toxin from Conus geographus Venom," Biochemistry 23:5087-5090.
(4 pages)
Cited by 13 patents
Olivera, B.M. et al. (1985). "Peptide Neurotoxins from Fish-Hunting Cone Snails," Science 230:1338-1343.
(6 pages)
Cited by 25 patents
Olivera, B.M. et al. (1987). "Neuronal Calcium Channel Antagonists. Discrimination between Calcium Channel Subtypes Using ω-Conotoxin from Conus magus Venom," Biochemistry 26:2086-2090.
(5 pages)
Cited by 19 patents
Olivera, B.M. et al. (1990). "Diversity of Conus Neuropeptides," Science 249:257-263.
(7 pages)
Cited by 36 patents
Olivera, B.M. et al. (1991). "Conotoxins," J. Biol. Chem. 266:22067-22070.
(4 pages)
Cited by 30 patents
[ISI abstract]
Ramilo, C.A. et al. (1992). "Novel α-and ω-Conotoxins from Conus striatus Venom," Biochemistry 31:9919-9926.
(8 pages)
Cited by 5 patents
[ISI abstract]
Regan, L.J. et al. (1991). "Ca2+ Channels in Rat Central and Peripheral Neurons: High-Threshold Current Resistant to Dihydropyridine Blockers and ω-Conotoxin," Neuron 6:269-280.
(12 pages)
Cited by 3 patents
[ISI abstract]
Rivier, J. et al. (1987). "Neuronal Calcium Channel Inhibitors. Synthesis of ω-Conotoxin GVIA and Effects on 45 Ca Uptake by Synaptosomes," J. Biol. Chem. 262:1194-1198.
(5 pages)
Cited by 11 patents
Shon, K-J. et al. (1994). "δ-Conotoxin GmVIA, a Novel Peptide from the Venom of Conus gloriamaris," Biochemistry 33:11420-11425.
(6 pages)
Cited by 4 patents
[ISI abstract]
Shon, K-J. et al. (1995). "Purification, Characterization, Synthesis, and Cloning of the Lockjaw Peptide from Conus purpurascens Venom," Biochemistry 34:4913-4918.
(6 pages)
Cited by 3 patents
[ISI abstract]
Spira, M.E. et al. (1993). "Chemical and Electrophysiological Characterization of New Peptide Neurotoxins from the Venom of the Molluscivorous Snail Conus textile neovicarius: A Review," Isr. J. Med. Sci. 29:530-543.
(14 pages)
Cited by 3 patents
[ISI abstract]
Woodward, S.R. et al. (1990). "Constant and hypervariable regions in conotoxin propeptides," EMBO J. 9:1015-1020.
(6 pages)
Cited by 10 patents
Yoshikami, D. et al. (1989). "The Inhibitory Effects of Omega-Conotoxins on Ca Channels and Synapses," Ann. N.Y. Acad. Sci. 560:230-248.
(19 pages)
Cited by 4 patents
|
|
 Nominate this for the Gallery...
|
|
