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Title: US5672682: Conotoxin peptide PVIIA
[ Derwent Title ]

Country: US United States of America

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15 pages

 
Inventor: Terlau, Heinrich; Gottingen, Germany
Shon, Ki-Joon; Salt Lake City, UT
Grilley, Michelle; Salt Lake City, UT
Olivera, Baldomero M.; Salt Lake City, UT

Assignee: University of Utah Research Foundation, Salt Lake City, UT
other patents from UNIVERSITY OF UTAH RESEARCH FOUNDATION (600050) (approx. 286)
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Published / Filed: 1997-09-30 / 1996-03-18

Application Number: US1996000619936
IPC Code: Advanced: C07K 14/435; A61K 38/00;
Core: more...
IPC-7: C07K 14/00; C07K 14/435;

ECLA Code: C07K14/435A;

U.S. Class: Current: 530/324; 530/300;
Original: 530/324; 530/300; 530/321;

Field of Search: 530/300,317,324 514/002,9,12

Government Interest:     This invention was made with Government support under Grant No. PO1 GM 28677 from the National Institute of General Medical Sciences of the National Institutes of Health, Bethesda, Md. The United States Government has certain rights in the invention.

Priority Number:
1996-03-18  US1996000619936

Abstract: A new peptide, .kappa.-conotoxin PVIIA, is disclosed. This peptide is found naturally in the cone snail Conus purpurascens and has the amino acid sequence Cys-Arg-Ile-Xaa-Asn-Gln-Lys-Cys-Phe-Gln-His-Leu-Asp-Asp-Cys-Cys-Ser-Arg-Lys-Cys-Asn-Arg-Phe-Asn-Lys-Cys-Val (SEQ ID NO:1) where Xaa represents 4-trans-hydroxyproline hydroxyproline or proline. This peptide together with a previously disclosed peptide, δ-conotoxin PVIA, act synergistically to rapidly immobilize fish which are injected with the two peptides. Injection of .kappa.-conotoxin PVIIA alone results in different symptoms with an injected fish becoming hyperactive and then contracting and suddenly extending all major fins. This "fin-popping" occurs repeatedly resulting in a series of jerky movements, but injection of only .kappa.-conotoxin PVIIA does not immobilize or kill the fish.

Attorney, Agent or Firm: Venable, Baetjer, Howard & Civiletti, LLP ;

Primary / Asst. Examiners: Allen, Marianne P.; Duffy, Patricia A.
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Designated Country: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE  AU CA EP JP 

Family: Show 15 known family members
First Claim:
Show all 3 claims		 What is claimed is:     1. A substantially pure .kappa.-conotoxin peptide consisting of the amino acid sequence Cys-Arg-Ile-Xaa-Asn-Gln-Lys-Cys-Phe-Gln-His-Leu-Asp-Asp-Cys-Cys-Ser-Arg-Lys-Cys-Asn-Arg-Phe-Asn-Lys-Cys-Val (SEQ ID NO:1) where Xaa represents 4-trans-hydroxyproline.

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Forward References: Show 6 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (6)   |   Backward references (8)   |   Citation Link

Buy
PDF		 Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 10pp US4447356  1984-05 Olivera et al.   Conotoxins
Buy PDF- 29pp US5051403  1991-09 Miljanich et al.  Neurex Corporation Method of treating ischemia-related neuronal damage
Buy PDF- 32pp US5189020  1993-02 Miljanich et al.  Neurex Corporation Method of reducing neuronal damage using omega conotoxin peptides
Buy PDF- 31pp US5264371  1993-11 Miljanich et al.  Neurex Corporation Screening method for neuroprotective compounds
Buy PDF- 31pp US5424218  1995-06 Miljanich et al.  Neurex Corporation Screening method for neuroprotective compounds
Buy PDF- 15pp US5432155  1995-07 Olivera et al.  The Salk Institute For Biological Studies Conotoxins I
Buy PDF- 32pp US5514774  1996-05 Olivera et al.  University of Utah Research Foundation Conotoxin peptides
Buy PDF- 36pp US5589340  1996-12 Olivera et al.  University of Utah Research Foundation Process and primers for identifying nucleic acids encoding A-lineage conotoxin peptides
       
Foreign References:
Buy
PDF		 Publication Date IPC Code Assignee   Title
Buy PDF- 105pp WO9310145 1993-05  A61K 38/00 BITNER, Robert, S. COMPOSITIONS FOR DELAYED TREATMENT OF ISCHEMIA-RELATED NEURONAL DAMAGE 
Buy PDF- 92pp WO9313128 1993-07  A61K 38/00 GOHIL, Kishor, Chandra METHODS OF PRODUCING ANALGESIA AND ENHANCING OPIATE ANALGESIA 
Buy PDF- 67pp WO9511256 1995-04  C07K 7/08 UNIVERSITY OF UTAH RESEARCH FOUNDATION CONOTOXIN PEPTIDES 


Other Abstract Info: CHEMABS 127(20)274085F

Other References:
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  • Dudley, S.C. et al. (1995). "A µ-Conotoxin-Insensitive Na+ Channel Mutant: Possible Localization of a Binding Site at the Outer Vestible," Biophysical J. 69:1657-1665. (9 pages) Cited by 3 patents [ISI abstract]
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  • Fainzilber, M. et al. (1994). "A New Neurotoxin Receptor Site on Sodium Channels Is Identified by a Conotoxin That Affects Sodium Channel Inactivation in Molluscs and Acts as an Antagonist in Rat Brain," J. Biol. Chem. 269:2574-2580. (7 pages) Cited by 4 patents [ISI abstract]
  • Fainzilber, M. et al. (1994). "New Mollusc-Specific α-Conotoxins Block Aplysia Neuronal Acetylcholine Receptors," Biochemistry, 33:9523-9529. (7 pages) Cited by 5 patents [ISI abstract]
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  • Monje, V.D. et al. (1993). "A New Conus Peptide Ligand For Ca Channel Subtypes," Neuropharmacology 32:1141-1149. (9 pages) Cited by 10 patents [ISI abstract]
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  • Olivera, B.M. et al. (1985). "Peptide Neurotoxins from Fish-Hunting Cone Snails," Science 230:1338-1343. (6 pages) Cited by 25 patents
  • Olivera, B.M. et al. (1987). "Neuronal calcium Channel Antagonists. Discrimination between Calcium Channel Subtypes Using ω-Conotoxin from Conus magus Venom," Biochemistry 26:2086-2090. (5 pages) Cited by 19 patents
  • Olivera, B.M. et al. (1990). "Diversity of Conus Neuropeptides," Science 249:257-263. (7 pages) Cited by 36 patents
  • Olivera, B.M. et al. (1991). "Conotoxins," J. Biol. Chem. 266:22067-22070. (4 pages) Cited by 30 patents [ISI abstract]
  • Ramilo, C.A. et al. (1992). "Novel α-and ω-Conotoxins from Conus striatus Venom," Biochemistry 31:9919-9926. (8 pages) Cited by 5 patents [ISI abstract]
  • Regan, L.J. et al. (1991). "Ca2+ Channels in Rat Central and Peripheral Neurons: High-Threshold Current Resistant to Dihydropyridine Blockers and ω-Conotoxin," Neuron 6:269-280. (12 pages) Cited by 3 patents [ISI abstract]
  • Rivier, J. et al. (1987). "Neuronal Calcium Channel Inhibitors. Synthesis of ω-Conotoxin GVIA and Effects on 45 Ca Uptake by Synaptosomes," J. Biol. Chem. 262:1194-1198. (5 pages) Cited by 11 patents
  • Shon, K-J. et al. (1994). "δ-Conotoxin GmVIA, a Novel Peptide from the Venom of Conus gloriamaris," Biochemistry 33:11420-11425. (6 pages) Cited by 4 patents [ISI abstract]
  • Shon, K-J. et al. (1995). "Purification, Characterization, Synthesis, and Cloning of the Lockjaw Peptide from Conus purpurascens Venom," Biochemistry 34:4913-4918. (6 pages) Cited by 3 patents [ISI abstract]
  • Spira, M.E. et al. (1993). "Chemical and Electrophysiological Characterization of New Peptide Neurotoxins from the Venom of the Molluscivorous Snail Conus textile neovicarius: A Review," Isr. J. Med. Sci. 29:530-543. (14 pages) Cited by 3 patents [ISI abstract]
  • Woodward, S.R. et al. (1990). "Constant and hypervariable regions in conotoxin propeptides," EMBO J. 9:1015-1020. (6 pages) Cited by 10 patents
  • Yoshikami, D. et al. (1989). "The Inhibitory Effects of Omega-Conotoxins on Ca Channels and Synapses," Ann. N.Y. Acad. Sci. 560:230-248. (19 pages) Cited by 4 patents
  • Teralu et al (1996). "Strategy For Rapid Immobilization of Prey by a Fish-Hunting Marine Snail," Nature 381:148-151.


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