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Title: US5674978: Peptides derived from glutamic acid decarboxylase
[ Derwent Title ]


Country: US United States of America

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39 pages

 
Inventor: Tobin, Allan J.; Los Angeles, CA
Erlander, Mark G.; Tarzana, CA
Kaufman, Daniel L.; Santa Monica, CA
Clare-Salzler, Michael J.; Gainesville, FL

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1997-10-07 / 1993-09-17

Application Number: US1993000123859

IPC Code: Advanced: C12N 9/88; G01N 33/564; A61K 38/00; A61K 39/00;
Core: more...
IPC-7: C07K 7/00; C07K 14/435; C12N 9/88;

ECLA Code: C12N9/88; G01N33/564; K61K38/00; K61K39/00; M12N203/00; M12N207/00; M12N215/00; M12Q220/114F35; M12Q220/120; S01N800/04A; S01N800/24;

U.S. Class: Current: 530/326; 435/232; 530/327; 530/328; 530/329; 530/330;
Original: 530/326; 530/377; 530/328; 530/329; 530/330; 435/232;

Field of Search: 435/232 530/324-329,403,330 930/240

Government Interest:     The present invention was supported by Grant NS22256 from the National Institutes of Health. The United States Government has certain rights in this invention.

Priority Number:
1993-09-17  US1993000123859

Abstract:     Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.

Attorney, Agent or Firm: Flehr Hohbach Test Albritton & Herbert LLP ;

Primary / Asst. Examiners: Hendricks, Keith D.;

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Related Applications: Go to Result Set: 3 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1991000716909 1991-06-18       
US1990000586536 1990-09-21       


       
Parent Case:     This application is a continuation-in-part application of U.S. Ser. No. 07/716,909, filed Jun. 18, 1991, now abandoned, which is a continuation-in-part application of U.S. Ser. No. 07/586,536, filed Sep. 21, 1990.

Designated Country: BE CH FR GB IT LI LU MC NL PT SE  IE  NO 

Family: Show 68 known family members

First Claim:
Show all 8 claims
We claim:     1. A composition comprising a peptide consisting of an amino acid sequence selected from the group consisting of
  • KPCSCSKVDVNYAFLHATDL;
  • TAGTTVYGAFDPLLAVADICKK;
  • EYLYNIIKNREGYEMVFDGK;
  • IPPSLRTLEDNEERMSRLSK;
  • SRLSKVAPVIKARMMEYGTT;
  • EYGTTMVSYQPLGDKVNFFR;
  • ATHQDIDFLIEEIERLGQDL;
  • LAFLQDVMNILLQYVVKSFDRS;
  • EEILMHCQTTLKYAIKTGHP;
  • DERGKMIPSDLERRILEAKQ;
  • KHYDLSYDTGDKALQCGRHV;
  • AALGIGTDSVILIKCDERGK;
  • GLLMSRKHKWKLSGVERANS;
  • LEAKQKGFVPFLVSATAGTT; and
  • VNFFRMVISNPAATHQDIDF.


Background / Summary: Show background / summary

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Description: Show description

Forward References: Show 10 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (10)   |   Backward references (4)   |   Citation Link

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PDF
Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 5pp US4487830  1984-12 Coates et al.  American Hoechst Corporation Enzyme/immunofluorescent assay for autoantibodies
Buy PDF- 49pp US4624926  1986-11 Inouye et al.  The Research Foundation of State University of New York Novel cloning vehicles for polypeptide expression in microbial hosts
Buy PDF- 18pp US4751181  1988-06 Keene  Duke University Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
Buy PDF- 11pp US5200318  1993-04 Rabin et al.  Miles Inc. Diagnosis of IDDM with a panel of immunoreagents
       
Foreign References:
Buy
PDF
Publication Date IPC Code Assignee   Title
Buy PDF- 55pp WO9007117 1990-06  A61K 38/00 UNIV FLORIDA METHODS AND COMPOSITIONS FOR THE EARLY DETECTION AND TREATMENT OF INSULIN DEPENDENT DIABETES MELLITUS 
Buy PDF- 86pp WO9010449 1990-09  A61K 35/12 COHEN IRUN R DIAGNOSIS AND TREATMENT OF INSULIN DEPENDENT DIABETES MELLITUS 
Buy PDF- 78pp WO9206105 1992-04  A61K 38/00 TRIGEN INCORPORATED ANTIBODIES AND METHODS FOR DIAGNOSIS AND TREATMENT OF DIABETES 
Buy PDF- 52pp WO9214485 1992-09  A61K 37/56 AMRAD CORP LTD A METHOD FOR THE DIAGNOSIS AND TREATMENT OF GLUTAMIC ACID DECARBOXYLASE AUTOANTIGEN ASSOCIATED DISEASES 
Buy PDF- 46pp WO9220811 1992-11  A61K 38/00 THE BOARD OF REGENTS OF THE UNIVERSITY OF ... CLONING AND EXPRESSION OF HUMAN ISLET GLUTAMIC ACID DECARBOXYLASE AUTOANTIGEN 


Other Abstract Info: CHEMABS 117(23)227775Q CHEMABS 127(23)315578Q CHEMABS 118(23)225673B CHEMABS 123(03)028599J CHEMABS 127(23)315578Q DERABS C1992-150489 DERABS C1992-425701 DERABS C1995-131360 DERABS C2000-095930 DERABS C2000-500251

Other References:
  • Geysen et al., PNAS, vol. 81, pp. 3998-4002, 1984.
  • Bu et al., PNAS, vol. 89, pp. 2115-2119, Mar. 1992.
  • Revelation of Specificity of 64K Autoantibodies in IDDM Serums by High-Resolution 2-D Gel Electrophoresis Baekkeskov, et al., Diabetes, 38:1133-1141, 1989. (9 pages) Cited by 9 patents
  • Antigen Recognition in Autoimmune Encephalomyelitis and the Potential for Peptide-Mediated Immunotherapy Wraith, et al., Cell, 59:247-255, Oct. 20, 1989. (9 pages) Cited by 56 patents
  • Effect of Coxsackievirus B4 Infection in Mice on Expression of 64,000-M Autoantigen and Glucose Sensitivity of Islets Before Development of . . . Gerling, et al., Diabetes, 37:1419-1425, 1988. (7 pages) Cited by 6 patents
  • Molecular Mimicry and Diabetes Dyrberg, Current Topics in Microbiology & Immun., 145:118-125, 1989.
  • Rat Brain Glutamic Acid Decarboxylase Sequence Deduced from a Cloned cDNA Julien, et al., Journal of Neurochemistry, 54:703-705, 1990. (3 pages) Cited by 16 patents
  • Molecular Mimicry and Myasthenia Gravis Schwimmbeck, et al., J. Clin. Invest., 84:1174-1180, Oct. 1989. (7 pages) Cited by 7 patents
  • A molecular basis for genetic susceptibility to insulin-dependent diabetes mellitus Todd, et al., TIG, No.5, 4:129-134, May 1988. (6 pages) Cited by 7 patents
  • Characterization of the Proteins Purified with Monoclonal Antibodies to Glutamic Acid Decarboxylase Chang and Gottlieb, The Journal of Neuroscience, No.8, 6:2123-2130, Jun. 1988. (8 pages) Cited by 14 patents
  • Evidence for Two Distinct forms of Native Glutamic Acid Decarboxylase in Rat Brain Soluble Extract: An Immunoblotting Study Legay, et al., Journal of Neurochemistry, 48:1022-1026, 1987. (5 pages) Cited by 9 patents
  • Molecular cloning, expression and in situ hybridization of rat brain glutamic acid decarboxylase messenger RNA Julien, et al., Neuroscience Letters, 73:173-180, 1987. (8 pages) Cited by 9 patents
  • Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase Baekkeskov, et al., Nature, 347:151-156, Sep. 13, 1990. (6 pages) Cited by 44 patents
  • Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus Michelesen, et al., Proc. Natl. Acad. Sci. USA, 88:8754-8758, Oct. 1991. (5 pages) Cited by 13 patents [ISI abstract]
  • Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome Solimena, et al., N. Engl. J. Med., 322:1555-1560, 1990. (6 pages) Cited by 13 patents
  • Glutamic Acid Decarboxylase cDNA: Nucleotide Sequence Encoding and Enzymatically Active Fusion Protein Kobayashi, et al., The Journal of Neuroscience, No. 7, 9:2768-2772, Sep. 1987. (5 pages) Cited by 10 patents
  • What Causes Diabetes? Atkinson & Maclaren, Scientific American, pp. 62-71, Jul. 1990. Cited by 12 patents
  • Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins Baekkeskov, et al., Nature, 298:167-169, Jul. 1982. (3 pages) Cited by 32 patents
  • Antibodies to a 64,000 M.tau. Human Inslet Cell Antigen Precede the Clinical Onset of Insulin-dependent Diabetes Baekkeskov, et al., J. Clin. Invest., 79:926-934, Mar. 1987. (9 pages) Cited by 23 patents
  • Cellular and Subcellular Localization of an M.tau. 64,000 Protein Autoantigen in Insulin-dependent Diabetes Christie, et al., The Journal of Biological chemistry, No.1, 265:376-381, Jan. 5, 1990. (6 pages) Cited by 14 patents
  • 64,000 M.tau. autoantibodies as predictors of insulin-dependent diabetes Atkinson, et al., The Lancet, 335:1357-1360, 1990. (4 pages) Cited by 19 patents
  • Predicting Type I Diabetes Ziegler, et al., Diabetes Care, 13:762-775, 1990. (14 pages) Cited by 11 patents
  • Brain Glutamate Decarboxylase Cloned in .lambda.gt-11: Fusion Protein Produces .tau.-Aminobutyric Acid Kaufman, et al., Science, 232:1138-1140, May 30, 1986. (3 pages) Cited by 16 patents
  • Characterization of a cDNA coding for rat glutamic acid decarboxylase Wyborski, et al., Molecular Brain Research, 8:193-198, 1990. (6 pages) Cited by 10 patents
  • Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxykase from the Mouse Katarova, et al., European Journal of Neuroscience, No.3, 2:190-202, 1990. (13 pages) Cited by 10 patents
  • Expression of the Neurotransmitter-Synthesizing Enzyme Glutamic Acid Decarboxylase in Male Germ Cells Persson, et al., Molecular and Cellular Biology, No.9, 10:4701-4711, Sep. 1990. (11 pages) Cited by 10 patents
  • Autoimmunity to Two Forms of Glutamate Decarboxylase in Insulin-dependent Diabetes Mellitus Kaufman, et al., J. Clin. Invest., 89:283-292, Jan. 1992. (10 pages) Cited by 7 patents [ISI abstract]
  • Determinant spreading and the dynamics of the autoimmune T-cell repertoire Lehmann, et al., Immunology Today, No.5, 14:203-208, 1993. (6 pages) [ISI abstract]
  • Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes Atkinson, et al., The Lancet, 339:458-459, Feb. 22, 1992. (2 pages) Cited by 9 patents [ISI abstract]
  • Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes Harrison, et al., The Lancet, 341:1365-1369, May 29, 1993. (5 pages) Cited by 4 patents [ISI abstract]
  • Autoantibodies to Glutamic Acid Decarboxylase in a Patient with Stiff-Man Syndrome, Epilepsy, and Type I Diabetes Mellitus Solimena, et al., N. Engl. J. Med., 318:1012-1020, Apr. 21, 1988. (9 pages) Cited by 6 patents


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