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 Title: |
US5677135:
Method for increasing the resistance of neural cells to βamyloid peptide toxicity
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Bredesen, Dale E.; Palos Verdes Estates, CA
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| Assignee: |
University of California, Los Angeles, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1997-10-14
/ 1996-08-12
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| Application Number: |
US1996000695923
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| IPC Code: |
Advanced:
A61K 38/18;
C12N 5/06;
G01N 33/50;
G01N 33/68;
G01N 33/74;
Core:
more...
IPC-7:
G01N 33/567;
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| ECLA Code: |
A61K38/18F; C12N5/06B8A; G01N33/50D2D; G01N33/68V2; G01N33/74; M12N501/130; M12N503/02; M12N510/00; S01N333/47A3; S01N333/71; S01N800/28B1;
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| U.S. Class: |
Current:
435/006;
435/007.1;
435/007.2;
435/007.21;
435/029;
435/032;
Original:
435/007.21;
435/007.1;
435/007.2;
435/240.1;
435/240.2;
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| Field of Search: |
435/004,7.1,7.2,7.21,240.1,240.2
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| Priority Number: |
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| Abstract: |
Neural cells which express P75 nerve growth factor receptor (p75NTR) and which have a low resistance to beta -amyloid peptide toxicity are treated with a binding agent that binds with p75NTR. The resulting neural cells display an increased resistance to beta -amyloid peptide toxicity. Mutant and transfected neural cells are also disclosed in which the ability to express p75NTR has been removed with a resultant increase in resistance to beta -amyloid peptide toxicity.
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| Attorney, Agent or Firm: |
Gray Cary Ware & Freidenrich ;
Reiter, Stephen E. ;
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| Primary / Asst. Examiners: |
Adams, Donald E.; Gucker, Stephen
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
This application is a divisional application of U.S. Ser. No. 08/328,581, filed Oct. 24, 1994, now issued as U.S. Pat. No. 5,576,209, the entire contents of which are hereby incorporated by reference herein.
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| Designated Country: |
AM AP AT BB BG BR BY CA CH CN CZ DE DK EP ES FI GB GE HU IS JP KE KG KP KR KZ LK LU LV MD MG MN MW NO NZ OA PL PT RO
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| Family: |
Show 4 known family members
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First Claim:
Show all 6 claims |
What is claimed is:
1. A method for increasing the resistance of neural cells to β-amyloid peptide toxicity wherein said neural cells naturally express the p75NTR, said method comprising:
- mutating said neural cells in a neural cell culture in vitro to form a mutant neural cell culture, wherein said neural cell culture comprises a plurality of neural cells which naturally express the p75NTR and which have a low resistance to β-amyloid peptide toxicity, and wherein the mutant neural cells in said mutant neural cell culture do not express the p75NTR ;
- and exposing said mutant neural cell culture to β-amyloid peptide wherein the resistance of said mutant neural cell culture to β-amyloid peptide toxicity is higher than the resistance of said neural cell culture to β-amyloid peptide toxicity.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
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