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 Title: |
US5679783:
DNA encoding a tissue differentiation affecting factor
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
De Robertis, Edward M.; Pacific Palisades, CA
Sasai, Yoshiki; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1997-10-21
/ 1994-11-22
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| Application Number: |
US1994000343760
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| IPC Code: |
Advanced:
C07K 14/475;
C12N 15/12;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
C07K 14/46;
C12N 15/12;
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| ECLA Code: |
C07K14/475;
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| U.S. Class: |
Current:
536/023.5;
435/069.1;
435/252.3;
435/320.1;
530/350;
Original:
536/023.5;
435/069.1;
435/172.3;
435/252.3;
435/320.1;
935/011;
935/022;
935/066;
530/350;
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| Field of Search: |
536/23.1,23.5
435/69.1,172.3,252.3,320.1
514/044
935/011,22,27,29,31,32,66
530/350
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| Government Interest: |
This invention was made with Government support under grant contract number HD-21502, awarded by the National Institutes of Health. The Government has certain rights in this invention.
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| Priority Number: |
| 1994-11-22 |
US1994000343760 |
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| Abstract: |
A functional polypeptide designated "chordin" is described that is capable of inducing dorsal (and neural tissue) development in vertebrates, and which appears to be a secreted protein. There are substantial regions of conservation with Xenopus chordin with mouse chordin, and the human gene should also be similar in those regions. A full length Xenopus cDNA for chordin is illustrated by FIGS. 1A-1F, and contains a reading frame encoding a 941 residue, 105 kDa precursor protein.
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| Attorney, Agent or Firm: |
Majestic, Parsons, Siebert & Hsue ;
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| Primary / Asst. Examiners: |
Ulm, John; Mertz, Prema
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Family: |
Show 5 known family members
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First Claim:
Show all 8 claims |
It is claimed:
1. An isolated DNA encoding a functional protein, and having the nucleotide sequence of SEQ ID NO:1.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 9 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 127(25)342655U
CHEMABS 127(25)342655U
CHEMABS 130(06)062035B
DERABS C1997-525754
DERABS C1997-525754
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| Other References: |
Sasai et al (1994) Cell, vol. 79, pp. 779-790.
(12 pages)
Cited by 19 patents
[ISI abstract]
Hawley (1981) The Condensed chemical dictionary, Van Nostrand Reinhold Company, 10th edition, p. 759.
Wahl, Stern and Stark, "Efficient Transfer of Large DNA Fragments from Agarose Gels to Diazobenzyloxymethyl-paper and Rapid Hybridization by Using Dextran Sulfate", Proc. Natl. Acad. Sci. USA, vol. 76, No. 8, pp. 3683-3687, Aug. 1979.
(5 pages)
Cited by 25 patents
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(5 pages)
Cited by 118 patents
Hunt and Barker, "Von Willebrand Factor Shares a Distinctive Cysteine-Rich Domain with Thrombospondin and Procollagen", Biochemical and Biophysical Research Communications, vol. 144, No. 2, pp. 876-882, Apr. 29, 1987.
(7 pages)
Kao and Elinson, "The Entire Mesodermal Mantle Behaves as Spemann's Organizer in Dorsoanterior Enhanced Xenopus Laevis Embryos", Developmental Biology, vol. 127, pp. 64-77, 1988.
(14 pages)
Cited by 4 patents
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(5 pages)
Cited by 6 patents
Sokol, Wong and Melton, "A Mouse Macrophage Factor Induces Head Structures and Organizes a Body Axis in Xenopus", Science, vol. 249, pp. 561-564, Aug. 3, 1990.
(4 pages)
Cited by 23 patents
Blumberg, Wright, De Robertis and Cho, "Organizer-Specific Homeobox Genes in Xenopus Laevis Embryos", Science, vol. 253, pp. 194-196, Jul. 12, 1991.
(3 pages)
Cited by 4 patents
[ISI abstract]
Amaya, Musci and Kirschner, "Expression of a Dominant Negative Mutant of the FGF Receptor Disrupts Mesoderm Formation in Xenopus Embryos", Cell, vol. 66, pp. 257-270, Jul. 26, 1991.
(14 pages)
Cited by 9 patents
[ISI abstract]
Smith and Harland, "Injected Xwnt-8 RNA Acts Early in Xenopus Embryos to Promote Formation of a Vegetal Dorsalizing Center", Cell, vol. 67, pp. 753-765, Nov. 15, 1991.
(13 pages)
Cited by 15 patents
[ISI abstract]
Ferguson and Anderson, "Localized Enhancement and Repression of the Activity of the TGF-β Family Member, Decapentaplegic, is Necessary for Dorsal-Ventral Pattern Formation in the Drosophila Embryo", Development, vol. 114, pp. 583-597, 1992.
(15 pages)
Cited by 2 patents
[ISI abstract]
Schonbaum, Organ, Qu and Cavener, "The Drosophila Melanogaster Stranded at Second (sas) Gene Encodes a Putative Epidermal Cell Surface Receptor Required for Larval Development", Developmental Biology, vol. 151, pp. 431-445 (1992).
(15 pages)
[ISI abstract]
Jones, Lyons, Lapan, Wright and Hogan, "DVR-4 (Bone Morphogenetic Protein-4) as a Posterior-Ventralizing Factor in Xenopus Mesoderm Induction", Development, vol. 115, pp. 639-647, 1992.
(9 pages)
Cited by 5 patents
[ISI abstract]
Smith and Harland, "Expression Cloning of Noggin a New Dorsalizing Factor Localized to the Spemann Organizer in Xenopus Embryos", Cell, vol. 70, pp. 829-840, Sep. 4, 1992.
(12 pages)
Cited by 12 patents
[ISI abstract]
Fainsod, Steinbeisser and De Robertis, "On the Function of BMP-4 in Patterning the Marginal Zone of the Xenopus Embryo", The EMBO Journal, vol. 13, No. 21, pp. 5015-5025, 1994.
(11 pages)
Cited by 4 patents
[ISI abstract]
Fran.cedilla.ois, Solloway, O'Neill, Emery and Bier, "Dorsal-Ventral Patterning of the Drosophila Embryo Depends on a Putative Negative Growth Factor Encoded by the Short Gastrulation Gene", Genes & Development, vol. 8, pp. 2602-2616, 1994.
(15 pages)
Cited by 2 patents
[ISI abstract]
Hemmati-Brivanlou, Kelly and Melton, "Follistatin, an Antagonist of Activin, is Expressed in the Spemann Organizer and Displays Direct Neuralizing Activity", Cell, vol. 77, pp. 283-295, Apr. 22, 1994.
(13 pages)
Cited by 14 patents
[ISI abstract]
Graff, Thies, Song, Celeste and Melton, "Studies with a Xenopus BMP Receptor Suggest that Ventral Mesoderm-Inducing Signals Override Dorsal Signals in Vivo", Cell, vol. 79, pp. 169-179, Oct. 7, 1994.
(11 pages)
Cited by 8 patents
[ISI abstract]
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