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 Title: |
US5688936:
Vesicle membrane transport proteins
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Edwards, Robert H.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1997-11-18
/ 1993-05-14
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| Application Number: |
US1993000063552
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| IPC Code: |
Advanced:
C07K 14/47;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
C07H 21/04;
C07K 14/435;
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| ECLA Code: |
C07K14/47;
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| U.S. Class: |
Current:
536/023.5;
530/350;
530/827;
Original:
536/023.5;
530/350;
530/827;
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| Field of Search: |
536/23.1,23.5
435/320.1,240.2,240.4,252.3,254.11,254.2
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| Government Interest: |
GOVERNMENT RIGHTS
This invention was made with governmental support under National Science Foundation (NSF) grant number BNS 90-11993. The government has certain rights in the invention.
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| Priority Number: |
| 1993-05-14 |
US1993000063552 |
| 1992-07-30 |
US1992000923096 |
| 1992-06-11 |
US1992000899074 |
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| Abstract: |
Complete cDNA and amino acid sequences are disclosed for rat adrenal-specific and brain-specific transport protein, as well as for human brain-specific transport protein. Methods for obtaining the genes encoding these proteins and for obtaining recombinantly produced protein are described. Antibodies and methods for isolating additional vesicle membrane transport proteins are also described. Methods for using the vesicle membrane transport proteins to identify compounds that selectively inhibit transport of toxic molecules into vesicles, and that prevent inhibition of transport of toxic molecules are also provided. The invention includes methods to treat and diagnose diseases associated with sequestration of toxic molecules in mammalian cells.
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| Attorney, Agent or Firm: |
Merchant, Gould, Smith, Edell, Welter & Schmidt ;
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| Primary / Asst. Examiners: |
Zitomer, Stephanie W.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
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| Related Applications: |
| Application Number |
Filed |
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Pub. Date |
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| US1992000923096 | 1992-07-30 |
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| US1992000899074 | 1992-06-11 |
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| Parent Case: |
CROSS-REFERENCES
This application is a continuation-in-part of U.S. application Ser. No. 07/923,096 by Robert H. Edwards, filed Jul. 30, 1992, and entitled "Vesicle Membrane Transport Proteins", now abandoned, which in turn is a continuation-in-part of U.S. application Ser. No. 07/899,074 by Robert H. Edwards, filed Jun. 11, 1992 and also entitled "Vesicle Membrane Transport Proteins", now abandoned. Both of these applications are incorporated herein by this reference.
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| Designated Country: |
AU CA EP JP
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| Family: |
Show 3 known family members
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| Claim |
I claim:
1. An isolated DNA molecule encoding the amino acid sequence shown in FIG. 1 (SEQ ID NO: 2).
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
Show description
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| Forward References: |
Show 5 U.S. patent(s) that reference this one
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| Other Abstract Info: |
CHEMABS 120(21)264218T
CAN128(04)031108G
CHEMABS 128(04)031108G
DERC98-008039
DERABS C94-007556
DERABS C98-008039
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[ISI abstract]
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