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 Title: |
US5691135:
Immunoglobulin superantigen binding to gp 120 from HIV
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Braun, Jonathan; Sherman Oaks, CA
Goodglick, Lee A.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1997-11-25
/ 1994-09-14
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| Application Number: |
US1994000306116
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| IPC Code: |
Advanced:
G01N 33/569;
Core:
more...
IPC-7:
C12Q 1/70;
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| ECLA Code: |
G01N33/569K2;
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| U.S. Class: |
Current:
435/005;
435/007.1;
435/007.2;
435/007.24;
435/007.92;
435/974;
Original:
435/005;
435/007.1;
435/007.2;
435/007.24;
435/007.92;
435/974;
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| Field of Search: |
435/005,7.1,7.2,7.24,7.92,974
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| Government Interest: |
GOVERNMENT INTEREST IN THE INVENTION
Certain aspects of the invention disclosed herein were made with United States government support under grant number CA 12800 from the National Institutes of Health. Accordingly, the United States Government has certain rights in the invention.
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| Priority Number: |
| 1994-09-14 |
US1994000306116 |
| 1994-06-14 |
US1994000259669 |
| 1993-01-26 |
US1993000009705 |
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| Abstract: |
VH3 and VH4 type immunoglobulins display superantigen-type binding affinity for the HIV gp120 envelope glycoprotein. VH3 and VH4 type antibody molecules, including IgG and IgM, are shown to suppress HIV infection in vivo and in vitro. Determining the level of such antibody molecules is correlated to the advancement of HIV disease state.
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| Attorney, Agent or Firm: |
Knobbe Martens Olson & Bear, LLP ;
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| Primary / Asst. Examiners: |
Nucker, Christine M.; Stucker, Jeffrey
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| INPADOC Legal Status: |
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| Related Applications: |
| Application Number |
Filed |
Patent |
Pub. Date |
Title |
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| US1994000259669 | 1994-06-14 |
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| US1993000009705 | 1993-01-26 |
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| Parent Case: |
RELATED APPLICATIONS
This application is a continuation-in-part of U.S. application Ser. No. 08/259,669, filed Jun. 14, 1994, now abandoned, which is a continuation of U.S. application Ser. No. 08/009,705, filed Jan. 26, 1993 now abandoned. The disclosures of these related applications are hereby incorporated herein by this reference thereto.
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| Family: |
None
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First Claim:
Show all 3 claims |
What is claimed is:
1. A method of determining the HIV-1 disease state of a patient infected with HIV-1, comprising:
- obtaining a biological sample from said patient, said sample containing antibodies;
- determining the level of VH3-containing antibodies having gp120 binding activity in said sample; and
- comparing the determined level of said antibodies with a predetermined level of said antibodies in a biological sample from an asymptomatic HIV-1 infected patient, wherein a lower level in said biological sample from said patient relative to said predetermined level is indicative of a disease state more advanced than said asymptomatic HIV-1 infected patient.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
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