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 Title: |
US5691151:
Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Braun, Jonathan; Encino, CA
Targan, Stephan R.; Los Angeles, CA
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| Assignee: |
Regents of University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1997-11-25
/ 1994-10-07
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| Application Number: |
US1994000320515
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| IPC Code: |
Advanced:
C07K 16/42;
G01N 33/569;
G01N 33/68;
Core:
more...
IPC-7:
G01N 33/564;
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| ECLA Code: |
C07K16/42K14B; G01N33/569D4; G01N33/569H2; G01N33/68B4;
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| U.S. Class: |
Current:
435/007.2;
435/007.24;
435/007.25;
435/007.32;
435/007.9;
435/007.95;
435/961;
435/965;
435/975;
436/506;
436/508;
Original:
435/007.2;
435/007.24;
435/007.25;
435/007.32;
435/007.9;
435/007.95;
435/961;
435/965;
435/975;
436/506;
436/508;
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| Field of Search: |
435/7.2,7.24,7.25,7.32,7.9,7.95,961,965,975
436/506,508
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| Government Interest: |
I. ACKNOWLEDGEMENT
This invention was made with support under grant numbers DK46763 and CA12800 from the National Institute of Health. Accordingly, the United States Government has certain rights in the invention.
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| Priority Number: |
| 1994-10-07 |
US1994000320515 |
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| Abstract: |
The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The present invention also provides kits for screening ulcerative colitis and Crohn's disease.
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| Attorney, Agent or Firm: |
Campbell & Flores LLP ;
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| Primary / Asst. Examiners: |
Saunders, David;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
CA EP JP
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| Family: |
Show 4 known family members
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First Claim:
Show all 66 claims |
We claim:
1. A method of screening a patient for Crohn's disease ("CD") and ulcerative colitis ("UC"), comprising:
- (a) determining the amount of VH3-15 autoantibody in a sample from the patient,
- (b) detecting the presence or absence of pANCA in a sample from the same patient,
- wherein an amount of VH3-15 autoantibody in the sample which exceeds the amount of VH3-15 autoantibody in a VH3-15 assay control and the absence of pANCA indicates CD, and
- wherein an amount of VH3-15 autoantibody in the sample that does not exceed the amount of VH3-15 autoantibody in a VH3-15 assay control and the presence of pANCA indicates UC.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 8 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 125(03)031911B
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| Other References: |
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