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 Title: |
US5693486:
DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Lehrer, Robert I.; Santa Monica, CA
Kokryakov, Vladimir N.; Los Angeles, CA
Harwig, Sylvia S. L.; Woodland Hills, CA
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| Assignee: |
IntraBiotics, Sunnyvale, CA
other patents from INTRABIOTICS (735637) (approx. 1)
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| Published / Filed: |
1997-12-02
/ 1994-01-13
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| Application Number: |
US1994000182483
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| IPC Code: |
Advanced:
A01N 63/02;
C07K 7/08;
C07K 16/18;
C12N 15/12;
A61K 38/00;
Core:
C07K 7/00;
more...
IPC-7:
C07K 7/00;
C07K 7/08;
C12N 15/12;
C12N 15/70;
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| ECLA Code: |
A01N63/02; C07K7/08A; C07K16/18;
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| U.S. Class: |
Current:
435/069.1;
435/252.3;
435/320.1;
530/321;
530/323;
530/326;
536/023.5;
Original:
435/069.1;
435/252.3;
435/320.1;
530/321;
530/323;
530/326;
536/023.5;
935/011;
935/029;
935/060;
935/073;
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| Field of Search: |
530/321,323,326
536/23.5
435/69.1,252.3,320.1
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| Government Interest: |
This invention was made with funding from NIH Grant No. A122839. The U.S. Government has certain rights in this invention.
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| Priority Number: |
| 1994-01-13 |
US1994000182483 |
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| Abstract: |
Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced, are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula:
A1 -A2 -A3 -A4 -A5 -C-A7 -C-A9 -A10 -A11 -A12 -C-A14 -C-A16 -(A17 -A18)(1)(SEQ ID NO:1)
and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, either in optionally --SH stabilized linear or in cystine-bridged form
- wherein A1, A9, A10, and A11 are basic amino acids;
- A2 and A3 are small amino acids;
- A5, A7, A12, A14 and A16 are hydrophobic amino acids; and
- A4 is a basic or a small amino acid;
- A17 is not present or, if present, is a small amino acid;
- A18 is not present or, if present, is a basic amino acid, and
- modified form of formula (1) SEQ ID NO:1) wherein each of 1-4 cysteines is independently replaced by a hydrophobic amino acid or a small amino acid.
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| Attorney, Agent or Firm: |
Morrison & Foerster LLP ;
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| Primary / Asst. Examiners: |
Wax, Robert A.; Moore, William W.
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This is a Continuation-In-Part of U.S. Ser. No. 08/095,769 filed 26 Jul. 1993 issued as U.S. Pat. No. 5,464,823, on Nov. 7, 1995 which is a Continuation-In-Part of U.S. Ser. No. 08/093,926 filed 20 Jul. 1993, now abandoned. The contents of these applications are incorporated herein by reference.
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| Designated Country: |
BB BG BR BY CA CN CZ FI HU KP KR KZ LK LV MG MN MW NO NZ OA PL BE CH FR GB GR IE IT LI LU MC NL
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| Family: |
Show 35 known family members
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First Claim:
Show all 17 claims |
We claim:
1. A purified and isolated DNA which encodes the amino acid sequence
A1 -A2 -A3 -A4 -A5 -C-A7 -C-A9 -A10 -A11 -A12 -C-A14 -C-A16 -(A17 -A18)(1)(SEQ ID NO:1)
- wherein A1, A9, A10 and A11 are basic amino acids;
- A2 and A3 are small amino acids;
- A5, A7, A12, A14 and A16 are hydrophobic amino acids; and
- A4 is a basic or a small amino acid;
- A17 is not present or, if present, is a small amino acid;
- A18 is not present or, if present, is a basic amino acid wherein a peptide comprising said amino acid sequence has antimicrobial activity against E. coli, L. monocytogenes, or Candida albicans.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 13 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 122(19)230760Q
CHEMABS 128(05)045808X
CHEMABS 124(09)106630Z
CHEMABS 128(05)045808X
CHEMABS 128(11)127091X
CHEMABS 129(18)225713S
CHEMABS 132(01)002807M
DERABS C1995-075188
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| Other References: |
Matsumoto, S., et al., Chemical and Pharmaceutical Bulletin, vol. 40, No. 10, pp. 2701-2706, 1992.
(6 pages)
[ISI abstract]
Tamamura, H. et al., "A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22 ([Tyr5,12, Lys7 ]-polyphemusin II), determined by nuclear magnetic resonance," Biochimica et Biophysica Acta (1993) 1163:209-216.
(8 pages)
Cited by 12 patents
[ISI abstract]
Tamamura, H. et al. "Antimicrobial Activity and Conformation of Tachyplesin I and Its Analogs," Chem Pharm Bull (1993) 41(5):978-980.
(3 pages)
Cited by 12 patents
[ISI abstract]
Zhao, C. et al., "Identification of a new member of the protegrin family by cDNA cloning," FEBS Letters (1994) 346:285-288.
(4 pages)
Cited by 9 patents
[ISI abstract]
Lehrer et al., Direct Inactivation of Viruses by MCP-1 an MCP-2 Natural Peptide Antibiotics from Rabbit Leukocytes; J. Virol. (1985) 54:467-472.
(6 pages)
Cited by 15 patents
Mirgorodskaya, et al., Primary structure of three cationic peptides from porcine neutrophils; FEBS (1993) 330:339-342.
(4 pages)
Cited by 14 patents
[ISI abstract]
Storici, et al., A Novel cDNA Sequence Encoding a Pig Leukocyte Antimicrobial Peptide with a Cathelin-like Pro-sequence; Biochem. Biophys. Res. Comm. (1993) 196:1363-1367.
(6 pages)
Cited by 14 patents
[ISI abstract]
Rustici et al., Molecular Mapping and Detoxification of the Lipid A Binding Site by Synthetic Peptides; Science (1993) 259:361-364.
(5 pages)
Cited by 19 patents
[ISI abstract]
Matsuzaki et al., Role of Disulfide Linkages in Tachytoplesin--Lipid Interactions; Biochemistry (1993) 32:11704-11710.
(7 pages)
Cited by 10 patents
[ISI abstract]
Hoess et al., EMBO J. (1993) 12:3351-3356.
(6 pages)
Cited by 20 patents
[ISI abstract]
Elsbach et al., Current Opinion in Immunology (1993) 5:103-107.
(5 pages)
Cited by 14 patents
[ISI abstract]
Kokryakov et al.; Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins; FEBS 327(2):231-236 (1993).
(6 pages)
Cited by 19 patents
[ISI abstract]
Selsted et al.; Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils; J. Biol. Chem. 260(8):4579-4584 (1985).
(6 pages)
Cited by 25 patents
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| Continuity Data: |
| Application Number | Filed | Notes |
|---|
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US2003000627829 | 2003-07-24 | is a
continuation of |
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US2000000539443
| 2000-03-30 |
(abandoned)
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US2000000539443 | 2000-03-30 | is a
continuation of |
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US1998000128345
| 1998-08-03 |
(granted)
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US6159936 issued 2000-12-12 Compositions and methods for treating and preventing microbial and viral infections
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US1998000128345 | 1998-08-03 | is a
division of |
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US1995000499523
| 1995-07-07 |
(granted)
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US1998000128345 | 1998-08-03 | is a
continuation of |
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US1995000499523
| 1995-07-07 |
(granted)
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US1998000128345 | 1998-08-03 | is a
division of |
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US1995000451832
| 1995-05-26 |
(abandoned)
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US1995000499523 | 1995-07-07 | is a
continuation in part of |
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US1995000451832
| 1995-05-26 |
(abandoned)
|
|
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US1998000128345 | 1998-08-03 | is a
division of |
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US1994000243879
| 1994-05-17 |
(granted)
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US5708145 issued 1998-01-13 Immunglobulins reactive with protegrins
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US1995000451832 | 1995-05-26 | is a
continuation in part of |
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US1994000243879
| 1994-05-17 |
(granted)
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US5708145 issued 1998-01-13 Immunglobulins reactive with protegrins
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US1998000128345 | 1998-08-03 | is a
division of |
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>US1994000182483<
| 1994-01-13 |
(granted)
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| |
US5693486 issued 1997-12-02 DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
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|
|
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US1994000243879 | 1994-05-17 | is a
continuation in part of |
|
>US1994000182483<
| 1994-01-13 |
(granted)
|
| |
US5693486 issued 1997-12-02 DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
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|
|
|
US1998000128345 | 1998-08-03 | is a
division of |
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US1993000095769
| 1993-07-26 |
(granted)
|
| |
US5464823 issued 1995-11-07 Mammalian antibiotic peptides
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>US1994000182483< | 1994-01-13 | is a
continuation in part of |
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US1993000095769
| 1993-07-26 |
(granted)
|
| |
US5464823 issued 1995-11-07 Mammalian antibiotic peptides
|
|
|
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US1998000128345 | 1998-08-03 | is a
division of |
|
US1993000093926
| 1993-07-20 |
(abandoned)
|
|
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US1993000095769 | 1993-07-26 | is a
continuation in part of |
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US1993000093926
| 1993-07-20 |
(abandoned)
|
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