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 Title: |
US5694938:
Methodology and apparatus for diffuse photon mimaging
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Feng, Shechao C.; Los Angeles, CA
Zeng, Fanan; Los Angeles, CA
Zhao, Hui-Lin; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1997-12-09
/ 1995-06-07
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| Application Number: |
US1995000483329
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| IPC Code: |
Advanced:
A61B 5/00;
G01N 21/47;
Core:
more...
IPC-7:
A61B 8/00;
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| ECLA Code: |
A61B5/00P6; G01N21/47S;
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| U.S. Class: |
Current:
600/425;
600/473;
600/475;
Original:
128/664;
128/665;
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| Field of Search: |
128/664,665,653.1
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| Government Interest: |
This invention was made in part with the assistance of government funding under the Office of Naval Research (ONR) Grant No. N00014-92-J-4004 from the Department of Defense, the Office of Basic Energy Research Grant No. DE-FG03-88ER45378 from the Department of Energy. The government may have rights to the invention.
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| Priority Number: |
| 1995-06-07 |
US1995000483329 |
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| Abstract: |
Non-invasive near infrared optical medical imaging devices for both hematoma detection in the brain and early tumor detection in the breast is achieved using image reconstruction which allows a mapping of the position dependent contrast diffusive propagation constants, which are related to the optical absorption coefficient and scattering coefficient in the tissue, at near infrared wavelengths. Spatial resolutions in the range of 5 mm for adult brain sizes and breast sizes can be achieved. The image reconstruction utilizes WKB approximation on most probable diffusion paths which has as lowest order approximation the straight line-of-sight between the plurality of sources and the plurality of detectors. The WKB approximation yields a set of linear equations in which the contrast optical absorption coefficients are the unknowns and for which signals can be generated to produce a pixel map of the contrast optical resolution of the scanned tissue.
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| Attorney, Agent or Firm: |
Dawes, Daniel L. ;
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| Primary / Asst. Examiners: |
Lateef, Marvin M.; Fields, Derrick
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
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| Family: |
None
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First Claim:
Show all 24 claims |
We claim:
1. A method for optical tomography of a target having a shape and dimension disposed in space comprising:
- exposing a target with an amplitude modulated optical signal generated by a source at a source position next to said target;
- detecting said amplitude modulated optical signal from said source at a detection position next to said target, said source and detection positions defining a line of most probable diffusion path being defined between said source and detection positions;
- repeatedly exposing said target and detecting said amplitude modulated optical signal to define to a pluraltity of said lines of most probable diffusion paths;
- storing a pixel lattice in a computer memory corresponding to said space in which said target is located, said pixel lattice corresponding to a plurality of pixel cells, said line of most probable diffusion path between said source and detection positions being disposed across said plurality of pixel cells to select a subplurality of said pixel cells of said lattice;
- storing a plurality of reference signals JO in said computer memory corresponding to an expected amplitude modulated optical signal for each pair of source and detection positions in a reference homogeneous medium with the same said dimension and shape as said target of which the absorption and scattering coefficients are constant and are chosen to be at least approximately equal to the average values of absorption and scattering coefficients respectively of said target; and
- generating a plurality of contrast diffusive propagation constant signals, δ.kappa.(xi), each contrast diffusive propagation constant being assigned to one of said subplurality of said pixel cells in which said line of most probable diffusion path between said source and detection positions is disposed, said contrast diffusive propagation constant signal being equal in magnitude to a difference in diffusive propagation constant signals of said target at a spatial position corresponding to each of said selected pixel cells within said pixel lattice, said difference being the difference between said diffusive propagation constant signal of said target to be imaged and said diffusive propagation constant signal of said reference homogeneous medium, wherein said contrast diffusive propagation constant signals are related to the computed photon flux JO at said detection position for the said reference homogeneous medium and measured photon flux JM at said detection position for the said target to be imaged by [Figure] where δ.kappa.(xi)=.kappa.(xi)-.kappa.0 is the contrast diffusive propagation constant of said target at angular modulating frequency ω of said amplitude modulation of said optical signal, li is the length segment of said most probable diffusion path, and .kappa.0 is the diffusive propagation constant of the said reference homogeneous medium, where the sum is taken on said line of most probable diffusion path which has as its lowest order approximation a straight line-of-sight extending between said source position and said detection position, and where i is an index for each pixel on said line of most probable diffusion path;
- storing said plurality of contrast diffusion propagation constant signals in said pixel lattice in said computer memory,
- whereby an optical tomograph of said target represented in said lattice may be provided.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 15 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
DERABS G1998-040876
DERABS G1998-040876
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| Other References: |
M.A. O'Leary et al., "Images of Inhomogeneous Turbid Media Using Diffuse Photo Density Waves," OSA Proc on Advances in Optical Imaging & Photon Migration, vol. 21 (1994).
R.R. Alfano et al., "Time-Resolved Imaging of Translucent Droplets in Highly Scattering Turbid Media," Science, vol. 264:1913-15 (1994).
(3 pages)
Cited by 5 patents
[ISI abstract]
S.R. Arrige, "Iterative Reconstruction of Near Infrared Absorption Images," Inverse Probelsm in Scattering and Imaging, SPEI, vol 1767:372(1992).
H.L. Graber et al., "Near Infrared Absorption Imaging of Dense Scattering Media by Steady State Diffusion Tomography," Photon Migration in Imaging in Random Media and Tissues, SPIE, vol. 1888:372 (1993).
J.C. Schotland et al., "Photon Hitting Density" Applied Optics, vol 32, No. 4:448-53 (1993).
(6 pages)
Cited by 6 patents
[ISI abstract]
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