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Title: US5698198: Method for treating gram negative bacterial infections in humans
[ Derwent Title ]

Country: US United States of America

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Inventor: Young, Lowell S.; San Francisco, CA

Assignee: The Regents of the University of California, Berkeley, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1997-12-16 / 1995-06-06

Application Number: US1995000466327
IPC Code: Advanced: C07K 16/12; A61K 38/00;
Core: more...
IPC-7: A61K 39/40; A61K 48/00; C07K 16/12; C12N 15/12;

ECLA Code: C07K16/12A; C07K16/12A14;

U.S. Class: Current: 424/150.1; 424/164.1; 435/340; 530/388.4;
Original: 424/150.1; 424/164.1; 530/388.4; 435/340;

Field of Search: 424/150.1,164.1,169.1,170.1 530/388.4,809 435/340

Priority Number:
1995-06-06  US1995000466327
1994-07-01  US1994000277934
1993-11-18  US1993000154142
1991-11-20  US1991000798031
1989-02-03  US1989000306712
1986-04-24  US1986000855878

Abstract: The present invention provides novel hybridoma cell lines which produce monoclonal antibodies (MoAbs) that bind epitopes found on lipopolysaccharide most commonly associated with the endotoxin core of gram negative bacteria and exhibit broad cross-reactivity with gram negative bacteria of different genera and effectively neutralize endotoxin. At least one of the MoAbs disclosed (XMMEN-J5D) binds an epitope also found on gram positive bacteria. The hybridomas are produced by fusing an immortal cell, a cell having the ability to replicate indefinitely in myeloma cell culture, and an effector immune cell following immunization of the immune cell host with a preparation of a gram negative bacteria. While several individual hybridoma cell lines producing monoclonal antibodies to lipopolysaccharide are described, the present invention adds to the state of the art an entire family of hybridomas producing monoclonal antibodies to lipopolysaccharide-associated epitopes. The monoclonal antibodies produced by the hybridoma cell lines of the present invention are useful in the detection of bacterial infections, therapy and prophylaxis of bacterial endotoxemia and infection caused by gram negative bacteria.

Attorney, Agent or Firm: Townsend and Townsend and Crew LLP ;

Primary / Asst. Examiners: Loring, Susan A.;

Maintenance Status: E1 Expired  Check current status

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Related Applications:
Application Number Filed Patent Pub. Date  Title
US1994000277934 1994-07-01    1996-01-16  Method for treating gram negative bacterial infections in humans
US1993000154142 1993-11-18       
US1991000798031 1991-11-19       
US1989000306712 1989-02-03       
US1986000855878 1986-04-24    1990-04-17  Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US1995000781242 1995-09-27    1988-10-11  Monoclonal antibody reactive with Pseudomonas Aeruginosa


       
Parent Case:

CROSS-REFERENCE TO RELATED APPLICATIONS
    This application is a continuation of U.S. application Ser. No. 08/277,934, filed Jul. 1, 1994, now U.S. Pat. No. 5,484,591 which is a continuation of U.S. application Ser. No. 08/154,142, filed Nov. 18, 1993, now abandoned, which was a continuation of U.S. application Ser. No. 07/798,031, filed Nov. 20, 1991, now abandoned, which was a continuation of U.S. application Ser. No. 07/306,712, filed Feb. 3, 1989, now abandoned, which was a continuation of U.S. Ser. No. 06/855,878, filed Apr. 24, 1986 which issued as U.S. Pat. No. 4,918,163 and which was a continuation-in-part application of Ser. No. 06/781,242, filed Sep. 27, 1985 which issued as U.S. Pat. No. 4,777,136, the disclosures of which are hereby incorporated by reference.

Designated Country: BE CH FR GB IT LI LU NL SE 

Family: Show 37 known family members
First Claim:
Show all 2 claims		 What is claimed is:     1. A method for therapeutically treating a human having a gram negative bacterial infection, comprising administering to the human a therapeutically effective amount of an anti-lipid A region monoclonal antibody of the IgM isotype which competitively inhibits the binding of the monoclonal antibody produced by the hybridoma cell line ATCC Accession No. HB9081 to purified lipopolysaccharide from the J5 mutant of E. coli as measured by an enzyme immunoassay or other competitive inhibition immunoassay wherein the monoclonal antibody is administered in conjunction with antibiotic therapy.

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Forward References: Show 3 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (3)   |   Backward references (13)   |   Citation Link

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PDF		 Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 7pp US4428931  1984-01 Tolman et al.  Merck & Co., Inc. Bacterial toxoids and gram-negative immune globulin therefrom
Buy PDF- 10pp US4443549  1984-04 Sadowski  Molecular Genetics, Inc. Production of monoclonal antibodies against bacterial adhesins
Buy PDF- 6pp US4464465  1984-08 Lostrom  Genetic Systems Corporation Cell-driven viral transfer in eukaryotes
Buy PDF- 10pp US4525453  1985-06 Guardino et al.  Eastman Kodak Company Process for rapidly differentiating between gram-negative and gram-positive microorganisms
Buy PDF- 6pp US4574116  1986-03 Kaplan et al.  The Board of Trustees of the Leland Stanford Jr. University Methods and cell lines for immortalization and monoclonal antibody production by antigen-stimulated B-lymphocytes
Buy PDF- 4pp US4587121  1986-05 Collins et al.  Miles Laboratories, Inc. High titer Pseudomonas immune serum globulin
Buy PDF- 5pp US4617264  1986-10 Whiteley et al.  Syntex (U.S.A.) Inc. Pretreatment method and composition
Buy PDF- 17pp US4647447  1987-03 Gries et al.  Schering Aktiengesellschaft Diagnostic media
Buy PDF- 11pp US4652518  1987-03 Makela et al.  Orion Corporation, Ltd. Diagnosing chlamydia infections with Re-lipopolysaccharide complexed to carrier or antibody thereto
Buy PDF- 9pp US4683196  1987-07 McLaughlin  Meru, Inc. Method and materials for the identification of lipopolysaccharide producing microorganisms
Buy PDF- 13pp US4689299  1987-08 Insel et al.  University of Rochester Human monoclonal antibodies against bacterial toxins
Buy PDF- 17pp US5057598  1991-10 Pollack et al.  Centocor, Inc. Monoclonal antibodies reactive with endotoxin core
Buy PDF- 7pp USH1198  1993-06 Larrich et al.  Cetus Corporation Pseudomonas aeruginosa type-specific human monoclonal antibodies, their preparation and use
       
Foreign References:
Buy
PDF		 Publication Date IPC Code Assignee   Title
Get PDF - 31pp EP0101039 1984-02  A61K 38/00 MEIJI SEIKA KABUSHIKI KAISHA Monoclonal antibody, method of producing the same and use thereof 
Get PDF - 45pp EP0163493 1985-12  C12P 21/00 GENETIC SYSTEMS CORP Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production 
Get PDF - 31pp EP0174204 1986-03  A61K 38/00 CETUS CORPORATION Gram-negative bacterial endotoxin blocking monoclonal antibodies and cellsproducing the same and formulations containing the same, and the production of all thereof 
Get PDF - 41pp EP0176365 1986-04  C07K 15/00 SUMITOMO CHEMICAL CO Human monoclonal antibody and its preparation 
Get PDF - 12pp EP0183876 1986-06  A61K 38/00 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Monoclonal antibodies for endotoxin core and their use 
Buy PDF- 48pp WO8404458 1984-11  A61K 39/395 HUNTER KENNETH W MONOCLONAL ANTIBODIES REACTIVE WITH ENDOTOXIN CORE 
Buy PDF- 82pp WO8501659 1985-04  A61K 38/00 CENTOCOR INC MONOCLONAL ANTIBODIES AGAINST ENDOTOXIN OF GRAM-NEGATIVE BACTERIA 
Buy PDF- 37pp WO8603754 1986-07  A61K 38/00 KAWAMURA, Takashi ANTI-PSEUDOMONAS AERUGINOSA HUMAN MONOCLONAL ANTIBODY 


Other Abstract Info: CHEMABS 107(05)037948U DERABS C1987-095524

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