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This patent was reissued on Aug. 15, 2006 as patent
USRE39240
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 Title: |
US5700778:
Conotoxins I
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Olivera, Baldomero M.; Salt Lake City, UT
Rivier, Jean E.F.; La Jolla, CA
Cruz, Lourdes J.; Salt Lake City, UT
Abogadie, Fe; Evanston, IL
Hopkins, Chris E.; Salt Lake City, UT
Dykert, John; Vista, CA
Torres, Josep L.; Barcelona, Spain
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| Assignee: |
The Salk Institute for Biological Studies, La Jolla, CA
University of Utah Research Foundation, Salt Lake City, UT
other patents from SALK INSTITUTE FOR BIOLOGICAL STUDIES (490315) (approx. 349)
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| Published / Filed: |
1997-12-23
/ 1995-06-02
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| Application Number: |
US1995000458499
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| IPC Code: |
Advanced:
C07K 14/435;
C12N 15/12;
A61K 38/00;
A61K 39/00;
Core:
more...
IPC-7:
C07K 7/08;
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| ECLA Code: |
C07K14/435A;
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| U.S. Class: |
Current:
514/012;
514/013;
514/014;
530/324;
530/325;
530/326;
Original:
514/012;
530/324;
530/326;
530/325;
514/013;
514/014;
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| Field of Search: |
514/012,13,14
530/324,325,326
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| Government Interest: |
This invention was made with Government support under Grant Nos. GM-22737 and AM-26741, awarded by the National Institutes of Health. The Government has certain rights in this invention.
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| Priority Number: |
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| Abstract: |
Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defense genes into plant species of interest.
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| Attorney, Agent or Firm: |
Fitch, Even, Tabin & Flannery ;
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| Primary / Asst. Examiners: |
Tsang, Cecilia J.; Delaney, Patrick R.
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| INPADOC Legal Status: |
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| Parent Case: |
This is a division of application Ser. No. 08/084,848, filed on Jun. 29, 1993, now U.S. Pat. No. 5,432,155.
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| Designated Country: |
AT BE CH DE DK FR GB IT LI LU NL SE AU CA EP JP KR
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| Family: |
Show 49 known family members
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First Claim:
Show all 8 claims |
What is claimed is:
1. A substantially pure conotoxin which is highly selective for a specific human receptor, which conotoxin is selected from the group consisting of:
- Gly-Xaa-Ser-Phe-Cys-Lys-Ala-Asp-Glu-Lys-Xaa-Cys-Glu-Tyr-His-Ala-Asp-Cys-Cys-Asn-Cys-Cys-Leu-Ser-Gly-Ile-Cys-Ala-Xaa-Ser-Thr-Asn-Trp-Ile-Leu-Pro-Gly-Cys-Ser-Thr-Ser-Ser-Phe-Phe-Lys-Ile (SEQ ID NO:7) wherein Xaa is 4Hyp;
- Gly-Cys-Cys-Ser-His-Pro-Ala-Cys-Ser-Gly-Lys-Tyr-Gln-Xaa-Tyr-Cys-Arg-Xaa-Ser (SEQ ID NO:8) wherein Xaa is Gla and the C-terminus is amidated;
- His-Xaa-Xaa-Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr-Xaa-Gly-Cys-Ser-Ser-Ala-Ser-Cys-Cys-Gln (SEQ ID NO:9) wherein Xaa is 4Hyp;
- Cys-Lys-Thr-Tyr-Ser-Lys-Tyr-Cys-Xaa-Ala-Asp-Ser-Xaa-Cys-Cys-Thr-Xaa-Gln-Cys-Val-Arg-Ser-Tyr-Cys-Thr-Leu-Phe (SEQ ID NO:10) wherein Xaa is Gla and the C-terminus is amidated;
- Ser-Thr-Ser-Cys-Met-Glu-Ala-Gly-Ser-Tyr-Cys-Gly-Ser-Thr-Thr-Arg-Ile-Cys-Cys-Gly-Tyr-Cys-Ala-Tyr-Phe-Gly-Lys-Lys-Cys-Ile-Asp-Tyr-Pro-Ser-Asn (SEQ ID NO:11);
- Gly-Glu-Xaa-Xaa-Val-Ala-Lys-Met-Ala-Ala-Xaa-Leu-Ala-Arg-Xaa-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro (SEQ ID NO:12) wherein Xaa is Gla; and
- Glu-Ser-Glu-Glu-Gly-Gly-Ser-Asn-Ala-Thr-Lys-Lys-Pro-Tyr-Ile-Leu (SEQ ID NO:13), wherein Glu in the 1-position is pGlu and the C-terminus is amidated.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 6 U.S. patent(s) that reference this one
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