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 Title: |
US5708145:
Immunglobulins reactive with protegrins
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Lehrer, Robert I.; Santa Monica, CA
Harwig, Sylvia S.L.; Woodland Hills, CA
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| Assignee: |
University of California, Los Angeles, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1998-01-13
/ 1994-05-17
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| Application Number: |
US1994000243879
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| IPC Code: |
Advanced:
A01N 63/02;
C07K 7/08;
C07K 16/18;
A61K 38/00;
Core:
C07K 7/00;
more...
IPC-7:
C07K 16/44;
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| ECLA Code: |
A01N63/02; C07K7/08A; C07K16/18;
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| U.S. Class: |
Current:
530/387.1;
530/387.9;
530/388.1;
530/388.85;
Original:
530/387.1;
530/387.9;
530/388.85;
530/388.1;
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| Field of Search: |
530/387.1,387.9,388.85,388.1
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| Government Interest: |
This invention was made with funding from NIH Grant No. A122839. The U.S. Government has certain rights in this invention.
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| Priority Number: |
| 1994-05-17 |
US1994000243879 |
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| Abstract: |
Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula:
A1 -A2 -A3 -A4 -A5 -C-A7 -C-A9 -A10 -A11 -A12 -C-A14 -C-A16 -(A17 -A18)(1)
- and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, either in optionally --SH stabilized linear or in cystine-bridged form
- wherein A1 and A9 are basic amino acids;
- A2, A3 and A10 are small amino acids;
- A5, A7, A12, A14 and A16 are hydrophobic amino acids; and
- A4 is a basic or a small amino acid;
- A11 is a hydrophobic amino acid;
- A17 is not present or, if present, is a small amino acid;
- A18 is not present or, if present, is a basic amino acid, and
- modified form of formula (1) wherein each of 1-4 cysteines is independently replaced by a hydrophobic amino acid or a small amino acid.
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| Attorney, Agent or Firm: |
Morrison & Foerster LLP ;
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| Primary / Asst. Examiners: |
Eisenschenk, Frank C.;
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This is a Continuation-In-Part of U.S. Ser. No. 08/182,483 filed 13 Jan. 1994 now pending which is a Continuation-In-Part of U.S. Ser. No. 08/095,769 filed 26 Jul. 1993 now U.S. Pat. No. 5,464,823, which is a Continuation-In-Part of U.S. Ser. No. 08/093,926 filed 20 Jul. 1993, now abandoned. The contents of these applications are incorporated herein by reference.
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| Designated Country: |
BB BG BR BY CA CN CZ FI HU KP KR KZ LK LV MG MN MW NO NZ OA PL BE CH FR GB GR IE IT LI LU MC NL
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| Family: |
Show 35 known family members
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First Claim:
Show all 6 claims |
We claim:
1. Antibodies specifically reactive with a compound of the formula (1)
A1 -A2 -A3 -A4 -A5 -C-A7 -C-A9 -A10 -A11 -A12 -C-A14 -C-A16 -(A17 -A18)(1)
- and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, which is either in the optionally --SH stabilized linear or in the cystine-bridged form
- wherein A1 and A9 are basic amino acids;
- A2, A3 and A10 are small amino acids;
- A5, A7, A12, A14 and A16 are hydrophobic amino acids; and
- A4 is a basic or a small amino acid;
- A11 is a hydrophobic amino acid;
- A17 is not present or, if present, is a small amino acid;
- A18 is not present or, if present, is a basic amino acid, or a modified form of formula (1) and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof wherein each of 1-4 cysteines is independently replaced by a hydrophobic amino acid or a small amino acid.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 9 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 122(19)230760Q
CHEMABS 128(11)127091X
CHEMABS 124(09)106630Z
CHEMABS 128(05)045808X
CHEMABS 128(11)127091X
CHEMABS 129(18)225713S
CHEMABS 132(01)002807M
DERABS C1995-075188
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| Other References: |
Tamamura, H., et al ., "A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide . . . " Biochimica et Biophysica Acta 1163:209-216 (1993).
(8 pages)
Cited by 12 patents
[ISI abstract]
Tamamura, H., et al ., "Antimicrobial Activity and Conformation of Tachyplesin I and Its Analogs" Chem. and Pharmaceutical Bulletin 41 (5):978-980 (1993).
(3 pages)
Cited by 12 patents
[ISI abstract]
Olsson et al. [Biochem. Biophy. Acta 1097:37-44 (1991)].
(8 pages)
Cited by 6 patents
[ISI abstract]
Lerner [Nature 299:592-596 (1992)].
Lehrer et al., Direct Inactivation of Viruses by MCP-1 and MCP-2 Natural Peptide Antibiotics from Rabbit Leukocytes; J. Virol. (1985) 54:467-472.
(6 pages)
Cited by 15 patents
Kokryakov et al., Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins adn tachyplesins; FEBS (1993) 327:231-236.
(6 pages)
Cited by 19 patents
[ISI abstract]
Mirgorodskaya, et al., Primary structure of three cationic peptides from porcine neutrophils; FEBS (1993) 330:339-342.
(4 pages)
Cited by 14 patents
[ISI abstract]
Storici, et al., A Novel cDNA Sequence Encoding a Pih Leukocyte Antimicrobial Peptide with a Cathelin-like Pro-sequence; Biochem. Biophys. Res. Comm. (1993) 196:1363-1367.
(6 pages)
Cited by 14 patents
[ISI abstract]
Nakashima et al., Anti-Human Immunodeficiency Virus Activity of a Novel Synthetic Peptide, T22 ([Tyr-5, 12, Lys-7]Polyphemusin II): a Possible Inhibitor of Virus-Cell Fusion, Antimicrobial Agents and Chemotherapy (1992) 1249-1255.
(7 pages)
Cited by 13 patents
[ISI abstract]
Lehrer et al., Defensins: Endogenous Antibiotic Peptides of Animal Cells, Cell (1991) 64:229-230.
(2 pages)
Cited by 32 patents
[ISI abstract]
Lehrer et al., Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells, Annual Review Immunol (1993) 11:105-1288.
(24 pages)
Cited by 26 patents
[ISI abstract]
Selsted et al., Purification, Primary Structures, and Antibacterial Activities of β-Defensins, a New Family of Antimicrobial Peptides from Bovine Neutrophils, J. Biol Chem (1993) 288:6641--6648.
(8 pages)
Cited by 23 patents
[ISI abstract]
Diamond et al., Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA, Proc. Natl. Acad. Sci. (USA) (1991) 88:3952-3958.
(5 pages)
Cited by 26 patents
[ISI abstract]
Lambert et al., Insect Immunity: Isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides, Proc. Natl. Acad. Sci. (USA) (1989) 88:262-265.
(5 pages)
Cited by 11 patents
Broekaert et al., Antimicrobial Peptides from Amaranthus caudatus Seeds with Sequence Homology tothe Cysteine/Glycine-Rich Domain o Chitin-Binding Proteins, Biochemistry (1992) 31:4308-4314.
(7 pages)
Cited by 22 patents
[ISI abstract]
Cornelissen et al., Strategies for Control of Fungal Disease with Transgenic Plants, Plant Physiol (1993) 101:709-712.
(4 pages)
Cited by 22 patents
[ISI abstract]
Haln et al., Disease resistance results from foreign phytoalexin expression in a novel plant, Nature (1993) 361:153-156.
Rustici et al., Molecular Mapping and Detoxification of the Lipid A Binding Site by Synthetic Pepides; Science (1993) 259:361-364.
(5 pages)
Cited by 19 patents
[ISI abstract]
Matsuzaki et al., Role of Disulfide Linkages in Tachytoplesin--Lipid Interactions; Biochemistry (1993) 32:11704-11710.
(7 pages)
Cited by 10 patents
[ISI abstract]
Hoess et al., Crystal structure of an endotoxin-neutralizing protein from teh horseshoe crab, Limulus anti-LPS factor, at 1.4 .ANG. resolution; EMBO J. (1993) 12:3351-3356.
(6 pages)
Cited by 20 patents
[ISI abstract]
Elsbach et al., Bactericidal/permeability increasing protein and host defense against Gram-negative bacteria and endotoxin; Current Opinion in Immunology (1993) 5:103-107.
(5 pages)
Cited by 14 patents
[ISI abstract]
Mirgorodskaya et al.; Primary structure of three cationic peptides from porcine neutrophils; FEBS 330(3):339-342.
Selsted et al.; Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils; J. Biol. Chem. 260(8):4579-4584.
Nakamura et al., Tachyplesin, a Class of Antimicorbial Peptide from the Hemocytes of the Horseshoe Crab (Tachypleus tridentatus), J. Biol. Chem. (1988) 263:16709-16713.
(5 pages)
Cited by 28 patents
Miyata et al., Antimicrobial Peptides, Isolated from Horseshoe Crab Hemocytes, Tachyplesin II, and Polyphemusins I and II: Chemical Structures and Biological Activity, J. Biochem; (1989) 106:663-668.
(6 pages)
Cited by 18 patents
Murakami et al., Direct Virus Inactivation of Tachyplesin I and Its Isopeptides from Horseshoe Crab Hemocytes, Chemotherapy (1991) 37:327-334.
(8 pages)
Cited by 16 patents
[ISI abstract]
Morimoto et al., Inhibitory Effect of Tachyplesin I on the Proliferation of Human Immunodeficiency Virus in vitro, Chemotherapy (1991) 37:206-211.
(6 pages)
Cited by 14 patents
[ISI abstract]
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| Continuity Data: |
| Application Number | Filed | Notes |
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US2003000627829 | 2003-07-24 | is a
continuation of |
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US2000000539443
| 2000-03-30 |
(abandoned)
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US2000000539443 | 2000-03-30 | is a
continuation of |
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US1998000128345
| 1998-08-03 |
(granted)
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US6159936 issued 2000-12-12 Compositions and methods for treating and preventing microbial and viral infections
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US1998000128345 | 1998-08-03 | is a
division of |
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US1995000499523
| 1995-07-07 |
(granted)
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US1998000128345 | 1998-08-03 | is a
continuation of |
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US1995000499523
| 1995-07-07 |
(granted)
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US1998000128345 | 1998-08-03 | is a
division of |
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US1995000451832
| 1995-05-26 |
(abandoned)
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US1995000499523 | 1995-07-07 | is a
continuation in part of |
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US1995000451832
| 1995-05-26 |
(abandoned)
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US1998000128345 | 1998-08-03 | is a
division of |
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>US1994000243879<
| 1994-05-17 |
(granted)
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US5708145 issued 1998-01-13 Immunglobulins reactive with protegrins
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US1995000451832 | 1995-05-26 | is a
continuation in part of |
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>US1994000243879<
| 1994-05-17 |
(granted)
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| |
US5708145 issued 1998-01-13 Immunglobulins reactive with protegrins
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US1998000128345 | 1998-08-03 | is a
division of |
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US1994000182483
| 1994-01-13 |
(granted)
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US5693486 issued 1997-12-02 DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
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>US1994000243879< | 1994-05-17 | is a
continuation in part of |
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US1994000182483
| 1994-01-13 |
(granted)
|
| |
US5693486 issued 1997-12-02 DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
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|
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US1998000128345 | 1998-08-03 | is a
division of |
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US1993000095769
| 1993-07-26 |
(granted)
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US5464823 issued 1995-11-07 Mammalian antibiotic peptides
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US1994000182483 | 1994-01-13 | is a
continuation in part of |
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US1993000095769
| 1993-07-26 |
(granted)
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US5464823 issued 1995-11-07 Mammalian antibiotic peptides
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|
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US1998000128345 | 1998-08-03 | is a
division of |
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US1993000093926
| 1993-07-20 |
(abandoned)
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US1993000095769 | 1993-07-26 | is a
continuation in part of |
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US1993000093926
| 1993-07-20 |
(abandoned)
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