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 Title: |
US5719264:
Conotoxin peptides
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Shon, Ki-Joon; Salt Lake City, UT
Olivera, Baldomero M.; Salt Lake City, UT
McIntosh, J. Michael; Salt Lake City, UT
Hasson, Arik; Jerusalem, Israel
Spira, Micha E.; Jerusalem, Israel
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| Assignee: |
Univ. of Utah Research Foundation, Salt Lake City, UT
Yissum Research Development Co. of the Hebrew University of Jerusalem, Jerusalem, Israel
other patents from UNIVERSITY OF UTAH RESEARCH FOUNDATION (600050) (approx. 286)
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| Published / Filed: |
1998-02-17
/ 1994-10-07
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| Application Number: |
US1994000319554
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| IPC Code: |
Advanced:
C07K 14/435;
Core:
more...
IPC-7:
A61K 38/00;
C07K 5/00;
C07K 7/00;
C07K 16/00;
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| ECLA Code: |
C07K14/435A;
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| U.S. Class: |
Current:
530/324;
Original:
530/324;
514/012;
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| Field of Search: |
530/324
514/012
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| Government Interest: |
This invention was made with Government support under Grant Nos. GM-48677 and NS-27219 awarded by the National Institutes of Health, Bethesda, Md. The United States Government has certain rights in the invention.
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| Priority Number: |
| 1994-10-07 |
US1994000319554 |
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| Abstract: |
The present invention is directed to conotoxin peptides having 25-35 amino acids, six cysteines which form three disulfide bonds between the first and fourth, second and fifth, and third and sixth cysteines, respectively. The invention is directed to δ-conotoxin GmVIA having the formula Val-Lys-Pro-Cys-Arg-Lys-Glu-Gly-Gln-Leu-Cys-Asp-Pro-Ile-Phe-Gln-Asn-Cys-Cys-Arg-Gly-Trp-Asn-Cys-Val-Leu-Phe-Cys-Val (SEQ ID NO:1). This peptide activates sodium channels. The invention is further directed to µO-conotoxin peptides of the generic formula Ala-Cys-Xaa1 -Lys-Lys-Trp-Glu-Tyr-Cys-Ile-Val-Pro-Ile-Xaa2 -Gly-Phe-Xaa3 -Tyr-Cys-Cys-Pro-Gly-Leu-Ile-Cys-Gly-Pro-Phe-Val-Cys-Val, wherein Xaa1 is Arg or Ser, Xaa2 is Ile or Leu and Xaa3 is Ile or Val (SEQ ID NO:2). These peptides block sodium charmels. Examples of µO-conotoxin peptides of the present invention are MrVIA, having the formula Ala-Cys-Arg-Lys-Lys-Trp-Glu-Tyr-Cys-Ile-Val-Pro-Ile-Ile-Gly-Phe-Ile-Tyr-Cys-Cys-Pro-Gly-Leu-Ile-Cys-Gly-Pro-Phe-Val-Cys-Val (SEQ ID NO:3), and MrVIB, having the formula Ala-Cys-Ser-Lys-Lys-Trp-Glu-Tyr-Cys-Ile-Val-Pro-Ile-Leu-Gly-Phe-Val-Tyr-Cys-Cys-Pro-Gly-Leu-Ile-Cys-Gly-Pro-Phe-Val-Cys-Val (SEQ ID NO:4).
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| Attorney, Agent or Firm: |
Rothwell, Figg, Ernst & Kurz, P.C. ;
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| Primary / Asst. Examiners: |
Tsang, Cecilia J.; Harle, Jennifer
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| INPADOC Legal Status: |
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| Family: |
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First Claim:
Show all 10 claims |
What is claimed is:
1. A substantially pure δ-conotoxin GmVIA having the formula Val-Lys-Pro-Cys-Arg-Lys-Glu-Gly-Gln-Leu-Cys-Asp-Pro-Ile-Phe-Gln-Asn-Cys-Cys-Arg-Gly-Trp-Asn-Cys-Val-Leu-Phe-Cys-Val (SEQ ID NO:1).
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 6 U.S. patent(s) that reference this one
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