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Title: US5721209: Iron chelator and inhibitor of iron-mediated oxidant injury
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Country: US United States of America

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15 pages

 
Inventor: Horwitz, Lawrence D.; Engelwood, CA
Horwitz, Marcus A.; Los Angeles, CA
Gibson, Bradford W.; Berkeley, CA
Reeve, Joseph; Oakhurst, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1998-02-24 / 1995-02-03

Application Number: US1995000383180

IPC Code: Advanced: A01N 1/02; A61K 31/55;
Core: more...
IPC-7: A61K 38/12;

ECLA Code: A01N1/02; A61K31/55+A;

U.S. Class: Current: 514/011; 435/071.2; 435/118; 435/120; 435/863; 435/864; 435/865; 435/866; 514/017; 514/018; 530/317; 530/329; 530/330; 540/524; 540/526;
Original: 514/011; 514/017; 514/018; 530/317; 530/329; 530/330; 435/071.2; 435/118; 435/120; 435/863; 435/864; 435/865; 435/866; 540/524; 540/526;

Field of Search: 514/011,17,18 530/317,329,330 435/863,864,865,866,71.2,118,120 540/524,526

Priority Number:
1995-02-03  US1995000383180

Abstract:     Exochelins can be used to prevent damage to living tissue from the formation or presence of the (.OH) radical. In particular, the invention is directed to the administration of exochelins to infarcted myocardium prior to or coincidental with reperfusion to prevent damage to myocardium from iron mediated free radical formation. Also presented is the chemical structure of exochelins and modified exochelins as well as other applications of these materials in the treatment and diagnosis of disease in mammals.

Attorney, Agent or Firm: Ram, Michael J. ; Kleinberg, Marvin H. ; Lerner, Marshall A. ;

Primary / Asst. Examiners: Krass, Frederick;

Maintenance Status: CC Certificate of Correction issued
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Designated Country: AL AM AP AZ BB BG BR BY EE FI GE IS JP KG KP KR KZ LK LR LT LV  AT BE CH DE DK ES FR GB GR IE IT LI LU 

Family: Show 45 known family members

First Claim:
Show all 13 claims
What is claimed is:     1. A composition for protecting live tissue in a mammal from injury resulting from exposure to the hydroxyl free radical formed following reestablishment of fluid flow to a body organ after restriction of blood flow to that body organ comprising an effective amount of a lipid and water soluble desferriexochelin, said amount being effective to protect said mammal upon the reestablishment of flow of fluid to the tissue.

Background / Summary: Show background / summary

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Description: Show description

Forward References: Show 14 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (14)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 125(23)293041P DERABS C96-371116

Other References:
  • Chemical Abstracts 108:218746, "Mycobactins and Exochelins", Barclay et al., 1988.
  • Chemical Abstracts 98:157511, "Iron-Binding Compounds", Barclay et al., 1983.
  • Kirschner, Richard and Gary Fantini, "Role of Iron and Oxygen-Derived Free Radicals in Ischemia-Reperfusion Injury," Journal of The American College of Surgeons, vol. 179, No. 1, pp. 103-117, (Jul. 1994). (15 pages) [ISI abstract]
  • Scheibel and Stanton, "Antimalarial Activity of Selected Aromatic Chelators. IV. Cation Uptake by Plasmodium falciparum in the Presence of Oxines and Siderochromes," Molecular Pharmacology: An International Journal, vol. 30, No. 4, pp. 364-369, (Oct. 1986). (6 pages) Cited by 3 patents
  • Sharman, Williams, Ewing and Ratledge, "Isolation, purification and structure of exochelin MS, the extracellular siderophore from Mycobacterium smegmatis," Biochemical Journal, pp. 187-196, (Jan. 1, 1995). (10 pages) [ISI abstract]
  • Barclay, Raymond and Colin Ratledge, "Iron-Binding Compounds of Mycobacterium avium, M. intracellulare, M. scrofulaceum, and Mycobactin-Dependent M. paratuberculosis and M. avium," Journal of Bacteriology, pp. 1138-1146, (Mar. 1983). (9 pages)
  • Barclay and Ratledge, "Metal Analogues of Mycobactin and Exochelin Fail to Act as Effective Antimycobacterial Agents," Zbl. Bakt. Hyg. A 262, 203-207 (1986). (5 pages)
  • Barclay and Ratledge, "Mycobactins and Exochelins of Mycobacterium tuberculosis, M. bovis, M. africanum and Other Related Species," Journal of General Microbiology, 134, 771-776 (1988). (6 pages) Cited by 2 patents
  • Byler, Richard M. et al., "Hydrogen peroxide cytotoxicity in cultured cardiac myocytes is iron dependent," American Physiological Society, (1994).
  • Fiss, Ellen H. et al., "Identification of genes involved in the sequestration of iron in mycobacteria: the ferric exochelin biosynthetic and uptake pathways," Molecular Microbiology, 14(3), 557-569 (1994). (13 pages) Cited by 3 patents [ISI abstract]
  • Gibson, Bradford W. et al. "Iron-Binding Exochelins" fromMycobacterium Tuberculosis: Structure, Characterization and Drug Design, In: Program of the Third International Symposium on Mass Spectrometry in the Health and Life Sciences (Sep. 13-18, 1994).
  • Hall, Richard Malcolm et al, "Exochelin-mediated Iron Uptake into Mycobacterium leprae," International Journal of Leprosy, vol. 51, No. 4, (1983).
  • Horwitz, Lawrence D. et al., "Marked Reduction in Myocardial Infarct Size Due to Prolonged Infusion of an Antioxidant During Reperfusion," Circulation 89:1792-1801, (Apr. 1994). (10 pages) Cited by 2 patents [ISI abstract]
  • Kubica, George P. and Lawrence G. Wayne (Editors), The Mycobacteria: A Sourcebook, Published by Marcel Dekker, Inc., New York and Basel, Part A, pp. 606-627.
  • Lesnefsky, Edward J. et al., "Deferoxamine Pretreatment Reduces Canine Infarct Size and Oxidative Injury," The Journal of Pharmacology and Experimental Therapeutcs, vol. 253, No. 3, 1103-1109 (1990). (7 pages) Cited by 2 patents
  • Macham, L.P. and Ratledge, "A New Group of Water-soluble Iron-binding Compounds from Mycobacteria: The Exochelins," Journal of General Microbiology, 89, 379-382 (1975). (4 pages) Cited by 2 patents
  • Macham, Ratledge and Nocton, "Extracellular Iron Acquisition by Mycobacteria: Role of the Exochelins and Evidence Against the Participation of Mycobactin," Infection and Immunity, vol. 12, No. 6, pp. 1242-1251 (Dec. 1975). (10 pages) Cited by 2 patents
  • Ratledge, C., "Iron metabolism in Mycobacterium," Iron Transport in Microbes, Plants and Animals, pp. 207 233 (1987).
  • Sritharan, M. and Colin Ratledge, "Co-ordinated expression of the components of iron transport (mycobactin, exochelin and envelope proteins) in Mycobacterium neoaurum," FEMS Microbiology Letters, 60 (1989) 183-186. (4 pages)
  • Stephenson, Maris C. and Colin Ratledge, "Specificity of Exochelins for Iron Transport in Three Species of Mycobacteria," Journal of General Microbiology, 116, 521-523 (1980). (3 pages)
  • Wheeler, PR and C Ratledge, "Metabolism in Mycobacterium leprae, M. tuberculosis and other pathogenic mycobacteria," British Medical Bulletin, vol.44, No. 3, pp. 547-561 (1988). (15 pages)


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