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Title: US5739276: Conotoxin peptides
[ Derwent Title ]

Country: US United States of America

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23 pages

 
Inventor: Shon, Ki-Joon; Shaker Heights, OH
Grilley, Michelle M.; Salt Lake City, UT
Olivera, Baldomero M.; Salt Lake City, UT

Assignee: University of Utah Research Foundation, Salt Lake City, UT
other patents from UNIVERSITY OF UTAH RESEARCH FOUNDATION (600050) (approx. 286)
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Published / Filed: 1998-04-14 / 1996-03-29

Application Number: US1996000624123
IPC Code: Advanced: C07K 14/435; A61K 38/00;
Core: more...
IPC-7: A61K 38/17; C07K 14/435;

ECLA Code: C07K14/435; C07K14/435A;

U.S. Class: Current: 530/324;
Original: 530/324; 514/012; 514/021;

Field of Search: 530/324 514/012,21

Government Interest:     This invention was made with Government support under Grant No. POI GM 28677 awarded by the National Institutes of Health, Bethesda, Md. The United States Government has certain rights in the invention.

Priority Number:
1996-03-29  US1996000624123

Abstract: The present invention is directed to δ-conotoxin PVIA having the formula Glu-Ala-Cys-Tyr-Ala-Xaa1 -Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa2 -Gly-Leu-Cys-Cys-Ser-Glu-Phe-Cys-Leu-Pro-Gly-Val-Cys-Pro-Gly (Xaa1 or Xaa2 is Pro or 4-trans-hydroxyproline) (SEQ ID NO:7). The C-terminus may be free or amidated. This latter conotoxin is vertebrate-specific which targets voltage-sensitive Na channels.

Attorney, Agent or Firm: Rothwell, Figg, Ernst & Kurz, P.C. ;

Primary / Asst. Examiners: Russel, Jeffrey E.;

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Related Applications:
Application Number Filed Patent Pub. Date  Title
US1995000423561 1995-04-17       
US1994000319554 1994-10-07       


       
Parent Case:

CROSS-REFERENCE TO RELATED APPLICATION
    The present application is a continuation-in-part of application Ser. No. 08/423,561 filed 17 Apr. 1995, now abandoned, which is a continuation-in-part of application Ser. No. 08/319,554 filed 7 Oct. 1994, which are incorporated herein by reference.

Designated Country: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE  AU CA EP JP 

Family: Show 11 known family members
First Claim:
Show all 9 claims		 What is claimed is:     1. A substantially pure δ-conotoxin PVIA peptide having the formula Glu-Ala-Cys-Tyr-Ala-Xaa1 -Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa2 -Gly-Leu-Cys-Cys-Ser-Glu-Phe-Cys-Leu-Pro-Gly-Val-Cys-Pro-Gly (SEQ ID NO:7), wherein Xaa1 and Xaa2 are independently Pro or 4-trans-hydroxyproline.

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Forward References: Show 10 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (10)   |   Backward references (7)   |   Citation Link

Buy
PDF		 Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 10pp US4447356  1984-05 Olivera et al.   Conotoxins
Buy PDF- 29pp US5051403  1991-09 Miljanich et al.  Neurex Corporation Method of treating ischemia-related neuronal damage
Buy PDF- 32pp US5189020  1993-02 Miljanich et al.  Neurex Corporation Method of reducing neuronal damage using omega conotoxin peptides
Buy PDF- 31pp US5264371  1993-11 Miljanich et al.  Neurex Corporation Screening method for neuroprotective compounds
Buy PDF- 31pp US5424218  1995-06 Miljanich et al.  Neurex Corporation Screening method for neuroprotective compounds
Buy PDF- 15pp US5432155  1995-07 Olivera et al.  The Salk Institute For Biological Studies Conotoxins I
Buy PDF- 32pp US5514774  1996-05 Olivera et al.  University of Utah Research Foundation Conotoxin peptides
       
Foreign References:
Buy
PDF		 Publication Date IPC Code Assignee   Title
Buy PDF- 105pp WO9310145 1993-05  A61K 38/00 BITNER, Robert, S. COMPOSITIONS FOR DELAYED TREATMENT OF ISCHEMIA-RELATED NEURONAL DAMAGE 
Buy PDF- 92pp WO9313128 1993-07  A61K 38/00 GOHIL, Kishor, Chandra METHODS OF PRODUCING ANALGESIA AND ENHANCING OPIATE ANALGESIA 
Buy PDF- 67pp WO9511256 1995-04  C07K 7/08 UNIVERSITY OF UTAH RESEARCH FOUNDATION CONOTOXIN PEPTIDES 


Other Abstract Info: CHEMABS 128(17)201058K CHEMABS 128(24)299517G CHEMABS 128(24)299517G DERABS C1996-485724 DERABS C2000-095638

Other References:
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  • Colledge, C.J. et al. (1992). "Precursor Structure of ω-Conotoxin GVIA Determined from a cDNA Clone," Toxicon 30:1111-1116. (6 pages) Cited by 4 patents [ISI abstract]
  • Cruz, L.J. and Olivera, B.M. (1986). "Calcium Channel Antagonists. ω-Conotoxin Defines a New High Affinity Site," J. Biol. Chem. 261:6230-6233. (4 pages) Cited by 4 patents
  • Dudley, S.C. et al. (1995). "A µ-Conotoxin-Insensitive Na+ Channel Mutant: Possible Localization of a Binding Site at the Outer Vestibule," Biophysical J. 69:1657-1665. (9 pages) Cited by 3 patents [ISI abstract]
  • Fainzilber, M. et al. (1991). "Mollusc-specific toxins from the venom of Conus textile neovicarius," Eur. J. Biochem. 202:589-595. (7 pages) Cited by 7 patents [ISI abstract]
  • Fainzilber, M. et al. (1994). "A New Neurotoxin Receptor Site on Sodium Channels Is Identified by a Conotoxin That Affects Sodium Channel Inactivation in Molluscs and Acts as an Antagonist in Rat Brain," J. Biol. Chem. 269:2574-2580. (7 pages) Cited by 4 patents [ISI abstract]
  • Fainzilber, M. et al. (1994). "New Mollusc-Specific α-Conotoxins Block Aplysia Neuronal Acetylcholine Receptors," Biochemistry 33:9523-9529. (7 pages) Cited by 5 patents [ISI abstract]
  • Gray, W.R. et al. (1981). "Peptide Toxins from Conus geographus Venom," J. Biol. Chem. 256:4734-4740. (7 pages) Cited by 14 patents
  • Hasson, A. et al. (1993). "Alteration of Sodium Currents by New Peptide Toxins From the Venom of a Molluscivorous Conus Snail," Eur. J. Neurosci. 5:56-64. (9 pages) Cited by 3 patents [ISI abstract]
  • Hillyard, D.R. et al. (1989). "A Molluscivorous Conus Toxin: Conserved Frameworks in Conotoxins," Biochemistry 28:358-361. (4 pages) Cited by 13 patents
  • Hillyard, D.R. et al. (1992). "A New Conus Peptide Ligand for Mammalian Presynaptic Ca2+ Channels," Neuron 9:69-77. (9 pages) Cited by 4 patents [ISI abstract]
  • Hopkins, C. et al. (1995). "A New Family of Conus Peptides Targeted to the Nicotinic Acetylcholine Receptor," J. Biol. Chem. 270:22361-22367. (7 pages) Cited by 3 patents [ISI abstract]
  • Kobayashi, J. et al. (1982). "Isolation of a Cardiotonic Glycoprotein, Striatoxin, from the Venom of the Marine Snail Conus Striatus," Biochem. Biophys. Res. Comm. 105:1389-1395. (7 pages) Cited by 3 patents
  • Lundy, P.M. et al. (1991). "Pharmacological evidence for an ω-conotoxin, dihydropyridine-insensitive neuronal Ca2+ channel," Eur. J. Pharmacol. 206:61-68. (8 pages) Cited by 4 patents [ISI abstract]
  • McCleskey, E.W. et al. (1987). "ω-Conotoxin: Direct and persistent blockade of specific types of calcium channels in neurons but not muscle," Proc. Natl. Acad. Sci. USA 84:4327-4331. (5 pages) Cited by 8 patents
  • McIntosh, M. et al. (1982). "Isolation and Structure of a Peptide Toxin from the Marine Snail Conus magus," Arch. Biochem. Biophys. 218:329-334. (6 pages) Cited by 8 patents
  • McIntosh, J.M. et al. (1995). "A New Family of Conotoxins That Blocks Voltage-gated Sodium Channels," J. Biol. Chem. 270:16796-16802. (7 pages) Cited by 3 patents [ISI abstract]
  • Monje, V.D. et al. (1993). "A New Conus Peptide Ligand For Ca Channel Subtypes," Neuropharmacology 32:1141-1149. (9 pages) Cited by 10 patents [ISI abstract]
  • Myers, R.A. et al. (1993). "Conus Peptides as Chemical Probes for Receptors and Ion Channels," Chem. Rev. 93:1923-1936. (14 pages) Cited by 14 patents [ISI abstract]
  • Olivera, B.M. et al. (1984). "Purification and Sequence of a Presynaptic Peptide Toxin from Conus geographus Venom," Biochemistry 23:5087-5090. (4 pages) Cited by 13 patents
  • Olivera, B.M. et al. (1985). "Peptide Neurotoxins from Fish-Hunting Cone Snails," Science 230:1338-1343. (6 pages) Cited by 25 patents
  • Olivera, B.M. et al. (1987). "Neuronal Calcium Channel Antagonists. Discrimination between Calcium Channel Subtypes Using ω-Conotoxin from Conus magus Venom," Biochemistry 26:2086-2090. (5 pages) Cited by 19 patents
  • Olivera, B.M. et al. (1990). "Diversity of Conus Neuropeptides," Science 249:257-263. (7 pages) Cited by 36 patents
  • Olivera, B.M. et al. (1991). "Conotoxins," J. Biol. Chem. 266:22067-22070. (4 pages) Cited by 30 patents [ISI abstract]
  • Ramilo, C.A. et al. (1992). "Novel α-and ω-Conotoxins from Conus striatus Venom," Biochemistry 31:9919-9926. (8 pages) Cited by 5 patents [ISI abstract]
  • Regan, L.J. et al. (1991). "Ca2+ Channels in Rat Central and Peripheral Neurons: High-Threshold Current Resistant to Dihydropyridine Blockers and ω-Conotoxin," Neuron 6:269-280. (12 pages) Cited by 3 patents [ISI abstract]
  • Rivier, J. et al. (1987). "Neuronal Calcium Channel Inhibitors. Synthesis of ω-Conotoxin GVIA and Effects on 45 Ca Uptake by Synaptosomes," J. Biol. Chem. 262:1194-1198. (5 pages) Cited by 11 patents
  • Shon, K-J. et al. (1994). "δ-Conotoxin GmVIA, a Novel Peptide from the Venom of Conus gloriamaris," Biochemistry 33:11420-11425. (6 pages) Cited by 4 patents [ISI abstract]
  • Shon, K-J. et al. (1995). "Purification, Characterization, Synthesis, and Cloning of the Lockjaw Peptide from Conus purpurascens Venom," Biochemistry 34:4913-4918. (6 pages) Cited by 3 patents [ISI abstract]
  • Spira, M.E. et al. (1993). "Chemical and Electrophysiological Characterization of New Peptide Neurotoxins form the Venom of the Molluscivorous Snail Conus textile neovicarius: A Review," Isr. J. Med. Sci. 29:530-543. (14 pages) Cited by 3 patents [ISI abstract]
  • Woodward, S.R. et al. (1990). "Constant and hypervariable regions in conotoxin propeptides," EMBO J. 9:1015-1020. (6 pages) Cited by 10 patents
  • Yoshikami, D. et al. (1989). "The Inhibitory Effects of Omega-Conotoxins on Ca Channels and Synapses," Ann. N.Y. Acad. Sci. 560:230-248. (19 pages) Cited by 4 patents
  • Fainzilber, M. et al. (1995). "A New Conotoxin Affecting Sodium Current Inactivation Interacts with the δ-Conotoxin Receptor Site," J. Biol. Chem. 270:1123-1129. (7 pages) Cited by 3 patents [ISI abstract]


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