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 Title: |
US5756300:
Oligodendrocyte-specific protein and method for diagnosing and treating disease
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Seitz, Robert S.; Huntsville, AL
Lallone, Roger L.; Birmingham, AL
Bronstein, Jeff M.; Santa Monica, CA
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| Assignee: |
Research Genetics, Inc., Huntsville, AL
University of California at Los Angeles, Los Angeles, CA
other patents from RESEARCH GENETICS, INC. (741104) (approx. 1)
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| Published / Filed: |
1998-05-26
/ 1995-11-14
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| Application Number: |
US1995000557917
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| IPC Code: |
Advanced:
C07K 14/47;
C07K 16/18;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
G01N 33/53;
G01N 33/536;
G01N 33/537;
G01N 33/567;
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| ECLA Code: |
C07K14/47A5; C07K16/18;
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| U.S. Class: |
Current:
435/007.1;
435/007.2;
435/007.21;
435/331;
436/536;
436/538;
530/388.2;
Original:
435/007.1;
435/007.2;
435/007.21;
435/331;
436/536;
436/538;
530/388.2;
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| Field of Search: |
435/7.1,7.2,7.21,326,331
436/536,538
530/387.9,388.2
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| Priority Number: |
| 1995-11-14 |
US1995000557917 |
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| Abstract: |
A protein consisting essentially of purified oligodendrocyte-specific protein or purified biologically active variants thereof, or a combination of purified oligodendrocyte-specific protein and biologically active variants thereof. A purified and isolated peptide having the sequence Ala-Lys-Tyr-Arg-Arg-Ala-Gln-Leu-Ala-Gly residues 115-124 of SEQ ID NO:2. A device for identifying an epitope region of a peptide, protein, or protein homologue of interest comprising a polypropylene membrane having a plurality of sequentially oriented peptide spots, each spot containing a peptide having an amino acid sequence where the amino acid sequences of the peptides on the peptide spots sequentially progress through the amino acid sequence of the peptide, protein, or protein homologue of interest. A method of diagnosing multiple sclerosis and a method of treating multiple sclerosis. A method of diagnosing a disease or condition, such as an autoimmune disease, the disease or condition having the clinical feature of antibody production against a peptide, protein, or protein homologue.
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| Attorney, Agent or Firm: |
Farah, David A.Sheldon & Mak ;
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| Primary / Asst. Examiners: |
Hutzell, Paula K.; Navarro, Mark
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DK EE FI GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT DE ES FR GB IT
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| Family: |
Show 7 known family members
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First Claim:
Show all 6 claims |
We claim:
1. A method to assist in the diagnosis of multiple sclerosis comprising the steps of:
- (a) providing a sample of tissue or fluid from a patient;
- (b) determining immunoreactivity of the sample to a peptide having the sequence Ala-Lys-Tyr-Arg-Arg-Ala-Gln-Leu-Ala-Gly (residues 115-124 of SEQ ID NO:2); and
- (c) comparing the determined immunoreactivity to an immunoreactivity of one or more subjects known to have multiple sclerosis or one or more subjects known not to have multiple sclerosis;
wherein an immunoreactivity of the patient sample above the range of the subject or subjects known not to have multiple sclerosis, or an immunoreactivity of the patient sample in the range of the subject or subject known to have multiple sclerosis indicates that the patient has multiple sclerosis.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 4 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
DERABS C1997-289056
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| Other References: |
Sevier, E.D. et al., "Monoclonal Antibodies in Clinical Immunology," Clinical Chemistry 27(11):1797-1805 (1981).
(10 pages)
Cited by 283 patents
Xie, D. et al., "The oligodendroglial reaction to brain stab wounds: an immunohistochemical study," Journal of Neurocytology 24:435-448 (1995).
(14 pages)
Cited by 3 patents
[ISI abstract]
Schaeren-Wiemers, N. et al., "Identification of New Oligodendrocyte-and Myelin-Specific Genes by a Differential Screening Approach," Journal of Neurochemistry 65(1):10-22.
Schaefer et al., "The C-DNA of COP, A novel oligodendrocyte-specific protein," Experientia 49:A66 (1993).
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