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 Title: |
US5780433:
Use of α-conotoxin MII to treat disorders resulting from nicotine stimulated dopamine release
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
McIntosh, J. Michael; Salt Lake City, UT
Kulak, Jennifer M.; Salt Lake City, UT
Yoshikami, Doju; Salt Lake City, UT
Olivera, Baldomero M.; Salt Lake City, UT
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| Assignee: |
University of Utah Research Foundation, Salt Lake City, UT
other patents from UNIVERSITY OF UTAH RESEARCH FOUNDATION (600050) (approx. 286)
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| Published / Filed: |
1998-07-14
/ 1996-12-06
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| Application Number: |
US1996000761674
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| IPC Code: |
Advanced:
A61K 38/17;
Core:
more...
IPC-7:
A61K 38/00;
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| ECLA Code: |
A61K38/17;
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| U.S. Class: |
Current:
514/013;
514/813;
Original:
514/013;
514/813;
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| Field of Search: |
514/013,813
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| Government Interest: |
This invention was made with Government support under Grant Nos. MH 53631 and GM 48677, awarded by the National Institutes of Health, Bethesda, Md. The United States Government has certain rights in the invention.
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| Priority Number: |
| 1996-12-06 |
US1996000761674 |
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| Abstract: |
Neuronal nicotinic acetylcholine receptors (nAChRs) are believed to mediate nicotine addiction. In addition, stimulation of nAChRs modulates release of neurotransmitters including dopamine, norepinephrine and serotonin. Thus, pharmacological manipulation of nicotinic receptors has implications for a wide variety of disorders including psychotic, mood, movement and cognitive. For most nAChRs, there are no subtype selective ligands. However, α-conotoxin MII, a small peptide from the carnivorous marine snail Conus magus, was recently isolated. This peptide has been shown to be a specific antagonist for α3β2 nicotinic receptors. The peptide potently blocks part, but not all, of nicotine-stimulated dopamine release from rat brain striatal synaptosomes. In contrast it has no effect on potassium stimulated dopamine release. Other α-conotoxins specifically target distinct neuronal nAChR subtypes. α-Conotoxins thus represent new lead compounds for CNS disorders.
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| Attorney, Agent or Firm: |
Rothwell, Figg, Ernst & Kurz, P.C. ;
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| Primary / Asst. Examiners: |
Cook, Rebecca;
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE EP ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT
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| Family: |
Show 5 known family members
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First Claim:
Show all 5 claims |
What is claimed is:
1. A method to aid a person who smokes nicotine containing products to quit smoking said nicotine containing products wherein said method comprises a step of administering α-conotoxin MII to said person wherein said α-conotoxin MII is administered in an amount which is effective to aid said person to quit smoking said nicotine containing products.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 2 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 129(04)037452G
DERABS C98-333038
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| Other References: |
Tennant et al. NIDA Res. Monogr., 49, 239, 1984.
Tennant et al, NIDA Res. Monogr, 55, 291-297, 1984.
Rose et al, Pharmacol. Bioch. & Behav, 32, 933-938, 1989.
(6 pages)
Cited by 2 patents
Rose et al, Clin. Pharmacol. & Therapeutics, 56(1), 86-98, Jul. 1994.
(14 pages)
Cited by 4 patents
[ISI abstract]
Benwell et al, Br. J. Pharmacol, 117, 743-749, Feb. 1996.
(7 pages)
[ISI abstract]
Corrigall et al, Psychopharmacol., 99, 473-478, 1989.
(6 pages)
Cited by 2 patents
Glick et al, Nature, 227, 969-970, 1970.
Stolerman et al, Psycho Pharmacologia, 28, 247-259, 1973.
(13 pages)
Cited by 4 patents
Harvey et al, 26 Annual Meeting of Society for Neurosc. 22 (1-3) p. 1259, Nov. 1996.
Cartier et al, J. Biol. Chem. 271 (13) pp. 7522-7528, Mar. 29, 1996.
(7 pages)
Cited by 4 patents
[ISI abstract]
Corrigall et al, Psychopharmacology, 104, 171-176, 1991.
(6 pages)
Cited by 3 patents
[ISI abstract]
Corrigall et al, Brain Research, 653, 278-284, 1994.
(7 pages)
Cited by 2 patents
[ISI abstract]
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