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 Title: |
US5789189:
Inhibition of cyst formation by cytoskeletal specific drugs
[ Derwent Title ]
>> View Certificate of Correction for this publication
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| Country: |
US United States of America
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| Inventor: |
Woo, David D. L.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1998-08-04
/ 1995-05-22
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| Application Number: |
US1995000406910
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| IPC Code: |
Advanced:
C12N 5/06;
G01N 33/50;
Core:
more...
IPC-7:
C12N 5/00;
C12Q 1/02;
C12Q 1/10;
C12Q 1/24;
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| ECLA Code: |
C12N5/06B12K; G01N33/50D2;
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| U.S. Class: |
Current:
435/030;
435/004;
435/029;
435/039;
435/041;
435/354;
435/383;
435/395;
436/063;
514/462;
514/629;
540/478;
549/345;
Original:
435/030;
435/029;
435/039;
435/004;
435/240.2;
435/240.23;
435/041;
436/063;
514/462;
514/629;
540/004.78;
549/345;
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| Field of Search: |
435/030,29,39,4,41,240.2,240.23
436/063,64,74
514/352,462,629
530/350
540/478
549/345
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| Government Interest: |
STATEMENT OF UNITED STATES GOVERNMENT SUPPORT
Certain aspects of this invention were made with United States government funding under NIH Grant No. DK 40700. The United States government has certain rights in these aspects of the invention in the United States.
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| Priority Number: |
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| Abstract: |
The invention provides a method of producing a culture of polycystic kidney cells which form cysts in vitro. A cell culture of polycystic kidney cells is also provided. A method for screening an agent in vitro to determine the effectiveness of the agent in treating polycystic kidney disease is disclosed. Further, a method of treating a mammal having polycystic kidney disease by administering a pharmaceutical composition is provided.
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| Attorney, Agent or Firm: |
Knobbe Martens Olson & Bear, LLP ;
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| Primary / Asst. Examiners: |
Leary, Louise;
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| Maintenance Status: |
CC Certificate of Correction issued
View Certificate of Correction
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
AU CA EP JP US DE ES FR GB IT
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| Family: |
Show 6 known family members
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First Claim:
Show all 27 claims |
What is claimed is:
1. A method of producing a culture of polycystic kidney cells which form cysts in vitro, comprising:
- preparing a suspension of polycystic kidney cells that form cysts in vivo in a medium suitable for the maintenance of said cells; and
- culturing said cells on a solid phase which substantially prevents the formation of a layer of said cells on the surface of said solid phase.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| PCT Number: |
PCT/US93/09124
WO9408041
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| PCT Pub./Filed Dates: |
1994-04-14 / 1993-09-24
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| § 371 / 102(e) Dates: |
1995-05-22 / 1995-05-22
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| Forward References: |
Show 5 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 121(07)073915D
DERABS C1994-135601
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| Other References: |
Siegal, et al., Transplantation; vol. 54, No. 3; 1992; p. 1131; The polycystic kidney donor. Month not available.
(1 pages)
Cited by 2 patents
[ISI abstract]
Merck & Co., Budavari, S.Ed.: The Merck Index; 1989; p. 1435. Month not available.
Woo; Journal of American Society of Nephrology; vol. 3, No. 3, 1992; p. 302; Cytoskeletal specific drugs inhibit in-vitro cyst formation. Month not available.
Ravia, et al.; Human Genetics; vol. 71, No. 4, 1985; pp. 294-300; Differences between cystic fibrosis and normal cells in the degree of satelite association. Month not available.
(7 pages)
Cited by 2 patents
Forrest; Biochemical and Biophysical Research Communications; vol. 98, No. 1; Jan. 15, 1981; pp. 324-329; Colchicine Binding activity and Tyrosyl tubulin ligase activity in normal and cystic fibrosis fibroblasts.
Rubino et al, Europ J Cell Biology, vol. 30, pp. 182-190 (1983). Month no available.
(9 pages)
Cited by 2 patents
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