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This patent was reissued on May 29, 2001 as patent
USRE37194

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Title: |
US5798035:
High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
[ Derwent Title ]

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Country: |
US United States of America

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Inventor: |
Kirk, Gregory L.; Skillman, NJ
Grubbs, Robert H.; South Pasadena, CA

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Assignee: |
Pharmacopeia, Inc., Princeton, NJ
other patents from PHARMACOPEIA, INC. (729286) (approx. 71)
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Published / Filed: |
1998-08-25
/ 1996-10-03

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Application Number: |
US1996000726058

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IPC Code: |
Advanced:
B01J 19/00;
C07K 1/04;
G01N 30/46;
C40B 60/14;
C40B 70/00;
G01N 30/52;
G01N 30/60;
Core:
C07K 1/00;
G01N 30/00;
more...
IPC-7:
C25B 15/02;

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ECLA Code: |
G01N30/46E; B01J19/00C; C07K1/04B; L01J219/00C2B2D; L01J219/00C2B4; L01J219/00C2B4B; L01J219/00C2B4D2; L01J219/00C2D2B; L01J219/00C2D12; L01J219/00C2D16; L01J219/00C2H2B2; L01J219/00C2K; L01J219/00C2L2; L01J219/00C2L6; L01J219/00C2L7F; L01J219/00C2N6; L01J219/00C4B; L01J219/00C4D; L01J219/00C4F; L01J219/00C4H; L01J219/00C4L2; L01J219/00C4L12; L01J219/00C6F2; L01J219/00C6P; L01J219/00C8B; M40B60/14; M40B70/00; S01N30/52C; S01N30/60+S01N30/46E; S01N30/60B4; Y01N6/00; L01J219/00C4L3B;

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U.S. Class: |
Current:
506/004;
205/335;
206/305;
206/459.5;
422/055;
422/056;
422/057;
422/059;
422/063;
422/082;
422/119;
422/129;
422/138;
422/188;
422/196;
422/197;
422/232;
422/233;
422/236;
436/047;
436/048;
436/049;
436/052;
436/055;
436/165;
436/169;
506/031;
506/037;
Original:
205/335;
422/055;
422/056;
422/057;
422/059;
422/063;
422/082;
422/119;
422/129;
422/138;
422/188;
422/196;
422/197;
422/232;
422/233;
422/236;
436/052;
436/055;
436/047;
436/048;
436/049;
436/165;
436/169;
206/305;
206/459.5;

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Field of Search: |
422/055,56,57,58,59,63,82,119,129,138,188,196,197,232,233,234,236
206/568,569,305,459.5
436/044,52,55,47,48,49,165,169,523,527,528,518,531,535
205/335

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Priority Number: |
| 1996-10-03 |
US1996000726058 |

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Abstract: |
A high throughput chemical synthesis system utilizing cylindrical reaction vessels is disclosed. Reaction vessels are utilized which include a tubular member adapted for placement of electronically readable identifying indicia thereon. The identifying indicia are representative of reaction conditions within the tubular member and of one or more reagents utilized in a reaction within the tubular members. A method of performing chemical synthesis on solid phase reactive material within a plurality of reaction vessels using a plurality of reaction stages resulting in final products and employing identifying indicia representing the reaction stages is also disclosed. The method includes reading the identifying indicia located on the reaction vessels, reacting one or more reagents within the reaction vessels under particular reaction conditions which may be determined by reading the identifying indicia, thereby synthesizing chemical compounds within the reaction vessels. The method allows chemical synthesis to occur according to a predetermined set of reactions and also allows for combinatorial chemistry to be performed utilizing random mix and split techniques. The final synthesized products may be tested for chemical or biological activity. The chemical structures of desired end products may be obtained by reading recorded information wherein the reaction conditions and reagents of reaction steps have been recorded, preferably in conjunction with the identifying indicia.

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Attorney, Agent or Firm: |
Heslin & Rothenberg, P.C. ;

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Primary / Asst. Examiners: |
Bell, Bruce F.;

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Maintenance Status: |
E2 Expired Check current status

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INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report

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Designated Country: |
AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE EP ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU

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Family: |
Show 4 known family members

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First Claim:
Show all 78 claims |
What is claimed is:
1. A method of performing chemical synthesis on solid phase reactive material contained within a plurality of tubular reaction vessels, using one or more reaction stages, resulting in a plurality of final products and employing identifying indicia to represent specific reactions and reagents utilized during said one or more reaction stages, said method comprising:
- reading said identifying indicia provided for each of a plurality of tubular reaction vessels,
- reacting a reagent with said reactive material by flowing a reagent-containing solution through said tubular reaction vessels under particular reaction conditions, wherein said reacting is driven to completion within the reactive material by said flowing of reagent-containing solution through said tubular reaction vessels without agitation of said reactive material;
- recording information concerning said reaction conditions and reagents, said information corresponding to said identifying indicia; and
- repeating said reading and said reacting at least once using a different reagent, thereby synthesizing chemical compounds within said tubular reaction vessels.

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Background / Summary: |
Show background / summary

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Drawing Descriptions: |
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Description: |
Show description

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Forward References: |
Show 30 U.S. patent(s) that reference this one

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Foreign References: |

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Other Abstract Info: |
CHEMABS 128(24)292525Z
DERABS C1998-240215

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Other References: |
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Chemical Abstracts, vol. 66, 1967, Abstract No. 18845b. No Month Available.
Chemical Abstracts, vol. 122, 1995, Abstract No. 10543f.; Abstract No. 10640k; Abstract No. 31956h No Month Available.
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Chemical Abstracts vol. 101, 1984, Abstract No. 73078v; vol. 102, 1985 Abs. No. 149758k.

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