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  This patent was reissued on May 29, 2001 as patent USRE37194

Title: US5798035: High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
[ Derwent Title ]


Country: US United States of America

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21 pages

 
Inventor: Kirk, Gregory L.; Skillman, NJ
Grubbs, Robert H.; South Pasadena, CA

Assignee: Pharmacopeia, Inc., Princeton, NJ
other patents from PHARMACOPEIA, INC. (729286) (approx. 71)
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Published / Filed: 1998-08-25 / 1996-10-03

Application Number: US1996000726058

IPC Code: Advanced: B01J 19/00; C07K 1/04; G01N 30/46; C40B 60/14; C40B 70/00; G01N 30/52; G01N 30/60;
Core: C07K 1/00; G01N 30/00; more...
IPC-7: C25B 15/02;

ECLA Code: G01N30/46E; B01J19/00C; C07K1/04B; L01J219/00C2B2D; L01J219/00C2B4; L01J219/00C2B4B; L01J219/00C2B4D2; L01J219/00C2D2B; L01J219/00C2D12; L01J219/00C2D16; L01J219/00C2H2B2; L01J219/00C2K; L01J219/00C2L2; L01J219/00C2L6; L01J219/00C2L7F; L01J219/00C2N6; L01J219/00C4B; L01J219/00C4D; L01J219/00C4F; L01J219/00C4H; L01J219/00C4L2; L01J219/00C4L12; L01J219/00C6F2; L01J219/00C6P; L01J219/00C8B; M40B60/14; M40B70/00; S01N30/52C; S01N30/60+S01N30/46E; S01N30/60B4; Y01N6/00; L01J219/00C4L3B;

U.S. Class: Current: 506/004; 205/335; 206/305; 206/459.5; 422/055; 422/056; 422/057; 422/059; 422/063; 422/082; 422/119; 422/129; 422/138; 422/188; 422/196; 422/197; 422/232; 422/233; 422/236; 436/047; 436/048; 436/049; 436/052; 436/055; 436/165; 436/169; 506/031; 506/037;
Original: 205/335; 422/055; 422/056; 422/057; 422/059; 422/063; 422/082; 422/119; 422/129; 422/138; 422/188; 422/196; 422/197; 422/232; 422/233; 422/236; 436/052; 436/055; 436/047; 436/048; 436/049; 436/165; 436/169; 206/305; 206/459.5;

Field of Search: 422/055,56,57,58,59,63,82,119,129,138,188,196,197,232,233,234,236 206/568,569,305,459.5 436/044,52,55,47,48,49,165,169,523,527,528,518,531,535 205/335

Priority Number:
1996-10-03  US1996000726058

Abstract:     A high throughput chemical synthesis system utilizing cylindrical reaction vessels is disclosed. Reaction vessels are utilized which include a tubular member adapted for placement of electronically readable identifying indicia thereon. The identifying indicia are representative of reaction conditions within the tubular member and of one or more reagents utilized in a reaction within the tubular members. A method of performing chemical synthesis on solid phase reactive material within a plurality of reaction vessels using a plurality of reaction stages resulting in final products and employing identifying indicia representing the reaction stages is also disclosed. The method includes reading the identifying indicia located on the reaction vessels, reacting one or more reagents within the reaction vessels under particular reaction conditions which may be determined by reading the identifying indicia, thereby synthesizing chemical compounds within the reaction vessels. The method allows chemical synthesis to occur according to a predetermined set of reactions and also allows for combinatorial chemistry to be performed utilizing random mix and split techniques. The final synthesized products may be tested for chemical or biological activity. The chemical structures of desired end products may be obtained by reading recorded information wherein the reaction conditions and reagents of reaction steps have been recorded, preferably in conjunction with the identifying indicia.

Attorney, Agent or Firm: Heslin & Rothenberg, P.C. ;

Primary / Asst. Examiners: Bell, Bruce F.;

Maintenance Status: E2 Expired  Check current status

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Designated Country: AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE EP ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU 

Family: Show 4 known family members

First Claim:
Show all 78 claims
What is claimed is:     1. A method of performing chemical synthesis on solid phase reactive material contained within a plurality of tubular reaction vessels, using one or more reaction stages, resulting in a plurality of final products and employing identifying indicia to represent specific reactions and reagents utilized during said one or more reaction stages, said method comprising:
  • reading said identifying indicia provided for each of a plurality of tubular reaction vessels,
  • reacting a reagent with said reactive material by flowing a reagent-containing solution through said tubular reaction vessels under particular reaction conditions, wherein said reacting is driven to completion within the reactive material by said flowing of reagent-containing solution through said tubular reaction vessels without agitation of said reactive material;
  • recording information concerning said reaction conditions and reagents, said information corresponding to said identifying indicia; and
  • repeating said reading and said reacting at least once using a different reagent, thereby synthesizing chemical compounds within said tubular reaction vessels.


Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 30 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (30)   |   Backward references (26)   |   Citation Link

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PDF
Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 9pp US3531258  1970-09 Merrifield et al.   APPARATUS FOR THE AUTOMATED SYNTHESIS OF PEPTIDES
Buy PDF- 11pp US3951741  1976-04 Pfaender et al.   Process and apparatus for the synthesis of peptides by use of n-carboxyanhydrides
Buy PDF- 16pp US4252769  1981-02 Hood et al.  California Institute of Technology Apparatus for the performance of chemical processes
Buy PDF- 7pp US4351762  1982-09 Verlander et al.  BioResearch, Inc. Rapid, quantitative peptide synthesis using mixed anhydrides
Buy PDF- 6pp US4362699  1982-12 Verlander et al.  Bio Research, Inc. Apparatus for high pressure peptide synthesis
Buy PDF- 25pp US4552922  1985-11 Patchornik et al.  Yeda Research & Development Co. Ltd. Method for multipolymer synthesis of organic compounds
Buy PDF- 23pp US4631211  1986-12 Houghten  Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
Buy PDF- 29pp US4746490  1988-05 Saneii   Solid phase peptide synthesizer
Buy PDF- 17pp US4800166  1989-01 Horn et al.  Applied Protein Technologies, Inc. Method and apparatus for monitoring the automated synthesis of peptides
Buy PDF- 31pp US4816513  1989-03 Bridgham et al.  Applied Biosystems, Inc. Automated polypeptide synthesis process
Buy PDF- 12pp US4861866  1989-08 Durrum et al.  Eldex Laboratories, Inc. Continuous flow peptide synthesizer
Buy PDF- 9pp US5102986  1992-04 Coffey et al.  Wolverhampton Polytechnic Higher Education Corporation Method for carrying out organic chemical reactions and appartaus for carrying out that method
Buy PDF- 9pp US5169935  1992-12 Hoeger et al.  The Salk Institute for Biological Studies Method of making peptides
Buy PDF- 30pp US5186898  1993-02 Bridgham et al.  Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
Buy PDF- 7pp US5188733  1993-02 Wang et al.  Trustees of Boston University Apparatus and process for effecting sequential peptide syntheses
Buy PDF- 9pp US5202418  1993-04 Lebl et al.  Ceskoslovenska akademie ved Method of performing multiple synthesis of peptides on solid carrier
Buy PDF- 20pp US5258454  1993-11 Berg et al.  Riso National Laboratory Peptide synthesis method and solid support for use in the method
Buy PDF- 9pp US5286789  1994-02 Okrongly et al.  Applied Immune Sciences, Inc. Solid phase multiple peptide synthesis
Buy PDF- 6pp US5318679  1994-06 Nishioka  H & N Instruments, Inc. Synthesis of chain chemical compounds
Buy PDF- 48pp US5324483  1994-06 Cody et al.  Warner-Lambert Company Apparatus for multiple simultaneous synthesis
Buy PDF- 12pp US5338831  1994-08 Lebl et al.  Academy of Sciences of the Czech Republic changed from Ceskoslovenska akademie ved Method of making multiple synthesis of peptides on solid support
Buy PDF- 16pp US5384261  1995-01 Winkler et al.  Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
Buy PDF- 11pp US5387526  1995-02 Garner et al.  General Atomics Coated capillary tube for the controlled release of reagent
Buy PDF- 19pp US5609826  1997-03 Cargill et al.  Ontogen Corporation Methods and apparatus for the generation of chemical libraries
Buy PDF- 50pp US5612002  1997-03 Cody et al.  Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
Buy PDF- 9pp US5663545  1997-09 Marquiss  LJL Biosystems Inc. Labware identification system
       
Foreign References:
Buy
PDF
Publication Date IPC Code Assignee   Title
Buy PDF CA1312991 1993-01  C08F 212/08 BIO-MEGA INC. SOLID SUPPORTS FOR PEPTIDE SYNTHESIS 
Buy PDF- 17pp EP0274999A2 1987-12  C07K 1/00 MONSANTO COMPANY Resin support for solid phase peptide synthesis 
Buy PDF- 13pp EP0355266A2 1989-04  B01J 19/00 MILLIPORE CORP Apparatus and process for performing repetitive chemical reactions 
Buy PDF- 53pp WO8805074 1988-07  B01J 19/00 BAYLOR COLLEGE MEDICINE POROUS WAFER FOR SEGMENTED SYNTHESIS OF BIOPOLYMERS 
Buy PDF- 110pp WO9200091 1992-01  A61K 37/02 BIOLIGAND INC RANDOM BIO-OLIGOMER LIBRARY, A METHOD OF SYNTHESIS THEREOF, AND A METHOD OF USE THEREOF 
Buy PDF- 32pp WO9222591 1992-12  C07C 17/00 RESEARCH & DIAGNOSTIC ANTIBODIES POLYMERIC RESIN FOR PEPTIDE SYNTHESIS 
Buy PDF- 20pp WO9302992 1993-02  B01J 19/00 H & N INSTRUMENTS, INC. SYNTHESIS OF CHAIN CHEMICAL COMPOUNDS 
Buy PDF- 53pp WO9305065 1993-03  C07F 7/00 PORTON DEVELOPMENTS LIMITED PREPARATION OF PEPTIDES BY A SOLID-PHASE SYNTHESIS AND INTERMEDIATES THEREFOR 
Buy PDF- 35pp WO9312427 1993-06  B01J 19/00 CHIRON CORPORATION AUTOMATED APPARATUS FOR USE IN PEPTIDE SYNTHESIS 
Buy PDF- 25pp WO9317056 1993-09  C07K 1/00 NEW YORK UNIVERSITY METHOD FOR PREPARATION OF PEPTIDE SYNTHESIS RESINS AND NOVEL PEPTIDE SYNTHESIS RESINS 
Buy PDF- 50pp WO9405394 1994-03  B01D 25/12 ARRIS PHARM CORP SPECIFICATION METHOD AND APPARATUS FOR PEPTIDE SYNTHESIS AND SCREENING 
Buy PDF- 148pp WO9408051 1994-04  C12Q 1/68 COLD SPRING HARBOR LAB COMPLEX COMBINATORIAL CHEMICAL LIBRARIES ENCODED WITH TAGS 


Other Abstract Info: CHEMABS 128(24)292525Z DERABS C1998-240215

Other References:
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