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 Title: |
US5804553:
Prophenins - antibiotic peptides
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kokryakov, Vladimir N.; Los Angeles, CA
Harwig, Sylvia S. L.; Woodland Hills, CA
Lehrer, Robert I.; Santa Monica, CA
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| Assignee: |
University of California, Los Angeles, CA
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| Published / Filed: |
1998-09-08
/ 1994-04-05
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| Application Number: |
US1994000222798
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| IPC Code: |
Advanced:
A01N 63/02;
C07K 14/47;
C12N 15/82;
Core:
C07K 14/435;
more...
IPC-7:
A61K 38/08;
A61K 38/17;
C07K 14/47;
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| ECLA Code: |
A01N63/02; C07K14/47; C12N15/82C8B6;
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| U.S. Class: |
Current:
514/012;
514/015;
530/300;
530/324;
530/328;
Original:
514/072;
530/300;
530/324;
530/328;
514/015;
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| Field of Search: |
514/012,15
530/324,300,328
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| Government Interest: |
This invention was made with funding from NIH Grant No. A122839. The U.S. Government has certain rights in this invention.
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| Priority Number: |
| 1994-04-05 |
US1994000222798 |
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| Abstract: |
Peptide-based compounds containing multiple proline residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection, especially Gram-negative bacterial infection in animals and plants, in treating conditions characterized by the presence of LPS. These compounds are of the formula [Figure] including the N-terminal acylated and/or C-terminal amidated or esterified forms thereof
- wherein each of A1, A5, A10, A14 and A20 is independently Ala, Gly or Ser;
- each of A2, A4, A7, A9, A11, A12, A13, A16, A17, A19 and A22 is independently a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met;
- each of A3 and A8 is independently a neutral polar amino acid selected from Asn and Gln or is a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met;
- each of A6, A18 and A21 is independently a basic amino acid selected from Arg, Lys, and Har; and
- wherein A15 is Trp or a basic amino acid selected from Lys, Arg and Har;
- wherein n is an integer of 1-6; and
- the antimicrobial or LPS-binding fragments thereof. Recombinant materials for the production of these peptides are also disclosed.
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| Attorney, Agent or Firm: |
Morrison & Foerster LLP ;
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| Primary / Asst. Examiners: |
Wax, Robert A.; Lau, Kawai
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
AU CA EP JP
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| Family: |
Show 5 known family members
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First Claim:
Show all 6 claims |
We claim:
1. A peptide in purified and isolated form wherein said peptide comprises the amino acid sequence of Sequence ID NO: 1.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 7 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 124(03)025496H
DERABS C1995-358444
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| Other References: |
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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Cited by 19 patents
[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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(6 pages)
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[ISI abstract]
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(6 pages)
Cited by 18 patents
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(4 pages)
Cited by 14 patents
[ISI abstract]
Murakami, T. et al., Direct Virus Inactivation of Tachyplesin I and Its Isopeptides from Horseshoe Crab Hemocytes, Chemotherapy (1991) 37:327-334.
(8 pages)
Cited by 16 patents
[ISI abstract]
Morimoto, M. et al., Inhibitory Effect of Tachyplesin I on the Proliferation of Human Immunodeficiency Virus in vitro, Chemotheraphy (1991) 37:206-211.
(6 pages)
Cited by 14 patents
[ISI abstract]
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(5 pages)
Cited by 28 patents
Nakashima, H. et al., Anti-Human Immunodeficiency Virus Activity of a Novel Synthetic Peptide, T22 ([Tyr-5,12, Lys-7]Polyphemiusin II): a Possible Inhibitor of Virus-Cell Fusion, Antimicrobial Agents and Chemotherapy (1992) 1249-1255.
(7 pages)
Cited by 13 patents
[ISI abstract]
Pungercar, J. et al., Molecular Cloning of a Putative Homolog of Proline/arginine-rich Antibacterial Peptides from Porcine Bone Marrow, FEBS (1993) 336:284-288.
(5 pages)
Cited by 6 patents
[ISI abstract]
Selsted, M.E. et al., Purification, Primary Structures, and Antibacterial Activities of β-Defensins, a New Family of Antimicrobial Peptides from Bovine Neutrophils, J Biol Chem (1993) 288:6641-6648.
(8 pages)
Cited by 23 patents
[ISI abstract]
Storici, P. et al., A Novel cDNA Sequence Encoding a Pig Leukocyte Antimicrobial Peptide with a Cathelin-like Pro-sequence, Biochem Biophys Res Commun (1993) 196:1363-1368.
(6 pages)
Cited by 14 patents
[ISI abstract]
Storici, P., et al., cDNA Sequence Analysis of an Antibiotic Dodecapeptide from Neutrophils, FEBS (1992) 314:187-190.
(4 pages)
Cited by 4 patents
[ISI abstract]
Storici, P. et al., A cDNA Derived from Pig Bone Marrow Cells Predicts a Sequence Identical to the Intestinal Antibacterial Peptide PR-391, Biochem Biophys Res Commun (1993) 196:1058-1065.
(8 pages)
Cited by 3 patents
[ISI abstract]
Tang, Y-Q., et al., Characterization of the Disulfide Motif in BNBD-12, an Antimicrobial β-Defensin Peptide form Bovine Neutrophils, J Biol Chem (1993) 268:6649-6653.
(5 pages)
Cited by 10 patents
[ISI abstract]
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(12 pages)
Cited by 7 patents
[ISI abstract]
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(5 pages)
Cited by 5 patents
[ISI abstract]
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(5 pages)
Cited by 7 patents
[ISI abstract]
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