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Title: US5804558: Protegrins
[ Derwent Title ]

Country: US United States of America

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76 pages

 
Inventor: Lehrer, Robert I.; Santa Monica, CA
Harwig, Sylvia S. L.; Woodland Hills, CA
Kokryakov, Vladimir N.; St. Petersburg, Russian Federation

Assignee: University of California, Los Angeles, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1998-09-08 / 1995-07-07

Application Number: US1995000499523
IPC Code: Advanced: A01N 63/02; C07K 7/08; C07K 16/18; C12N 15/12; A61K 38/00;
Core: C07K 7/00; more...
IPC-7: A01N 25/00; A61K 38/04; C12N 15/12; C12N 15/13;

ECLA Code: A01N63/02; C07K7/08A; C07K16/18;

U.S. Class: Current: 514/013; 424/405; 435/069.1; 435/252.3; 435/320.1; 530/326; 536/023.5;
Original: 514/013; 530/326; 424/405; 536/023.5; 435/069.1; 435/252.3; 435/320.1; 935/009; 935/027; 935/066;

Field of Search: 530/326,324,300,325 435/69.1,252.3,69.7,320.1 536/23.5,23.4 514/013,2 424/405

Government Interest:     This invention was made with funding from NIH Grant No. A122839. The U.S. Government has certain rights in this invention.

Priority Number:
1995-07-07  US1995000499523

Abstract: Peptide-based compounds containing four invariant cycteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula: [Figure] and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, which is either in the optionally -SH stabilized linear or in a cystine-bridged form
  • wherein each of A1 and A9 is independently a basic amino acid;
  • each of A2 and A3 is independently a small amino acid;
  • each of A5, A7, A12, A14 and A16 is independently a hydrophobic amino acid;
  • A4 is a basic or a small amino acid;
  • A10 is a basic or a small amino acid or is proline;
  • A11 is a basic or a hydrophobic amino acid;
  • A17 is not present or, if present, is a small amino acid;
  • A18, is not present or, if present, is a basic amino acid; or a
  • modified form of formula (1) and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof wherein each of 1-4 cysteines is independently replaced by a hydrophobic amino acid or a small amino gacid.


    •
Attorney, Agent or Firm: Pennie & Edmonds LLP ;

Primary / Asst. Examiners: Wax, Robert A.; Moore, William W.
INPADOC Legal Status: None          Buy Now: Family Legal Status Report

       
Related Applications: Go to Result Set: 6 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1995000451832 1995-05-26       
US1994000243879 1994-05-17    1998-01-13  Immunglobulins reactive with protegrins
US1994000182483 1994-01-13    1997-12-07  DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
US1993000095769 1993-07-26    1995-11-07  Mammalian antibiotic peptides
US1993000093926 1993-07-20       


       
Parent Case:     This application is a continuation-in-part of U.S. Ser. No. 08/451,832 filed 26 May, 1995, and now abandoned which is a continuation-in-part of U.S. Ser. No. 08/243,879 filed 17 May, 1994, and issued as U.S. Pat. No. 5,708,145 on Jan. 13, 1998, which is a continuation-in-part of U.S. Ser. No. 08/182,483 filed 13 Jan., 1994, and issued as U.S. Pat. No. 5,693,486 on Dec. 7, 1997, which is a continuation-in-part of U.S. Ser. No. 08/095,769 filed 26 Jul., 1993, and issued as U.S. Pat. No. 5,464,823 on Nov. 7, 1995, which is a continuation-in-part of U.S. Ser. No. 08/093,926 filed 20 Jul., 1993, and now abandoned. This application claims priority from PCT/US94/08305. The contents of these applications are incorporated herein by reference.

Designated Country: AL AM AP AZ BB BG BR BY CN CZ EE GE HU IS KE KG KP KR KZ LK LR LS LT  BE CH FR GB GR IE IT LI  FI 

Family: Show 65 known family members
First Claim:
Show all 63 claims		 We claim:     1. A purified and isolated or recombinantly produced compound having the formula: [Figure] or a pharmaceutically acceptable salt or an N-terminal acylated or C-terminal amidated or esterified form thereof, which is either in a linear form or in a cystine-bridged form, wherein:
  • each of A1 and A9 is independently a basic amino acid;
  • each of A2 and A3 is independently a small amino acid;
  • each of A5, A7, A12, A14 and A16 is independently a hydrophobic amino acid;
  • A4 is a basic or a small amino acid;
  • A10 is a basic or a small amino acid or is proline;
  • A11 is a basic or a hydrophobic amino acid;
  • A17 is not present or, if present, is a small amino acid;
  • A18 is not present or, if present, is a basic amino acid; and
  • each of C6, C8, C13 and C15 is independently selected from the group consisting of cysteine, a hydrophobic amino acid, a large polar amino acid and a small amino acid.
    •


Background / Summary: Show background / summary

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Description: Show description

Forward References: Show 20 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (20)   |   Backward references (18)   |   Citation Link

Buy
PDF		 Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 10pp US4543252  1985-09 Lehrer et al.  The Regents of the University of California Cationic oligopeptides having microbicidal activity
Buy PDF- 12pp US4652639  1987-03 Stabinsky  Amgen Manufacture and expression of structural genes
Buy PDF- 13pp US4659692  1987-04 Lehrer et al.  The Regents of the University of California Cationic oligopeptides having microbicidal activity
Buy PDF- 16pp US4705777  1987-11 Lehrer et al.  The Regents of the University of California Cationic oligopeptides having microbicidal activity
Buy PDF- 41pp US5087569  1992-02 Gabay et al.  Cornell Research Foundation, Inc. and The Rockefeller University Antimicrobial proteins, compositions containing same and uses thereof
Buy PDF- 35pp US5126257  1992-06 Gabay et al.  Cornell Research Foundation Antimicrobial proteins, compositions containing same and uses thereof
Buy PDF- 68pp US5171739  1992-12 Scott et al.  Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein
Buy PDF- 5pp US5234912  1993-08 Marra et al.  INCYTE Pharmaceuticals, Inc. Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof
Buy PDF- 72pp US5308834  1994-05 Scott et al.  Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and prevention thereof using a BPI protein
Buy PDF- 73pp US5334584  1994-08 Scott et al.  INCYTE Pharamaceuticals, Inc. Recombinant, non-glycosylated bpi protein and uses thereof
Buy PDF- 45pp US5338724  1994-08 Gabay et al.  Cornell Research Foundation, Inc. Antimicrobial proteins, compositions containing same and uses thereof
Buy PDF- 19pp US5422424  1995-06 Selsted et al.  The Regents of the University of California Antibiotic cryptdin peptides and methods of their use
Buy PDF- 34pp US5432270  1995-07 Zasloff et al.   DNA encoding tracheal antimicrobial peptides
Buy PDF- 37pp US5447914  1995-09 Travis et al.  Emory University Antimicrobial peptides
Buy PDF- 51pp US5458874  1995-10 Pereira et al.  Emory University Method of increasing monocyte chemotaxis with CAP37 and monocyte chemotactic portions thereof
Buy PDF- 48pp US5459235  1995-10 Selsted et al.  The Regents of the University of California Antimicrobial peptides antibodies and nucleic acid molecules from bovine neutrophils
Buy PDF- 17pp US5464823  1995-11 Lehrer et al.  The Regents of the University of California Mammalian antibiotic peptides
Buy PDF- 50pp US5484885  1996-01 Pereira et al.  Emory University Chemotactic, antibiotic and lipopolysaccharide-binding peptide fragments of CAP37
       
Foreign References:
Buy
PDF		 Publication Date IPC Code Assignee   Title
Buy PDF- 52pp EP0272489 1988-06  A61K 37/02 CORNELL RES FOUNDATION INC Antimicrobial proteins, compositions containing same and uses thereof 
Buy PDF- 10pp EP0545730 1993-06  A01N 63/02 PIONEER HI-BRED INTERNATIONAL, INC. Peptide with inhibitory activity towards plant pathogenic fungi 
Buy PDF- 34pp WO8911291 1989-11  A61K 37/02 INVITRON CORP NOVEL ANTIMICROBIAL PEPTIDE, COMPOSITIONS CONTAINING SAME AND USES THEREOF 
Buy PDF- 109pp WO9319087 1993-09  A61K 38/00 EMORY UNIVERSITY SCHOOL OF MEDICINE CHEMOTACTIC, ANTIBIOTIC AND LIPOPOLYSACCHARIDE-BINDING PEPTIDE FRAGMENTS OF CAP37 
Buy PDF- 45pp WO9324139 1993-12  A61K 37/02 SHRINER'S HOSPITAL FOR CRIPPLED CHILDREN ANTIBIOTIC CRYPTDIN PEPTIDES AND METHODS OF THEIR USE 
Buy PDF- 79pp WO9421672 1994-09  C07K 7/00 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA NOVEL ANTIMICROBIAL PEPTIDES FROM BOVINE NEUTROPHILS 
Buy PDF- 82pp WO9503325 1995-02  C07K 7/00 UNIVERSITY OF CALIFORNIA, LOS ANGELES PROTEGRINS 
Buy PDF- 39pp WO9510534 1995-04  A61K 38/00 MATSUMOTO, Akiyoshi POLYPEPTIDE AND ANTI-HIV AGENT PREPARED THEREFROM 


Other Abstract Info: CHEMABS 122(19)230760Q CHEMABS 129(18)225713S CHEMABS 124(09)106630Z CHEMABS 126(09)122456U CHEMABS 128(05)045808X CHEMABS 128(11)127091X CHEMABS 129(18)225713S CHEMABS 132(01)002807M CHEMABS 132(13)171108Q DERABS C1995-075188 DERABS C1997-033984

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    • Continuity Data:
    Application Number Filed Notes
    US2003000627829 2003-07-24  is a continuation of
    US2000000539443  2000-03-30   (abandoned)
         US20030100483A1 issued 2003-05-29   Protegrins
    US2000000539443 2000-03-30  is a continuation of
    US1998000128345  1998-08-03   (granted)
         US6159936 issued 2000-12-12   Compositions and methods for treating and preventing microbial and viral infections
    US1998000128345 1998-08-03  is a division of
    >US1995000499523<  1995-07-07   (granted)
         US5804558 issued 1998-09-08   Protegrins
    US1998000128345 1998-08-03  is a continuation of
    >US1995000499523<  1995-07-07   (granted)
         US5804558 issued 1998-09-08   Protegrins
    US1998000128345 1998-08-03  is a division of
    US1995000451832  1995-05-26   (abandoned)
    >US1995000499523< 1995-07-07  is a continuation in part of
    US1995000451832  1995-05-26   (abandoned)
    US1998000128345 1998-08-03  is a division of
    US1994000243879  1994-05-17   (granted)
         US5708145 issued 1998-01-13   Immunglobulins reactive with protegrins
    US1995000451832 1995-05-26  is a continuation in part of
    US1994000243879  1994-05-17   (granted)
         US5708145 issued 1998-01-13   Immunglobulins reactive with protegrins
    US1998000128345 1998-08-03  is a division of
    US1994000182483  1994-01-13   (granted)
         US5693486 issued 1997-12-02   DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
    US1994000243879 1994-05-17  is a continuation in part of
    US1994000182483  1994-01-13   (granted)
         US5693486 issued 1997-12-02   DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
    US1998000128345 1998-08-03  is a division of
    US1993000095769  1993-07-26   (granted)
         US5464823 issued 1995-11-07   Mammalian antibiotic peptides
    US1994000182483 1994-01-13  is a continuation in part of
    US1993000095769  1993-07-26   (granted)
         US5464823 issued 1995-11-07   Mammalian antibiotic peptides
    US1998000128345 1998-08-03  is a division of
    US1993000093926  1993-07-20   (abandoned)
    US1993000095769 1993-07-26  is a continuation in part of
    US1993000093926  1993-07-20   (abandoned)


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