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Title: US5821085: Nucleotide sequences of a T. pallidum rare outer membrane protein
[ Derwent Title ]


Country: US United States of America

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29 pages

 
Inventor: Blanco, David R.; Beverly Hills, CA
Miller, James N.; Northridge, CA
Lovett, Michael A.; Los Angeles, CA
Champion, Cheryl I.; Culver City, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1998-10-13 / 1997-04-23

Application Number: US1997000842199

IPC Code: Advanced: C07K 14/20; C07K 16/12; C12N 1/21; G01N 33/571; A61K 38/00; A61K 39/00;
Core: C07K 14/195; more...
IPC-7: C07H 21/04; C12N 1/21; C12N 15/00; C12N 15/63;

ECLA Code: C07K14/20; C07K16/12A10; G01N33/571;

U.S. Class: Current: 435/069.1; 435/252.3; 435/320.1; 536/023.7; 536/024.32; 536/024.33;
Original: 435/069.1; 435/172.3; 435/252.3; 435/320.1; 536/023.7; 536/024.32; 536/024.33; 935/008; 935/011; 935/066;

Field of Search: 435/69.1,172.3,252.3,320.1 536/23.7,24.32,24.33 935/008,11,66

Government Interest:     This work was supported by U.S. Government NIH grant AI 21352 and AI 29733.

Priority Number:
1997-04-23  US1997000842199
1994-08-17  US1994000292904
1994-06-07  US1994000255322
1994-01-06  US1994000178084

Abstract: Antigenic rare outer membrane proteins of Spirochaetaceae are obtained from organisms extracted from infected tissue by a novel process of isolation utilizing a discontinuous Ficoll gradient separation, release of outer membrane in a low isotonic and low pH buffer and identification of outer membrane by use of a lipid soluble dye. Four antigenic rare outer membrane proteins of T. pallidum subsp. pallidum useful in diagnosis and prophylaxis of syphilis are provided. Also provided is the amino acid sequence of a rare outer membrane protein of T. pailidum subsp. pallidum and the nucleotide sequence encoding it.

Attorney, Agent or Firm: Fish & Richardson P.C. ;

Primary / Asst. Examiners: Myers, Carl J.;

Maintenance Status: E2 Expired  Check current status

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Related Applications: Go to Result Set: 1 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1994000292904 1994-08-17       
US1994000255322 1994-06-07       
US1994000178084 1994-01-06       


       
Parent Case:     This is a divisional of application Ser. No. 08/292,904, filed Aug. 17, 1994, now abandoned, which is a continuation in part of Ser. No. 08/255,322, filed Jun. 7, 1994, now abandoned, which is a continuation in part of Ser. No. 08/178,084, filed Jan. 6, 1994, now abandoned.

Designated Country: AU CA EP JP MX 

Family: Show 7 known family members

First Claim:
Show all 11 claims
We claim:     1. An isolated nucleic acid fragment that encodes the protein of SEQ ID NO:2.

Background / Summary: Show background / summary

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U.S. References: Go to Result Set: No U.S. references   |  No patents reference this one   |   Backward references (0)

       
Foreign References: None

Other Abstract Info: CHEMABS 123(15)193035E CHEMABS 129(02)013218J DERABS C1995-254907

Other References:
  • Norris et al, Microbiological Reviews (1993) 57:750-779. (30 pages) Cited by 4 patents [ISI abstract]
  • Blanco et al, 1991, Molecular Microbiology 5(10) 2405-2415. (11 pages) [ISI abstract]


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