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 Title: |
US5824321:
Cloned leptospira outer membrane protein
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Haake, David A.; Culver City, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1998-10-20
/ 1997-07-01
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| Application Number: |
US1997000886863
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| IPC Code: |
Advanced:
C07K 14/20;
C07K 16/12;
C12N 1/21;
C12N 15/09;
C12N 15/31;
C12P 21/02;
C12P 21/08;
C12Q 1/68;
G01N 33/569;
G01N 33/577;
A61K 39/00;
C12R 1/19;
Core:
C07K 14/195;
more...
IPC-7:
A61K 39/002;
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| ECLA Code: |
C07K14/20;
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| U.S. Class: |
Current:
424/266.1;
424/265.1;
530/350;
530/820;
530/822;
Original:
424/266.1;
530/350;
530/820;
530/822;
424/265.1;
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| Field of Search: |
530/350,403,820,822
435/69.3,69.7,71.1,172.1
424/265.1,266.1,269.1
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| Government Interest: |
This invention was made with Government support by the Veteran's Administration Research Advisory Group and Grant Nos. Al-21352, Al-29733, and Al-12601 awarded by the National Institutes of Health. The Government has certain rights in the invention.
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| Priority Number: |
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| Abstract: |
An antigenic preparation is provided which contains a 63 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism. Also provided in the invention are polynucleotides encoding the protein and antibodies which bind the protein which are useful in the diagnosis of leptospirosis.
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| Attorney, Agent or Firm: |
Fish & Richardson P.C. ;
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| Primary / Asst. Examiners: |
Spector, Lorraine;
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| Maintenance Status: |
E2 Expired Check current status
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| INPADOC Legal Status: |
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 124(09)115445V
DERABS C1996-020532
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| Other References: |
Dunn et al., "Outer Surface Protein A (OspA) from the Lyme Disease Spirochete, Borrelia burgdorferi: High Level Expression and Purification of a Soluble Recombinant Form of OspA," Protein Expression and Purification, vol. 1, No. 2, (2pgs.).
Kida et al., "Immunological and Morphological Analysis of Sodium Dodecyl Sulfate Extract of Leptospira," Zbl. Bakt. HY6 I. ABT. Orig. A 236, pp. 328-335 (1976).
(8 pages)
Cited by 2 patents
Nicholson, Vivian and Prescott, John, "Outer Membrane proteins of three pathogenic Leptospira species," Veterinary Microbiology, 36, pp. 123-138 (1993).
(16 pages)
Cited by 7 patents
[ISI abstract]
Zuerner et al., "Characterization of outer member and secreted proteins of Leptospira interrogans serovar pomona," Microbial Pathogenesis, 10:pp. 311-322, (1991).
(12 pages)
Cited by 9 patents
[ISI abstract]
Brown et al., "Protein and Antigen Profiles of Prevalent Serovars of Leptospira interrogans," Infection and Immunity, vol. 59, No. 5, pp. 1772-1777 (May, 1991).
(6 pages)
Cited by 7 patents
[ISI abstract]
Haake et al., "Molecular Cloning and Sequence Analaysis of the Gene Encoding OmpL 1, a Transmembrane Outer Membrane Protein of Pathogenic Leptospira spp.," Journal of Bacteriology, vol. 175, No. 13, pp. 4225-4234, (Jul., 1993).
(10 pages)
Cited by 8 patents
[ISI abstract]
Nunes-Edwards et al. "Identification and Characterization of the Protein Antigens of Leptospira interrogans serovar hardjo," Infection and Immunity, vol. 48, No. 2, pp. 492-497, (May, 1985).
(6 pages)
Cited by 5 patents
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| Continuity Data: |
| Application Number | Filed | Notes |
|---|
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US2001000022461 | 2001-10-30 | is a
continuation of |
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US1998000175229
| 1998-10-20 |
(granted)
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US6309641 issued 2001-10-30 Antibodies to cloned Leptospira outer membrane protein and uses therefore
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US1998000175229 | 1998-10-20 | is a
division of |
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>US1997000886863<
| 1997-07-01 |
(granted)
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US5824321 issued 1998-10-20 Cloned leptospira outer membrane protein
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>US1997000886863< | 1997-07-01 | is a
division of |
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US1994000249013
| 1994-05-25 |
(granted)
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US5643754 issued 1997-07-01 Nucleic acids encoding a leptospira outer membrane protein
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