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 Title: |
US5837263:
Leptospira membrane proteins
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Haake, David A.; Culver City, CA
Shang, Ellen S.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1998-11-17
/ 1995-05-19
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| Application Number: |
US1995000444646
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| IPC Code: |
Advanced:
A61K 39/02;
A61K 39/395;
A61P 37/00;
C07K 14/20;
C07K 16/12;
C12N 1/21;
C12N 15/09;
C12P 21/02;
C12P 21/08;
G01N 33/53;
G01N 33/569;
A61K 39/00;
C12R 1/19;
Core:
C07K 14/195;
more...
IPC-7:
A61K 39/02;
C07K 1/00;
C12P 21/02;
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| ECLA Code: |
C07K14/20;
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| U.S. Class: |
Current:
424/234.1;
424/190.1;
435/069.1;
435/069.3;
435/071.1;
530/359;
Original:
424/234.1;
424/190.1;
435/069.1;
435/069.3;
435/071.1;
530/359;
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| Field of Search: |
435/69.1,69.3,71.1
530/359
424/190.1,234.1
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| Government Interest: |
This invention was made with Government support through funding from the Veterans' Administration Medical Research Funds, an NIH Multidisciplinary Training Grant in Microbial Pathogenesis 2-T32-AI0732-06, and awards from the United States Public Health Service under Grant Numbers AI 21352, AI 29733, and AI 12601.
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| Priority Number: |
| 1995-05-19 |
US1995000444646 |
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| Abstract: |
The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa. Also disclosed are the method for purifying these proteins from Leptospira, their nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, methods for producing antibodies to these proteins, the resulting antibodies. These proteins, their immunogenim. fragments, and antibodies against them, are useful for inducing an immune response to pathogenic Leptospira as well as providing a diagnostic target for leptospirosis.
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| Attorney, Agent or Firm: |
Fish & Richardson P.C. ;
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| Primary / Asst. Examiners: |
Housel, James C.; Swartz, Rodney P.
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| Maintenance Status: |
E2 Expired Check current status
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE AU CA EP JP
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| Family: |
Show 15 known family members
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First Claim:
Show all 12 claims |
We claim:
1. A purified protein possessing the amino acid sequence selected from the group consisting of: LipL1 of SEQ ID No. 3 or LipL2 of SEQ ID No. 6.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
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| Forward References: |
Show 2 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 126(06)073779R
DERABS C1997-011850
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| Other References: |
Cinco, M., et al., "Immunodominant antigens recognized by the human immune response to infection by organisms of the species Leptospira interrogans serogroup Australis", FEMS Microbiology Letters, 89:287 (1992).
(11 pages)
Cited by 4 patents
[ISI abstract]
Yang, N.-S., et al., "Gene Transfer via Particle Bombardment: Applications of the Accell Gene Gun", Gene Therapeutics: Methods and Applications of Direct Gene Transfer, Wolff, J. A. ed., Birkhauser, p. 193, USA (1994).
PCT based on U.S. patent application Ser. No. 08/040,747, "Cloned Leptospira Outer Membrane Protein" to Haake, D.A., et al., as filed.
Akins, D. R., et al., "Lipid Modification of the 17-Kilodalton Membrane Immunogen of Treponema pallidum Determines Macrophage Activation as well as Amphiphilicity", Infect. Immun., 61:1202 (1993).
(9 pages)
Cited by 8 patents
[ISI abstract]
Baril, C., et al., "Sizing of the Leptospira genome by pulsed-field agarose gel electrophoresis", FEMS Microbiology Letters, 71:95 (1990).
(5 pages)
Cited by 4 patents
Bolin, C. A., et al., "Effect of vaccination with a pentavalent leptospiral vaccine on Leptospira interrogans serovar hardjo type hardjo-bovis infection of pregnant cattle", Am. J. Vet. res., 50:161 (1989).
(5 pages)
Cited by 4 patents
Bolin, C. A., et al., "Effect of vaccination with a pentavalent leptospiral vaccine containing Leptospira interrogans serovar hardjo type hardjo-bovis on type hardjo-bovis infection of cattle", Am. J. Vet. Res., 50:2004 (1989).
(5 pages)
Cited by 3 patents
Bolin, C. A., "Effect of vaccination with a monovalent Leptospira interrogans serovar hardjo type hardjo-bovis vaccine in type hardjo-bovis infection of cattle", et al., Am. J. Vet. Res., 52:1639 (1991).
(5 pages)
Cited by 4 patents
[ISI abstract]
Brandt, et al., "Immunogenic Integral Membrane Proteins of Borrelia burgdorferi Are Lipoproteins", Infect. Immun., 58:983 (1990).
(9 pages)
Cited by 24 patents
Chamberlain, N. R., et al., "Major Integral Membrane Protein Immunogens of Treponema pallidum Are Proteolipids", Infect. Immun., 57:2872 (1989).
(6 pages)
Cited by 4 patents
Chamberlain, N. R., et al., "Acylation of the 47-Kilodalton Major Membrane Immunogen of Treponema pallidum Determines Its Hydrophobicity", Infect. Immun., 57:278 (1989).
Cunningham, et al., "Selective Release of the Treponema pallidum Outer Membrane and Associated Polypeptides with Triton X-114", J. Bacteriol., 170:5789 (1988).
(8 pages)
Cited by 7 patents
DNA Relatedness of Leptospiraceae Serovars (Prepublication Listing Subject to Revision), Emerging Bacterial and Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infections Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333 (Jun. 7, 1994).
Doherty, J. P., et al., Biol. Abstract, Immunology, 87(11):AB-477, Ref. No. 115457.
Farr. R. W., "Leptospirosis", State-Of-The-Art Clinical Article, Clinical Infectious Diseases, 21:1 (1995).
(6 pages)
Cited by 5 patents
[ISI abstract]
Haake, D. A., et al., "Changes in the surface of Leptospira interrogans Serovar grippotyphosa during In Vitro Cultivation", Infection & Immunity, (1991).
Haake, D. A., et al., "Molecular Cloning and Sequence Analysis of the Gene Encoding OmpL1, a Transmembrane Outer Membrane Protein of Pathogenic Leptospira spp.", J. Bacteriol, 175:4225 (1993).
(10 pages)
Cited by 8 patents
[ISI abstract]
Hayashi, S., et al., "Lipoproteins in Bacteria", J. Bioenerg. Biomembr., 22:451 (1990).
(21 pages)
Cited by 10 patents
Miyamoto, M., et al., "Molecular cloning and Sequence Analysis of Antigen Gene tdpAof Treponema denticola", Infect. Immun., 59:1941 (1991).
(7 pages)
Cited by 4 patents
[ISI abstract]
Penn, C. W., et al., "Genetic approaches to cell biology and metabolism of spirochetes", Res. Microbiol., 143:605 (1992).
(9 pages)
Cited by 4 patents
[ISI abstract]
Ramadass, P., et al., "Genetic Characterization of Pathogenic Leptospira Species by DNA Hybridization", Int'l. J. of Systematic Bacteriol., 42:215 (1992).
(5 pages)
Cited by 4 patents
[ISI abstract]
Richaud, C., et al., "Cloning of gens required for amino acid biosynthesis from Leptospira interrogans serovar icterohaemorrhagiae", J. of Gen. Microbiology, 136:651 (1990).
(6 pages)
Cited by 2 patents
Sambrook, J., et al., Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory, Cold Springs Harbor, NY (1989) Table of Contents xi-xxxviii.
Stamm, et al., "Changes in the Cell Surface Properties of Treponema pallidum That Occur during In Vitro Incubation of Freshly Extracted Organisms", Infect. Immun., 55:2255 (1987).
(7 pages)
Cited by 5 patents
Thiermann, et al., "Leptospirosis: Current developments and trends", J. Am. Vet. Med. Assoc., 184:722 (1984).
(4 pages)
Cited by 5 patents
Thiermann, A. B., et al., "Improved Techniques for the Isolation of Leptospires from Swine Abortion Cases", Ann. Proc. Amer. Assn. Veterinary Laboratoty Diagnosticians, 27:233 (1984).
Thomas, W., et al., "Molecular Cloning, Expression, and DNA Sequence Analysis of the Gene That Enclodes the 16-Kilodalton Outer Membrane Lipoprotein of Serpulina hyodysenteriae", Infec. Immun., 61:1136 (1993).
(5 pages)
Cited by 3 patents
[ISI abstract]
Van Eys, G. J. J. M., et al., "DNA Hybridization with Hardjobovis-specific Recombinant Probes as a Method for Type Discrimination of Leptospira interrogans Serovar hardjo", J. of Gen. Microbiology, 134:567 (1988).
(8 pages)
Cited by 5 patents
von Heijne, G., "The structure of signal peptides from bacterial lipoproteins", Protein Engineering, 2:531 (1989).
(4 pages)
Cited by 4 patents
Yasuda, P. H., et al., "Deoxyribonucleic Acid Relatedness between Serogroups and Serovars in the Family of Leptospiraceae with Proposals for Seven New LeptospiraSpecies", Int'l J. Systematic Bacteriology, 37:407 (1987).
(9 pages)
Cited by 6 patents
Zuerner, et al., "Characterization of outer membrane and secreted proteins of Leptospira interrogans serovar pomana", Microbial. Pathogenesis, 10:311 (1991).
(12 pages)
Cited by 9 patents
[ISI abstract]
Knudsen, K.A. Anal. Bioch., 147:285-288 (1985).
(4 pages)
Cited by 12 patents
Gritton, X. et al. Vt. Microbiol., 32:293-303 (1992).
Brown, J.A. et al. Infect. Immun., 59:1772-1777 (1991).
(6 pages)
Cited by 7 patents
[ISI abstract]
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| Continuity Data: |
| Application Number | Filed | Notes |
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US2001000992807 | 2001-11-13 | is a
continuation of |
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US1998000193441
| 1998-11-17 |
(pending)
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US1998000193441 | 1998-11-17 | is a
division of |
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>US1995000444646<
| 1995-05-19 |
(granted)
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US5837263 issued 1998-11-17 Leptospira membrane proteins
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