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Title: US5843711: Diphtheria toxin receptor-binding region
[ Derwent Title ]

Country: US United States of America

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23 pages

 
Inventor: Collier, R. John; Wellesley Hills, MA
Eisenberg, David; Los Angeles, CA
Fu, Haian; Allston, MA
Choe, Seunghyon; Reseda, CA

Assignee: The Regents of the University of California, Oakland, CA
The President and Fellows of Harvard College, Cambridge, MA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1998-12-01 / 1995-11-02

Application Number: US1995000552248
IPC Code: Advanced: C07K 14/34; A61K 39/00;
Core: C07K 14/195; more...
IPC-7: C12N 15/00;

ECLA Code: C07K14/34;

U.S. Class: Current: 435/069.1; 435/069.3; 435/252.3; 435/320.1; 514/002; 536/022.1; 536/023.1; 536/023.2; 536/023.4; 536/023.7;
Original: 435/069.1; 435/069.3; 435/252.3; 435/320.1; 514/002; 536/022.1; 536/023.1; 536/023.2; 536/023.4; 536/023.7;

Field of Search: 435/69.1,69.3,240.2,252.3,320.1 514/002 536/22.1,23.1,23.2,23.4,23.7

Government Interest:     This invention was made with Government support under GM31299 and GM39558 awarded by the National Institute of Health, and under AI-22021 and AI-22848 awarded by the National Institute of Arthritis and Infectious Diseases. The government has certain rights in the invention.

Priority Number:
1995-11-02  US1995000552248
1993-09-09  US1993000119316
1992-05-06  US1992000881394

Abstract: The invention features a polypeptide consisting of amino acids 379-535 of diphtheria toxin, and portions thereof. This region, shown by X-ray crystallographic analysis to comprise the receptor binding domain of diphtheria toxin, is used as an immunogen and clinical therapeutic against diphtheria.

Attorney, Agent or Firm: Fish & Richardson, P.C. ;

Primary / Asst. Examiners: Wax, Robert A.; Longton, Enrique D.
INPADOC Legal Status: None          Buy Now: Family Legal Status Report

       
Related Applications:
Application Number Filed Patent Pub. Date  Title
US1993000119316 1993-09-09       
US1992000881394 1992-05-06       


       
Parent Case:     This is a continuation of application Ser. No. 08/119,316, filed Sep. 9, 1993 now abandoned; which in turn is a continuation of application Ser. No. 07/881,394, filed May 6, 1992, now abandoned.

Designated Country: BB BG BR CA CZ HU KP KR LK MG MN MW NO NZ PL RO RU SD SK UA  BE CH FR GB IE IT LI LU MC NL PT SE 

Family: Show 12 known family members
First Claim:
Show all 15 claims		 What is claimed is:     1. A DNA encoding a polypeptide consisting of:
a) amino acids 379-535;
b) amino acids 380-535;
c) amino acids 381-535;
d) amino acids 382-535;
e) amino acids 383-535;
f) amino acids 384-535;
g) amino acids 385-535;
h) amino acids 386-535;
i) amino acids 496-512;
j) amino acids 379-512;
k) amino acids 380-512;
l) amino acids 381-512;
m) amino acids 382-512;
n) amino acids 383-512;
o) amino acids 384-512;
p) amino acids 385-512;
q) amino acids 386-512;
r) amino acids 496-535; or
s) amino acids 496-524 (all of FIG. 5 (SEQ ID NO: 1)), wherein said DNA does not encode an amino acid sequence corresponding to amino acids 291 to 378 of FIG. 5 (SEQ ID NO:1) immediately adjacent to the amino terminal end of said polypeptide and said polypeptide is capable of binding a diphtheria toxin sensitive cell.

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Forward References: Show 1 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (1)   |   Backward references (2)   |   Citation Link

Buy
PDF		 Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 4pp US4709017  1987-11 Collier et al.  President and Fellows of Harvard College Modified toxic vaccines
Buy PDF- 11pp US4950740  1990-08 Greenfield et al.  Cetus Corporation Recombinant diphtheria vaccines
       
Foreign References:
Buy
PDF		 Publication Date IPC Code Assignee   Title
  EP1989A-0332174 1989-09       


Other Abstract Info: CHEMABS 120(13)156463K DERABS C1993-368278

Other References:
  • Haynes (1993) Science. vol. 260, pp. 1279-1286. (8 pages) Cited by 156 patents [ISI abstract]
  • Osterhaus et al. (1994) J. Infectious Diseases. vol. 170 (Suppl. 1):S42-55. (14 pages) [ISI abstract]
  • Orkin et al. (Dec. 1995) "Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy", Issued by the National Institutes of Health.
  • Stone "Biology approaches TeraPop Era" Science vol. 256, pp. 440-442 (1992). (3 pages) Cited by 2 patents [ISI abstract]
  • Rolf et al. "Localization of the Diptheria . . . " JBC 265:13 pp. 7331-7337 May 5, 1990. (7 pages) Cited by 2 patents
  • Anderson, P., 1983, Infection and Immunity, 39:233-238. (6 pages) Cited by 24 patents
  • Anderson, P., et al., 1985, J Clin Invest, 76:52-59. (8 pages) Cited by 10 patents
  • Arnon, R., 1986, Trends Biochem, 11:521-524. (4 pages) Cited by 2 patents
  • Boquet, P., et al., 1981k Eur J Biochem, 121:93-98.
  • Eskola, J., et al., 1985, The Lancet, 1:1184-1186. (3 pages) Cited by 3 patents
  • Giannini, G., et al., 1984, Nucleic Acids Research, 12:4063-4069. (7 pages) Cited by 11 patents
  • Greenfield, L., et al., 1987, Science, 238:536-539. (4 pages) Cited by 33 patents
  • Greenfield, L., et al., 1983, PNAS, 80:6853-6857.
  • McGill, S., et al., 1989, The EMBO J, 8:2843-2848. (6 pages) Cited by 2 patents
  • Rolf, J.M. et al., Abstracts of the 91st Meeting of the Am Soc for Microbiol, 91:75, #B-296. (1991).
  • Rolf, J.M., et aL., 1991, 75th Annuan Meeting, FASEB J. 5:A821, #2619. (1 pages) Cited by 2 patents [ISI abstract]
  • Tang, D., et al., 1992, Nature, 356:152-154. (3 pages) Cited by 123 patents [ISI abstract]
  • Uchida, T., et al., 1971, Nature New Biology, 233:8-11.
  • Wen, Z., et al., 1991, The J of Biol Chem, 19:12289-12293. (5 pages) Cited by 4 patents [ISI abstract]


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