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 Title: |
US5846740:
Methods and kits useful for detecting autoantibody to glutamic acid decarboxylase
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Tobin, Allan J.; Los Angeles, CA
Erlander, Mark G.; Tarzana, CA
Kaufman, Daniel L.; Santa Monica, CA
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| Assignee: |
The Regents of The University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1998-12-08
/ 1995-09-22
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| Application Number: |
US1995000484530
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| IPC Code: |
Advanced:
A61P 37/06;
C07K 16/40;
C12N 5/20;
C12N 9/88;
G01N 33/564;
G01N 33/573;
A61K 38/00;
A61K 39/00;
Core:
A61P 37/00;
more...
IPC-7:
A61K 38/00;
C07K 1/00;
G01N 33/53;
G01N 33/573;
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| ECLA Code: |
C07K16/40; C12N9/88; G01N33/564; G01N33/573; K61K38/00; K61K39/00; M12N203/00; M12N207/00; M12N215/00; M12Q220/114F35; M12Q220/120; S01N800/04A; S01N800/24;
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| U.S. Class: |
Current:
435/007.4;
435/007.92;
435/975;
530/300;
530/350;
Original:
435/007.4;
435/007.92;
435/975;
530/300;
530/350;
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| Field of Search: |
435/7.4,7.92,975
530/300,350
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| Government Interest: |
The present invention was supported by Grant NS22256 from the National Institutes of Health. The United States Government has certain rights in this invention.
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| Priority Number: |
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| Abstract: |
Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.
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| Attorney, Agent or Firm: |
Trecartin, Richard F. ;
Kresnak, Mark T.Flehr Hohbach Test Albritton and Herbert LLP ;
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| Primary / Asst. Examiners: |
Hutzell, Paula K.; Navarro, Mark
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Parent Case: |
This is a divisional of application Ser. No. 08/123,859 filed Sep. 17, 1993, now U.S. Pat. No. 5,674,978, which is a continuation-in-part of application Ser. No. 07/716,909 fled Jun. 18, 1991, abandoned, which is a continuation-in-part of application Ser. No. 07/586,536 filed Sep. 21, 1990.
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| Designated Country: |
BE CH FR GB IT LI LU MC NL PT SE IE NO
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| Family: |
Show 68 known family members
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First Claim:
Show all 8 claims |
We claim:
1. A method for detecting autoantibody to glutamic acid decarboxylase (GAD) in a patient specimen which comprises contacting the specimen with a polypeptide consisting of an amino acid sequence selected from the group consisting of:
- QKFTGGIGNKLCALLYGD (SEQ ID NO:60);
- LLYGDAEKPAESGGSQPPRA (SEQ ID NO:17);
- KPCSCSKVDVNYAFLHATDL (SEQ ID NO:06);
- LAFLQDVMNILLQYVVKSFDRS (SEQ ID NO:21);
- EEILMHCQTTLKYAIKTGHP (SEQ ID NO:24);
- AFTSEHSHFSLKKGAAALGI (SEQ ID NO:32);
- AALGIGTDSVILIKCDERGK (SEQ ID NO:33);
- DERGKMIPSDLERRILEAKQ (SEQ ID NO:34);
- LEAKQKGFVPFLVSATAGTT (SEQ ID NO:35);
- GLLMSRKHKWKLSGVERANS (SEQ ID NO:38);
- VPLQCSALLVREEGLMQNCNQ (SEQ ID NO:40);
- KHYDLSYDTGDKALQCGRHV (SEQ ID NO:42);
- EYLYNIIKNREGYEMVFDGK (SEQ ID NO:09);
- IPPSLRTLEDNEERMSRLSK (SEQ ID NO:47);
- SRLSKVAPVIKARMMEYGTT (SEQ ID NO:11);
- EYGTTMVSYQPLGDKVNFFR (SEQ ID NO:12);
- VNFFRMVISNPAATHQDIDF (SEQ ID NO:50);
- ATHQDIDFLIEEIERLGQDL (SEQ ID NO:13);
- amino acids 224-398 of SEQ ID NO:57; and
- amino acids 398-585 of SEQ ID NO:57;
and determining whether autoantibody binds to the polypeptide.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 4 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 117(23)227775Q
CHEMABS 118(23)225673B
CHEMABS 123(03)028599J
CHEMABS 127(23)315578Q
DERABS C1992-150489
DERABS C1992-425701
DERABS C1995-131360
DERABS C2000-095930
DERABS C2000-500251
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| Other References: |
Baekkeskov et al., "Revelation of Specificity of 64K Autoantibodies in IDDM Serums by High-Resolution 2-D Gel Electrophoresis", Diabetes (1989), 38:1133-1141.
(9 pages)
Cited by 9 patents
Wraith et al., "Antigen Recognition in Autoimmune Encephalomyelitis and the Potential for Peptide-Mediated Immunotherapy", Cell (1989), 59:247-255.
(9 pages)
Cited by 56 patents
Gerling et al., "Effect of Coxsackievirus B4 Infection in Mice on Expression of 64,000-M Autoantigen and Glucose Sensitivity of Islets Before Development of. . .", Diabetes (1988), 37:1419-1425.
(7 pages)
Cited by 6 patents
Dyrberg, "Molecular Mimicry and Diabetes", Current Topics in Microbiology & Immun. (1989), 145:118-125.
Julien et al., "Rat Brain Glutamic Acid Decarboxylase Sequence Deduced from a Cloned cDNA", J. of Neurochemistry (1990), 54:703-705.
(3 pages)
Cited by 16 patents
Schwimmbeck et al., "Molecular Mimicry and Myasthenia Gravis", J. Clin. Invest. (1989), 84:1174-1180.
(7 pages)
Cited by 7 patents
Todd et al., "A Molecular Basis for Genetic Susceptibility to Insulin-Dependent Diabetes Mellitus", TIG (1988), 4:129-134.
(6 pages)
Cited by 7 patents
Chang and Gottlieb, "Characterization of the Proteins Purified with Monoclonal Antibodies to Glutamic Acid Decarboxylase", J. of Neuroscience (1988), 6:2123-2130.
(8 pages)
Cited by 14 patents
Legay et al., "Evidence for Two Distinct Forms of Native Glutamic Acid Decarboxylase in Rat Brain Soluble Extract: An Immunoblotting Study", J. of Neurochemistry (1987), 48:1022-1026.
(5 pages)
Cited by 9 patents
Julien et al., "Molecular Cloning, Expression and in situ Hybridization of Rat Brain Glutamic Acid Decarboxylase Messenger RNA", Neuroscience Letters (1987), 73:173-180.
(8 pages)
Cited by 9 patents
Baekkeskov et al., "Identification of the 64K Autoantigen in Insulin-Dependent Diabetes as the GABA-Synthesizing Enzyme Glutamic Acid Decarboxylase", Nature (1990), 347:151-156.
(6 pages)
Cited by 44 patents
Michelesen et al., "Cloning, Characterization, and Autoimmune Recognition of Rat Islet Glutamic Acid Decarboxlase in Insulin-Dependent Diabetes Mellitus", P.N.A.S. USA (1991), 88:8754-8758.
(5 pages)
Cited by 13 patents
[ISI abstract]
Solimena et al., "Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiffman Syndrom", N. Engl. J. Med. (1990) 322:1555-1560.
(6 pages)
Cited by 13 patents
Kobayashi et al., "Glutamic Acid Decarboxylase cDNA: Nucleotide Sequence Encoding an Enzymatically Active Fusion Protein", J. of Neurosience (1987), 9:2768-2772.
(5 pages)
Cited by 10 patents
Atkinson and Maclaren, "What Causes Diabetes?", Sci. Amer. (1990), 62-71.
Cited by 12 patents
Baekkeskov et al., "Autoantibodies in Newly Diagnosed Diabetic Children Immunoprecipitate Human Pancreatic Islet Cell proteins", Nature (1982), 298:167-169.
(3 pages)
Cited by 32 patents
Baekkeskov et al., "Antibodies to a 64,000 M.tau. Human Inslet Cell Antigen Precede the Clinical Onset of Insulin-Dependent Diabetes", J. Clin. Invest. (1987), 79:926-934.
(9 pages)
Cited by 23 patents
Christie et al., "Cellular and Subcellular Localization of an M.tau. 64,000 Protein Autoantigen in Insulin-Dependent Diabetes", J. Bio. Chem. (1990), 265:376-381.
(6 pages)
Cited by 14 patents
Atkinson et al., "64,000 M.tau. Autoantibodies as Predictors of Insulin-Dependent Diabetes", The Lancet (1990), 335:1357-1360.
(4 pages)
Cited by 19 patents
Ziegler et al., "Predicting Type 1 Diabetes", Diabetes Care (1990), 13:762-775.
(14 pages)
Cited by 11 patents
Kaufman et al., "Brain Glutamate Decarboxylase Cloned in .lambda.gt-11: Fusion Protein Produces .tau.-Aminobutyric Acid", Science (1986), 232:1138-1140.
(3 pages)
Cited by 16 patents
Wyborski et al., "Characterization of a cDNA Coding for Rat Glutamic Acid Decarboxylase", Molecular Brain Research (1990), 8:193-198.
(6 pages)
Cited by 10 patents
Katarova et al., "Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the Mouse", European J. of Neuroscience (1990), 2:190-202.
(13 pages)
Cited by 10 patents
Persson et al., "Expression of the Neurotransmitter-Synthesizing Enzyme Glutamic Acid Decarboxylase in Male Germ Cells", Molecular and Cellular Biology (1990), 10:4701-4711.
(11 pages)
Cited by 10 patents
Salgaller et al (Cancer Immunol. Immunother. vol. 39 1994 pp. 105-116).
(12 pages)
Cited by 60 patents
[ISI abstract]
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