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 Title: |
US5853737:
Method for inducing a CD1-restricted immune response
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Modlin, Robert L.; Sherman Oaks, CA
Sieling, Peter A.; Malibu, CA
Brenner, Michael B.; Brookline, MA
Porcelli, Steven A.; Brighton, MA
Brennan, Patrick J.; Fort Collins, CO
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| Assignee: |
Brigham and Women's Hospital, Boston, MA
University of California, Los Angeles, Los Angeles, CA
Colorado State University Research Foundation, Fort Collins, CO
other patents from BRIGHAM AND WOMEN'S HOSPITAL (75590) (approx. 328)
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| Published / Filed: |
1998-12-29
/ 1994-10-13
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| Application Number: |
US1994000322979
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| IPC Code: |
Advanced:
A61K 39/00;
A61K 39/04;
C07K 14/74;
C07K 16/28;
C12P 19/04;
Core:
C07K 14/435;
C07K 16/18;
C12P 19/00;
more...
IPC-7:
A61K 31/185;
A61K 31/70;
A61K 39/04;
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| ECLA Code: |
A61K39/00; A61K39/04; C07K14/705B28; C07K16/28A; C12P19/04;
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| U.S. Class: |
Current:
424/248.1;
424/185.1;
424/278.1;
424/279.1;
514/023;
514/054;
530/359;
Original:
424/248.1;
424/185.1;
424/278.1;
424/279.1;
530/359;
514/023;
514/054;
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| Field of Search: |
424/185.1,248.1,278.1,279.1
530/350,395,868,359
514/023,54
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| Government Interest: |
GOVERNMENT SUPPORT
This invention was supported, in whole or in part, by grants Nos. 5 KO8 AI40135, 5 R37 AI28973, 5 R37, AI18357, AI05074, 5 ROI AI22553, 5 ROI AI136069, 5 ROI AR40312, CA09120, and 5 KO8 AR01937 from the National Institute of Health. The Government has certain rights in the invention.
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| Priority Number: |
| 1994-10-13 |
US1994000322979 |
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| Abstract: |
The present invention is based on the observation that CD1 functions to present foreign and autoimmune antigens to a select subpopulation of T-cells. Based on this observation, the present invention provides methods for detecting the presence of a CD1-presented antigen in a sample, methods for purifying CD1-presented antigens, vaccines containing CD1-presented antigens, methods of blocking CD1 antigen presentation, methods of identifying and/or isolating CD1 blocking agents, methods of inducing CD1 expression, and T-cell lines for use in the methods disclosed herein. The CD1-presented antigens of the invention, unlike MHC-presented antigens, are non-polypeptide hydrophobic antigens. In particular, a CD1-presented antigen isolated from several mycobacterial species is a lipoarabinomannan (LAM).
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| Attorney, Agent or Firm: |
Hamilton, Brook, Smith & Reynolds, P.C. ;
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| Primary / Asst. Examiners: |
Cunningham, Thomas M.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
RELATED APPLICATIONS
This application is a continuation-in-part application of PCT application PCT/US94/06991, filed Jun. 21, 1994, which is a continuation-in-part application of U.S. Ser. No. 08/080,072, filed Jun. 21, 1993 now abandoned, which is a continuation-in-part application of U.S. Ser. No. 07/989,790, filed Dec. 10, 1992, now abandoned.
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| Designated Country: |
AL AM AP BB BG BR BY CN CZ EE FI GE HU IS KE KG KP KR KZ LK LR LT LV AT BE CH DE DK ES FR GB GR IE IT LI LU
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| Family: |
Show 30 known family members
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First Claim:
Show all 60 claims |
What is claimed is:
1. A method for inducing a CD1-restricted immune response, wherein the method comprises administration to the mammal of an effective immune-enhancing amount of an isolated CD1-presented lipoarabinomannan antigen which can induce the CD1-restricted immune response thereby enhancing the immunity of the mammal.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
Show description
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| Forward References: |
Show 4 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 122(11)131025X
CHEMABS 125(03)031927M
CHEMABS 127(25)345329B
DERABS C95-051745
DERABS C96-222130
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| Other References: |
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Sieling, P., Porcelli, S., Chatterjee, D., Brennan, P, Brenner, M., Rea, T., and Modlin, R., "CD1-Restricted αβ TCR T-Cells Recognize Non-Peptide Ligands from Microbial Pathogens," Abstract 90, (from The Journal of Investigative Dermatology, vol. 104, No. 4 (Apr., 1995), p. 569.
(1 pages)
Cited by 4 patents
[ISI abstract]
Beckman, E.M., Porcelli, S.A., Morita, C.T., Behar, S.M., Furlong, S.T., and Brenner, M.B., "Recognition of a Lipid Antigen by CD1-Restricted αβ+ T Cells," Letters to Nature, vol. 372, No. 6507, pp. 691-694 (Dec. 15, 1994).
(4 pages)
Cited by 3 patents
[ISI abstract]
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(4 pages)
Cited by 4 patents
[ISI abstract]
Prinzis, S., Chatterjee, D., and Brennan, P.J., "Structure and Antigenicity of Lipoarabinomannan from Mycobacterium bovis BCG," Journal of General Microbiology, vol. 139, No. 11, pp. 2649-2658 (Nov. 1993).
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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(4 pages)
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[ISI abstract]
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(4 pages)
Cited by 4 patents
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[ISI abstract]
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(10 pages)
Cited by 9 patents
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[ISI abstract]
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(4 pages)
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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| Continuity Data: |
| Application Number | Filed | Notes |
|---|
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US1994000322979 | 1994-10-13 | is a
related to the prior publication |
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US20020009465A1 issued 2002-01-24 Presentation of hydrophobic antigens to T-cells by CD1 molecules
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>US1994000322979< | | is a
continuation in part of |
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WO1994US0006991
| 1994-06-21 |
(pending)
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WO9500163A1 issued 1995-01-05 METHODS OF ISOLATING CD1-PRESENTED ANTIGENS, VACCINES COMPRISING CD1-PRESENTED ANTIGENS, AND CELL LINES FOR USE IN SAID METHODS
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US2001000861963 | | is a
division of |
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US1995000501600
| 1995-07-12 |
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US6238676 issued 2001-05-29 Presentation of hydrophobic antigens to T-cells by CD1 molecules
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US1995000501600 | | is a
continuation in part of |
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US1994000322980
| 1994-10-13 |
|
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US5679347 issued 1997-10-21 Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
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US1994000322980 | | is a
continuation of |
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>US1994000322979<
| 1994-10-13 |
|
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US5853737 issued 1998-12-29 Method for inducing a CD1-restricted immune response
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PCT/US94/06991 | | is a
continuation in part of |
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US1993000080072
| 1993-06-21 |
(abandoned)
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US1993000080072 | | is a
continuation in part of |
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US1992000989790
| 1992-12-10 |
(abandoned)
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