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Title: US5854396: Protein, DNA coding for same and method of producing the protein
[ Derwent Title ]

Country: US United States of America

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13 pages

 
Inventor: Shimomura, Takeshi; Kanagawa, Japan
Kawaguchi, Toshiya; Kanagawa, Japan
Kitamura, Naomi; Kanagawa, Japan

Assignee: Mitsubishi Chemical Corporation, Tokyo, Japan
other patents from MITSUBISHI CHEMICAL CORPORATION (709856) (approx. 799)
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Published / Filed: 1998-12-29 / 1997-11-19

Application Number: US1997000974196
IPC Code: Advanced: C07K 14/81; C12N 15/15;
Core: more...
IPC-7: C07K 1/00; C12N 15/15; C12N 15/79;

ECLA Code: C07K14/81B1A;

U.S. Class: Current: 530/350; 435/069.1; 435/255.3; 435/320.1; 536/023.7;
Original: 530/350; 435/691; 435/252.3; 435/320.1; 536/023.7; 935/011; 935/032; 935/070;

Field of Search: 530/350 536/23.2 435/69.1,252.3,320.1

Priority Number:
1995-07-24  JP1995000187134

Abstract: A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 30,000 daltons) and partial amino acid sequence were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.

Attorney, Agent or Firm: Sughrue, Mion, Zinn, Macpeak & Seas, PLLC ;

Primary / Asst. Examiners: Wax, Robert A.; Moore, William
INPADOC Legal Status: None          Buy Now: Family Legal Status Report

       
Related Applications:
Application Number Filed Patent Pub. Date  Title
US1996000685660 1996-07-24    1998-03-24  Protein, DNA coding for same and method of producing the protein


       
Parent Case:     This is a Divisional of patent application Ser. No. 08/685,660, filed Jul. 24, 1996, now U.S. Pat. No. 5,731,412.

Designated Country: DE FR GB 

Family: Show 9 known family members
First Claim:
Show all 3 claims		 What is claimed is:     1. A substantially pure protein having the following physico-chemical properties:
  • (1) a molecular weight of about 30,000 daltons, as determined by SDS-polyacrylamide gel electrophoresis;
  • (2) inhibits hepatocyte growth factor activator protease activity; and
  • (3) the amino acid sequences set forth in SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3.
    •


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Forward References: Show 6 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (6)   |   Backward references (2)   |   Citation Link

Buy
PDF		 Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 20pp US5466593  1995-11 Shimomura et al.  Mitsubishi Kasei Corporation Hepatocyte growth factor activating protease and gene encoding the protease
Buy PDF- 13pp US5731412  1998-03 Shimomura et al.  Mitsubishi Chemical Corporation Protein, DNA coding for same and method of producing the protein
       
Foreign References: None

Other Abstract Info: CHEMABS 126(16)207827R DERABS C97-134770

Other References:
  • Neldini et al., EMBO J., 11:4825-4833 (1992).
  • Ponte et al, Nature, 331;525-527 (1988). (3 pages) Cited by 102 patents
  • Shimomura et al, Eur. J. Biochem, 229:257-261 (1995). (5 pages) Cited by 4 patents [ISI abstract]
  • Hillier et al, "The WashU-Merck EST Project", Accession No. R74593 (Seq. Ref. No. HS593137) (1995).
  • Hillier et al, "The WashU-Merck EST Project", Unpublished Data Entry No. H94519 (1995).
  • Hillier et al, "The WashU-Merck EST Project", Unpublished Data Entry No. W94849 (1995).
  • Hillier et al, "The WashU-Merck EST Project", Unpublished Data Entry No. N57450 (1995).
  • Hillier et al, "The WashU-Merck EST Project", Accession No. R35464 (Seq. Ref. No. HS46499) (1995).
  • Hillier et al, "The WashU-Merck EST Project", Accession No. H39798 (Seq. Ref. No. HS798277) (1996).
  • Miyazawa et al, Journal of Biological Chemistry, 268(14):10024-10028 (1993). (5 pages) Cited by 8 patents [ISI abstract]
  • Miyazawa et al, Journal of Biological Chemistry, 271(7):3615-3618 (1996). (4 pages) Cited by 4 patents [ISI abstract]


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