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 Title: |
US5866682:
Conopeptides AuIA, AuIB and AuIC
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
McIntosh, J. Michael; Salt Lake City, UT
Cartier, G. Edward; Salt Lake City, UT
Yoshikami, Doju; Salt Lake City, UT
Luo, Siqin; Salt Lake City, UT
Olivera, Baldomero M.; Salt Lake City, UT
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| Assignee: |
University of Utah Research Foundation, Salt Lake City, UT
other patents from UNIVERSITY OF UTAH RESEARCH FOUNDATION (600050) (approx. 286)
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| Published / Filed: |
1999-02-02
/ 1997-05-15
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| Application Number: |
US1997000857068
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| IPC Code: |
Advanced:
C07K 7/08;
C07K 14/435;
A61K 38/00;
Core:
C07K 7/00;
more...
IPC-7:
A61K 38/00;
A61K 38/04;
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| ECLA Code: |
C07K7/08A; C07K14/435A;
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| U.S. Class: |
Current:
530/326;
530/300;
530/327;
530/857;
Original:
530/326;
530/300;
530/327;
530/857;
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| Field of Search: |
530/326,300,327,857
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| Government Interest: |
This invention was made with Government support under Grant Nos. GM48677 and MH53631 awarded by the National Institutes of Health, Bethesda, M. The United States Government has certain rights in the invention.
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| Priority Number: |
| 1997-05-15 |
US1997000857068 |
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| Abstract: |
This invention relates to relatively short peptides about 14-17 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include two cyclizing disulfide linkages. More specifically, the present invention is directed to conopeptides having the general formula: Gly-Cys-Cys-Ser-Tyr-Xaa1 -Xaa1 -Cys-Phe-Ala-Thr-Asn-Xaa2 -Xaa3 -Xaa4 -Cys (SEQ ID NO: 1), wherein Xaa1 is Pro or Hyp (trans-4-hydroxy-Pro), Xaa2 is Ser, Pro or Hyp, Xaa3 is Gly or Asp and Xaa4 is a Tyr or des- Xaa4. The disulfide bridges are between the first and third between the second fourth cysteine residues. The C-terminal end is preferably amidated. The invention further relates to the specific peptides AuIA: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Ser-Asp-Tyr-Cys (SEQ ID NO:2); AuIB: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Pro-Asp-Cys (SEQ ID NO:3); and AuIC: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Ser-Gly-Tyr-Cys (SEQ ID NO:4). The invention also includes pharmaceutically acceptable salts of the conopeptides.
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| Attorney, Agent or Firm: |
Rothwell, Figg, Ernst & Kurz, P.C. ;
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| Primary / Asst. Examiners: |
Loring, Susan A.;
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EA EE EP ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK
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| Family: |
Show 3 known family members
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First Claim:
Show all 12 claims |
What is claimed is:
1. A substantially pure conopeptide having the general formula: Gly-Cys-Cys-Ser-Tyr-Xaa1 -Xaa1 -Cys-Phe-Ala-Thr-Asn-Xaa2 -Xaa3 -Xaa4 -Cys (SEQ ID NO:1), wherein Xaa1 is Pro or Hyp, Xaa2 is Ser, Pro or Hyp, Xaa3 is Gly or Asp and Xaa4 is a Tyr or des-Xaa4.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 4 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 130(03)021651F
DERABS C1999-059683
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| Other References: |
Cruz, L.J. et al., "Conus Peptides: Phylogenetic Range of Biological Activity," Biol. Bull., 183:159-164 (Aug., 1992).
(6 pages)
Cited by 2 patents
[ISI abstract]
International Search Report dated Jul. 30, 1998.
Olivera, B.M. et al. (1985). "Peptide Neurotoxins from Fish-Hunting Cone Snails." Science 230:1338-1343.
(6 pages)
Cited by 25 patents
Olivera, B.M. et al. (1990). "Diversity of Conus Neuropeptides." Science 249:257-263.
(7 pages)
Cited by 36 patents
Ramilo, C.A. et al. (1992). "Novel α-and ω-Conotoxins from Conus striatus Venom." Biochemistry 31:9919-9926.
(8 pages)
Cited by 5 patents
[ISI abstract]
Cartier, G.E. et al. (1996). "A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors." J. Biol. Chem. 271:7522-7528.
(7 pages)
Cited by 4 patents
[ISI abstract]
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