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Title: US5874471: Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection
[ Derwent Title ]


Country: US United States of America

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13 pages

 
Inventor: Waugh, William Howard; Greenville, NC 27858

Assignee: None

Published / Filed: 1999-02-23 / 1997-10-30

Application Number: US1997000961639

IPC Code: Advanced: A61K 31/198; A61K 33/06; A61K 33/12;
Core: A61K 31/185; more...
IPC-7: A61K 31/195;

ECLA Code: A61K31/198; A61K33/06+M; A61K33/12+M;

U.S. Class: Current: 514/563;
Original: 514/563;

Field of Search: 514/561,563

Priority Number:
1997-10-30  US1997000961639

Abstract: This invention is a novel method in orthomolecular health to sustain favorable amounts of L-arginine efficiently within the human body for preservation of good health and amelioration of various disease states. The method provides administration of sizable amounts of L-citrulline as precursor substance for bioconversion to L-arginine in order to maintain greater blood plasma concentrations of L-arginine as potential substrate for various metabolic functions. The method is useful to increase the availability of substrate for nitric oxide production by constitutive nitric oxide synthases. Embodiments include uses of exogenous L-citrulline for more vasoprotection in sickle cell disease and atherosclerosis, more stability in circulating platelets, more relaxative smooth muscle tone during pregnancy and in achalasia, greater defense against angiostenosis after angioplasty, greater defense against oxidative stress, enhanced cell stores of creatine, enhanced fertility in males with oligospermia, and greater defense against osteoporosis.

Primary / Asst. Examiners: Henley, III, Raymond;

INPADOC Legal Status: None          Buy Now: Family Legal Status Report

       
Related Applications:
Application Number Filed Patent Pub. Date  Title
US1997000807757 1997-02-27       


       
Parent Case:

CROSS-REFERENCE TO RELATED APPLICATIONS
    This application is a continuation-in-part of co-pending U.S. patent application Ser. No. 08/807,757 filed Feb. 27, 1997.

Family: Show 15 known family members

First Claim:
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What is claimed is:     1. A method of improving the health of a subject to increase the plasma level of arginine in the subject to a level from a low or normal fasting level to a level which is up to three times an average overnight fasting level, comprising orally administering a substance selected from the group consisting of L-citrulline and the calcium salt of L-citrulline.

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Forward References: Show 3 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (3)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 130(04)033039A CHEMABS 130(15)191896G CHEMABS 130(15)191896G DERABS C1998-430267

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