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 Title: |
US5917017:
Diphtheria toxin vaccines bearing a mutated R domain
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Collier, R. John; Wellesley Hills, MA
Shen, Wei Hai; Boston, MA
Eisenberg, David; Los Angeles, CA
Choe, Seunghyon; Solana Beach, CA
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| Assignee: |
President and Fellows of Harvard College, Cambridge, MA
The Regents of the University of California, Oakland, CA
other patents from HARVARD COLLEGE, PRESIDENT AND FELLOWS (242920) (approx. 503)
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| Published / Filed: |
1999-06-29
/ 1994-06-08
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| Application Number: |
US1994000257781
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| IPC Code: |
Advanced:
A61K 39/00;
A61K 39/05;
A61K 47/48;
A61P 31/04;
C07H 21/04;
C07K 14/255;
C07K 14/34;
C07K 16/12;
C07K 19/00;
C12N 1/21;
C12N 15/09;
C12P 21/02;
C12P 21/04;
C12P 21/08;
C12R 1/01;
C12R 1/07;
C12R 1/16;
C12R 1/19;
C12R 1/42;
C12R 1/63;
Core:
A61P 31/00;
C07H 21/00;
C07K 14/195;
more...
IPC-7:
A61K 39/00;
A61K 39/08;
C07K 1/00;
C12P 21/04;
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| ECLA Code: |
A61K47/48R2V; C07K14/34; C07K16/12;
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| U.S. Class: |
Current:
530/350;
424/183.1;
424/184.1;
424/185.1;
424/203.1;
424/236.1;
424/239.1;
424/245.1;
435/029;
435/069.1;
435/069.7;
Original:
530/350;
424/183.1;
424/184.1;
424/185.1;
424/203.1;
424/236.1;
424/245.1;
424/239.1;
435/069.1;
435/069.7;
435/029;
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| Field of Search: |
424/203.1,183.1,184.1,185.1,236.1,245.1,239.1
530/350
435/69.1,69.7,29
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| Government Interest: |
This invention was supported by NIH Grant Nos. AI22021 and AI22848 and the government has certain rights to this invention.
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| Priority Number: |
| 1994-06-08 |
US1994000257781 |
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| Abstract: |
Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Corynebacterium diphtheria.
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| Attorney, Agent or Firm: |
Fish & Richardson P.C. ;
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| Primary / Asst. Examiners: |
Minnifield, Nita;
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE CA EP JP
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| Family: |
Show 23 known family members
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First Claim:
Show all 27 claims |
What is claimed is:
1. A substantially pure polypeptide comprising a mutant diphtheria toxin R domain, said R domain comprising a mutation in at least one or more residues from the group consisting of Lys 516, Lys 526, Phe 530, and Lys 534 of wild-type diphtheria toxin, said polypeptide binds sensitive cells with less affinity than wild-type diphtheria toxin and forms an immune complex with an antibody which specifically recognizes the R domain of wild-type diphtheria toxin.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 2 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 124(15)200193F
DERABS C1996-039967
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| Other References: |
Aron, R., "Synthetic Vaccines" published 1987 by CRC Press (FL), pp. 40-71.
Haughten et al. 1986. Vaccines 86. New Approaches to Immunization. pp. 21-25. Fred Brown et al eds.
Davis et al (ed.) 1980. Immunology. pp. 291-295.
Rolf et al. 1991. ASM. Annual Mtg. Abstract Gen. Mtg. ASM. 91:75 Abs. # B-296.
Greenfield et al. 1987. Mutations in Diphtheria Toxin Separate . . . Science 238:536-539.
(4 pages)
Cited by 33 patents
Killeen et al. 1992. Reversion of recombinant toxoids: Mutations in diphtheria toxin . . . PNAS 89:6207-6209.
(3 pages)
Cited by 2 patents
[ISI abstract]
Rolf et al. 1990. Localization of the diphtheria toxin receptor-binding . . . JBC. 265(13):7331-7337.
(7 pages)
Cited by 2 patents
Fu et al. 1993. Receptor-binding domain of diphtheria toxin as a potential immunogen. Vaccines 93, pp. 379-383.
Bixler et al. 1987. B Cell Recognition of Protein Antigens . . . In:Synthetic Vaccines (ed. Arnon). vol. 1 pp. 39-71.
Anderson, "Antibody Responses to Haemophilus Influenzae Type B and Diphtheria Toxin Induced by Conjugates of Oligosaccharides of the Type b Capsule with the . . . ," Infection and Immunity 39:233-238, 1983.
(6 pages)
Cited by 24 patents
Anderson et al., "Immunogens Consisting of Oligosaccharides from the Capsule of Haemophilus influenzae Type b Coupled to Diphtheria Toxoid or the Toxin Protein CRM197," J Clin Invest 76:52-59, 1985.
(8 pages)
Cited by 10 patents
Anderson et al., "Effect of Oligosaccharide Chain Length, Exposed Terminal Group, and Hapten Loading on the Antibody Response of Human Adults and Infants to Vaccines . . . ," J of Immunology 142:2464-2468, 1989.
(5 pages)
Cited by 10 patents
Arnon, "Synthetic Peptides as the Basis for Future Vaccines," Trends Biochem. 11:521-524, 1986.
(4 pages)
Cited by 2 patents
Baseman et al., "Action of Diphtheria Toxin in the Guinea Pig," J. Exp. Med. 132:1138-1152, 1970.
Boquet et al., "Studies on the Role of a Nucleoside-Phosphate-Binding Site of Diphtheria Toxin in the Binding of Toxin to Vero Cells or Liposomes," Eur. J. Biochem. 121:93-98, 1981.
(6 pages)
Choe et al., "The Crystal structure of Diphtheria Toxin," Nature 357:216-222, 1992.
(7 pages)
Cited by 12 patents
[ISI abstract]
Eskola et al., "Antibody Levels Achieved in Infants by Course of Haemophilus Influenzae Type B Polysaccharide/Diphtheria Toxoid Conjugate Vaccine," Lancelet 1:1184-1186, 1985.
(3 pages)
Cited by 3 patents
Giannini et al., "The Amino Acid Sequence of Two Non-Toxic Mutants of Diphtheria Toxin: CRM45 and CRM197," Nucleic Acids Research 12:4063-4069, 1984.
(7 pages)
Cited by 11 patents
Greenfield et al., "Nucleotide Sequence of the Structural Gene for Diphtheria Toxin Carried by Corynebacteriophage B," Proc. Natl Acad Sci USA 80:6853-6857, 1983.
(5 pages)
Cited by 16 patents
McGill et al., "Membrane Interactions of Diphtheria Toxin Analyzed using in vitro Synthesized Mutants," The EMBO Journal 8:2843-2848, 1989.
(6 pages)
Cited by 2 patents
Rolf et al., "Further Characterization of the Diphtheria Toxin Receptor-Binding Domain within HA6DT," 1991, 75th Annual Mtg FASEB J. 5:A821, #2619.
(1 pages)
Cited by 2 patents
[ISI abstract]
Rolf et al., "Structure-Function Analyses of Diphtheria Toxin by Use of Monoclonal Antibodies," Infection & Immunity 61:994-1003, 1993.
(10 pages)
Cited by 3 patents
[ISI abstract]
Tang et al., "Genetic Immunization is a Simple Method for Eliciting an Immune Response," Nature 356:152-154 1992.
(3 pages)
Cited by 123 patents
[ISI abstract]
Uchida et al., "Mutation in the Structural Gene for Diphtheria Toxin Carried by Temperate Phage 6," Nature New Biology 233:8-11, 1971.
Wen et al., "Diphtheria Toxin-Related α-Melanocyte-Stimulating Hormone Fusion Toxin," J. Biol. Chem. 266: 12289-12293, 1991.
(5 pages)
Cited by 4 patents
[ISI abstract]
Zucker et al., "Monoclonal Antibody Analysis of Diphtheria Toxin-I. Localization of Epitopes and Neutralization of Cytotoxicity," Molecular Immunology 21:785-793, 1984.
(9 pages)
Cited by 4 patents
Zucker et al., "Monoclonal Antibody Analysis of Diphtheria Toxin-II. Inhibition of ADP-Ribosyl-Transferase Activity," Molecular Immunology 21:795-800, 1984.
(6 pages)
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| Continuity Data: |
| Application Number | Filed | Notes |
|---|
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US1994000257781 | 1994-06-08 | is a
related to the prior publication |
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US2002000224209 | 2002-08-20 | is a
division of |
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US1999000250131
| 1999-02-16 |
(granted)
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US6455673 issued 2002-09-24 Multi-mutant diphtheria toxin vaccines
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|
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US2002000224209 | | is a
division of |
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US1999000250131
| 1999-02-16 |
|
| |
US6455673 issued 2002-09-24 Multi-mutant diphtheria toxin vaccines
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|
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US1999000250131 | 1999-02-16 | is a
continuation in part of |
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>US1994000257781<
| 1994-06-08 |
(granted)
|
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US5917017 issued 1999-06-29 Diphtheria toxin vaccines bearing a mutated R domain
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|
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US1999000250131 | | is a
continuation in part of |
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>US1994000257781<
| 1994-06-08 |
|
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US5917017 issued 1999-06-29 Diphtheria toxin vaccines bearing a mutated R domain
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