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 Title: |
US5919652:
Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Pang, Shen; Van Nuys, CA
Belldegrun, Arie S.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
News, Profiles, Stocks and More about this company
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| Published / Filed: |
1999-07-06
/ 1995-09-01
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| Application Number: |
US1995000522841
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| IPC Code: |
Advanced:
A61K 48/00;
C12N 9/64;
C12N 15/85;
C12N 15/861;
Core:
more...
IPC-7:
C07H 21/04;
C12N 5/10;
C12N 15/85;
C12P 21/00;
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| ECLA Code: |
A61K48/00; C12N9/64F2C21M34; C12N15/85; C12N15/861; K61K48/00; M12N221/04; M12N830/00C; M12N830/15; M12N830/60; M12N830/85;
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| U.S. Class: |
Current:
435/069.1;
435/320.1;
435/325;
435/366;
536/024.1;
Original:
435/069.1;
435/320.1;
435/325;
435/366;
536/024.1;
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| Field of Search: |
435/69.1,172.1,172.3,240.2,320.1,325,366
536/23.1,23.5,24.1
424/93.2,93.6
514/044
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| Priority Number: |
| 1995-09-01 |
US1995000522841 |
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| Abstract: |
The present invention provides isolated or purified nucleic acid molecules comprising a prostate specific antigen (PSA) promoter alone or in combination with a cytomegalovirus (CMV) promoter.
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| Attorney, Agent or Firm: |
Mandel & Adriano ;
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| Primary / Asst. Examiners: |
Guzo, David;
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 125(07)078550Y
CHEMABS 131(06)069274H
CHEMABS 131(06)069274H
DERABS C1996-259574
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| Other References: |
Orkin et al., "Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy", Dec. 1995.
Klobeck et al., "Genomic sequence of human prostate specific antigen (PSA)," Nucleic Acids Research, vol. 17, No. 10, (1989) p. 3981.
(1 pages)
Cited by 3 patents
P.H. Riegman et al., "The Promoter of the Prostate-Specific Antigen Contains a Functional Androgen Responsive Element", Mol. Endo. (1991) vol. 5, No. 12, pp. 1921-1929 (Exhibit 1).
(10 pages)
Cited by 15 patents
[ISI abstract]
H. Brady et al., "Specific Ablation of Human Immunodeficiency Virus Tat-Expressing Cells by Conditionally Toxic Retroviruses", Proc. Natl. Acad. Sci. USA (1994) vol. 91, pp. 365-369 (Exhibit 2).
(5 pages)
Cited by 14 patents
[ISI abstract]
D. Chan et al., "Prostate-Specific Antigen as a Marker for Prostatic Cancer: a Monoclonal and a Polyclonal Immunoassay Compared", Clin. Chem. (1987) vol. 33, No. 10, pp. 1916-1920 (Exhibit 3).
(5 pages)
Cited by 8 patents
P. Murtha et al., "Characterization of an Androgen Response Element in the 5' Promoter Region of the Gene", Biochemistry (1993) vol. 32, No. 25, pp. 6459-6464 (Exhibit 4).
(6 pages)
Cited by 11 patents
[ISI abstract]
Z. Ram et al., "In Situ Retroviral-mediated Gene Transfer for the Treatment of Brain Tumors", Cancer Research (1993) Cancer Research, vol. 53, pp. 83-88 (Exhibit 5).
(6 pages)
Cited by 59 patents
[ISI abstract]
C. Lee et al., "Two-Dimensional Characterization of Prostatic Acid Phosphatase, Prostatic Specific Antigen and Prostate Binding Protein in Expressed Prostatic Fluid", The Prostate, 9:135-146, (1986) (Exhibit 6).
(12 pages)
H. Hoogenboom, "Targeting of Tumor Necrosis Factor to Tumor Cells: Secretion by Myeloma Cells of a Genetically Engineered Antibody-tumor Necrosis Factor Hybrid Molecule", Biochimica et Biophysica Acta, vol. 1096, (1991) pp. 345-354 (Exhibit 7).
(10 pages)
Cited by 17 patents
[ISI abstract]
C. Fong et al., "Regulation of Prostatic Carcinoma Cell Proliferation and Secretory Activity by Extracellular Matrix and Stromal Secretions", The Prostate, 21:121-131 (1992) pp. 121-131 (Exhibit 8).
(11 pages)
Cited by 4 patents
[ISI abstract]
M. Izawa, "cDNA Cloning of Androgen-Stimulated mRNAs in Rat Seminal Vesicles: Partial Characterization of Newly isolated cDNA Clones, pSv-1 and pSv-2", Endocrinol. Japon. 37 (2), (1990) pp. 223-232 (Exhibit 9).
(10 pages)
L. Venkatesh, "Selective Induction of Toxicity to Human Cells Expressing Human Immunodeficiency Virus Type 1 Tat by a Conditionally Cytotoxic Adenovirus Vector", Proc. Natl. Acad. Sci., vol. 87, pp. 8746-8750, (1990) (Exhibit 10).
(5 pages)
Cited by 13 patents
R. Henttu et al. "Androgens Up-Regulate the Human Prostate-Specific Antigen Messenger Ribonucleic Acid (mRNA), but Down-Regulate the Prostatic Acid Phosphatase mRNA in the LNCaP Cell Line", Endocrinology, vol. 130, No. 2, (1992) pp. 766-771 (Exhibit 11).
(7 pages)
[ISI abstract]
N. Ghyselinck et al., "Structural Organization and Regulation of the Gene for the Androgen-Dependent Glutathione Peroxidase-Like Protein Specific to the Mouse Epididymis", Molecular Endocrinology, (1993), pp. 258-269 (Exhibit 12).
(15 pages)
[ISI abstract]
G. Watwon et al., "Progressive Induction of mRNA Synthesis for Androgen-responsive Genes in Mouse Kidney", Molecular and Cellular Endocrinology, 68 (1990), pp. 67-74 (Exhibit 13).
L. Celis et al., "Proteins Interacting with an Androgen-responsive Unit in the C3(1) Gene Intron", Molecular and Cellular Endocrinology, 94 (1993) pp. 165-172 (Exhibit 14).
(8 pages)
[ISI abstract]
P. Rennie, et al., "Characterization of Two Cis-Acting DNA Elements Involved in the Androgen Regulation of the Probasin Gene", Molecular Endocrinology, vol. 7, No. 1, (1993), pp. 23-36 (Exhibit 15).
(14 pages)
Cited by 9 patents
[ISI abstract]
T. Wang et al., "Preliminary Evaluation of Measurement of Serum Prostate-Specific Antigen Level in Detection of Prostate Cancer", Annals of Clinical and Laboratory Science, vol. 16, No. 6, (1986), pp. 461-466 (Exhibit 16).
(6 pages)
N. Dawson, "Treatment of Progressive Metastatic Prostate Cancer", Oncology, vol. 7, No. 5, (1993), pp. 17-24 (Exhibit 17).
S. Pang et al., "High Levels of Unintegrated HIV-1 DNA in Brain Tissue of AIDS Dementia Patients", Nature, vol. 343, (1990), pp. 85-89 (Exhibit 18).
(5 pages)
Cited by 11 patents
S. Kuriyama et al., "A Potential Approach for Gene Therapy Targeting Hepatoma Using a Liver-Specific Promoter on a Retroviral Vector", Cell Structure and Function, vol. 16, (1991) pp. 503-509 (Exhibit 19).
(8 pages)
Cited by 21 patents
[ISI abstract]
C. Young et al., "Hormonal Regulation of Prostate-specific Antigen Messenger RNA in Human Prostatic Adenocarcinoma Cell Line LNCaP", Cancer Research, vol. 51, (1991) pp. 3748-3752 (Exhibit 20).
(5 pages)
Cited by 8 patents
[ISI abstract]
W. Tilley et al., "Androgen Receptor Gene Expression in Human Prostate Carcinoma Cell Lines", Cancer Research, vol. 50, (1990) pp. 5382-5386 (Exhibit 21).
(5 pages)
Cited by 4 patents
C. Huggins et al., "I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate", Studies on Prostatic Cancer, (1941), pp. 293-297 (Exhibit 22).
R. Vile et al., "In Vitro and in Vivo Targeting of Gene Expression to Melanoma Cells", Cancer Research, vol. 53, (1993), pp. 962-966 (Exhibit 23).
(6 pages)
Cited by 33 patents
[ISI abstract]
L. Emtage et al., "The Role of Prostate Specific Antigen in the Baseline Assessment of Patients Undergoing Hormone Therapy for Advanced Prostate Cancer", British Journal of Urology, (1987) 60:572-577 (Exhibit 24).
(6 pages)
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