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 Title: |
US5944684:
Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Roberts, Martin; North Hills, CA
Lee, David Be-Nyi; Encino, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1999-08-31
/ 1997-06-02
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| Application Number: |
US1997000866972
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| IPC Code: |
Advanced:
A61M 1/28;
A61M 1/16;
Core:
more...
IPC-7:
A61M 37/00;
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| ECLA Code: |
A61M1/28;
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| U.S. Class: |
Current:
604/005.04;
210/646;
604/006.09;
604/028;
604/029;
Original:
604/005;
604/004;
604/028;
604/029;
210/646;
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| Field of Search: |
604/004,5,6,28,29
210/259,638,646-648,650-651,806-807
128/898
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| Priority Number: |
| 1997-06-02 |
US1997000866972 |
| 1995-08-31 |
US1995000521357 |
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| Abstract: |
A wearable peritoneal dialysis device providing continuous removal of waste metabolites from the blood using a small volume (250-1000 mls) of protein-containing dialysate having an overall flow rate of about 2-3 liters per hour. The device may be worn in several places on the torso and limbs. Included are methods for peritoneal dialysis having improved efficiency, as well as methods for providing hormones, nutrients or therapeutic agents to a patient.
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| Attorney, Agent or Firm: |
Fish & Richardson P.C. ;
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| Primary / Asst. Examiners: |
Yu, Mickey; Cuddihy, Francis K.
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| INPADOC Legal Status: |
Show legal status actions
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| Parent Case: |
This is a continuation of application Ser. No. 08/521,357, filed Aug. 31, 1995, now abandoned.
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| Family: |
None
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First Claim:
Show all 7 claims |
What is claimed is:
1. A method for the continuous removal of protein-bound uremic toxins from the blood which enters the peritoneal cavity of a patient, comprising the steps of:
- a) introducing from about 250 to about 1000 ml of dialysate into the peritoneal cavity, wherein protein-bound uremic toxins from the blood translocate into said dialysate;
- b) removing the used dialysate from said peritoneal cavity;
- c) separating the used dialysate through a filter into a protein-containing fraction and an ultrafiltrate fraction;
- d) treating said ultrafiltrate fraction to remove waste products present in said ultrafiltrate fraction, thereby generating a purified ultrafiltrate fraction;
- e) treating said protein-containing fraction from said filter to remove undesirable proteins and noxious uremic substances bound to proteins, thereby generating detoxified proteins;
- f) combining said detoxified proteins and purified ultrafiltrate fraction to from regenerated dialysate;
- g) reintroducing said regenerated dialysate into the peritoneal cavity.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 25 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
DERABS C1999-526231
DERABS C1999-526231
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| Other References: |
Blumenkrantz, Michael J., et al., "An Integrated Approach to the Treatment of Patients with Multiple Organ System Failure Requiring Intensive Nutritional Support and Hemodialysis", (1984) Trans. Am. Soc. Artif. Intern. Organs, vol. XXX, pp. 468-472.
(5 pages)
Blumenkrantz, Michael J., et al., "Applications of the Redy Sorbant System to Hemodialysis and Peritoneal Dialysis", (1984) Artificial Organs, 3(3):.
Bosch, et al., "Filtration Peritoneal Dialysis: A Method to Eliminate Protein Loss", (1983) Blood Purif., 1:154-9.
Caparelli, A.W. et al., "Towards a Wearable Artificial Kidney for Continuous Dialysis: Ex-vivo Sorbant Regeneration of Filtered Peritoneal Dialysate during Intermittent Peritoneal Dialysis," (1993), Dialysis 4 (3):399.
Capparelli, A.W. et al., "Protein Loss During Peritoneal Dialysis (PD): Further Studies of Mechanisms and Benefits", (1995), Periton. Dialysis Int. 15 (S1):S6.
Curtis,J.R. and Sampson, B. "Aluminum Kinetics during Haemodialysis with the Redy 2000 Sorbsystem", (1989) Int. J. Artif. Organs, 12:683-7.
(5 pages)
Etteldorf, J.N., et al., "Intermittent Peritoneal Dialysis Using 5 Per Cent Albumin in the Treatment of Salicylate Intoxication of Children", (1961), J. Ped. 58 :226-36.
Gordon et al., "Augmentation of Efficiency by Continuous Flow Sorbent Regeneration Peritoneal Dialysis", (1976), Trans. Am. Soc. Artif. Intern. Organs, 22:599-603.
(6 pages)
Cited by 3 patents
Gordon, A. et al. "Sorbent Regenerating of Peritoneal Dialysate: An Approach to Ambulatory Dialysis", (1976-7) J. Dialysis 1(2): 145-64.
Lewin, A., et al., "Sorbent Based Regeneration Delivery System For Use In Peritoneal Dialysis", (1974), Trans. Am. Soc. Artif. Int. Organs, 20:130-3.
(4 pages)
Cited by 9 patents
Lewin, A.J. et al., "Clinical Application of a Sorbent-Based Peritoneal Dialysis Regeneration System", ASAIO 5 :48.
Lewin, A.J., et al., "Clinical Application of a Sorbent-Based Peritoneal Dialysate Regeneration System", XIIIth Cong. Abstracts Europ. Dial. Trans. Assoc. 27, Jun. 22, 1976.
Lewin, A.J., et al., "Sorbent Peritoneal Dialysis-Initial Clinical Trials", (1976), Dial. Transpl. Nephrol. 13 :284-92.
Lewin, A.J., et al., "Sorbent Based Regenerative Peritoneal Dialysis System", (1978), Dial. Transplant. 11 :831-2.
Meehan, et al., "Plasma Sulphate Levels in Haemodialysis Patients with Sorbant Regeneration", (1978) Aust. NZ J. Med., 8:235.
(1 pages)
Murisasco et al., "Continuous Arterio-Venous Hemofiltration in a Wearable Device to Treat End-stage Renal Disease", (1986), Trans. Am. Soc. Artif. Intern. Organs, 32:567-571.
Neff et al., "A Wearable Artificial Glomerulus", (1979) Trans. Am. Soc. Artif. Intern Organs, 25:71-73.
(3 pages)
Park, M.S. et al. "Albumin-based Solutions for Peritoneal Dialysis: Investigations with a Rat Model", (1995), Artificial Organs 19 (4):307-14.
(8 pages)
Cited by 2 patents
[ISI abstract]
Pierides and Frohnert, "Aluminum Related Dialysis Osteomalacia and Dementia after Prolonged Use of the Redy Cartridge", (1981), Trans. Am. Soc. Artif. Intern. Organs, 27:629-632.
(5 pages)
Raja, R.M., et al., "Recirculation Peritoneal Dialysis (RPD) with Sorbent Redy Cartridge", (1974), Nephr. Cong. 16 :113.
Roberts, M., et al. "Clinical Results in Patients on the Sorbent Recirculating Dialysate System (Redy) for Over 1 Year", (1974), Nephr. Congr. 16 :114.
Roberts, M., et al., "Regeneration of Peritoneal Dialysate (PD): A Step Towards a Continuous Wearable Artificial Kidney (CWAK)", (1991) J. Am. Nephrol. Soc. 2 :867.
Roberts, M., "Wearable Artificial Kidneys for Continuous Dialysis", (1993), ASAIO J. 39 :19-23.
Roberts, M., et al., "Sorbent Continuous Cyclic (CCPD) and Ambulatory (CAPD) Peritoneal Dialysis: Ex-vivo Clinical Evaluation", (1993) XIIth Int. Cong. Nephrol., p. 312.
Roberts, M., et al., "Development of a Wearable Artificial Kidney Based upon Sorbent Regeneration of Peritoneal Dialysate (PD)", Periton. Dial. Int. 15(4):S88.
Roberts, M. et al., "Peritoneal Dialysate (PD) Regeneration Using Commercially Available Redy Sorbent Cartridges: A Practical Means of Optimizing Continuous Cyclic Peritoneal Dialysis (CCPD)",(1994). J. Am Soc. Nephr. 5 :426.
(1 pages)
[ISI abstract]
Roberts, M., et al., "Ultrafilter Selection for Sorbent Continuous Cyclic (CCPD) and Ambulatory (CAPD) Peritoneal Dialysis", (1993) ASAIO Abstr., p. 115.
Roberts, M. et al. "Continuous Ambulatory Regenerative Dialysis (CARD)" (1992), J. Amer. Soc. Nephrol. 3:102.
Sarnatskaya, V.V., et al., "Peritoneal Dialysis for the Removal of Protein-Bound Markers of Hepatic Insufficiency", (1993) Artificial Organs 17 (10):828-36.
(9 pages)
[ISI abstract]
Shoji, S., et al., (1988), "Prototype Miniature Blood Gas Analyzer Fabricated on a Silicon Wafer", Sensors Actuators, 15:101-7.
(7 pages)
Cited by 18 patents
Stange et al., Dialysis Against a Recycled Albumin Solution Enables the Removal of Albumin-Bound Toxins, (1993), Artificial Organs, 17(9):809-13.
(5 pages)
[ISI abstract]
Tada, Y., et al., "A New Approach for the Filtrate Regeneration System in the Wearable Artificial Kidney", (1990) Artificial Organs, 14:405-9.
(5 pages)
Zalups, R.K., et al., "Factors Affecting Inorganic Mercury Transport and Toxicity in the Isolated Perfused Proximal Tubule", (1991) J. Am. Soc. Nephrol. 2 :866-78.
(13 pages)
[ISI abstract]
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