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Title: US5962294: Compositions and methods for the identification and synthesis of sialyltransferases
[ Derwent Title ]

Country: US United States of America

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57 pages

 
Inventor: Paulson, James C.; Sherman Oaks, CA
Wen, Xiaohong; San Diego, CA
Livingston, Brian; San Diego, CA
Gillespie, William; Culver City, CA
Kelm, Sorge; Kiel, Germany
Burlingame, Alma L.; Sausalito, CA
Medzihradszky, Katalin; San Francisco, CA

Assignee: The Regents of the University of California, Oakland, CA
Amgen, Inc., Thousand Oaks, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1999-10-05 / 1993-08-04

Application Number: US1993000102385
IPC Code: Advanced: C12N 9/10; C12N 15/09; C12N 15/54;
Core: more...
IPC-7: C12N 9/10;

ECLA Code: C12N9/10D9; M07K205/00; M07K319/00E2; M12N207/00; M12N213/02;

U.S. Class: Current: 435/193; 435/069.1; 435/252.3; 536/022.1; 536/023.1; 536/023.2; 536/023.5;
Original: 435/193; 435/069.1; 435/252.3; 536/023.1; 536/022.1; 536/023.2; 536/023.5;

Field of Search: 435/193,69.1,252.3,240.2 536/22.1,23.1,23.2,23.5

Government Interest:     This invention was made with Government support under Grant Nos. GM-27904 and GM-08042, awarded by the National Institutes of Health. The Government has certain rights in this invention.

Priority Number:
1993-08-04  US1993000102385
1992-08-04  US1992000925369
1992-03-09  US1992000850357

Abstract:     DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.

Attorney, Agent or Firm: Oppenheimer Wolff & Donnelly LLP ;

Primary / Asst. Examiners: Wax, Robert A.; Longton, Enrique D.
Maintenance Status: CC Certificate of Correction issued

INPADOC Legal Status: Show legal status actions          Buy Now: Family Legal Status Report

       
Related Applications:
Application Number Filed Patent Pub. Date  Title
US1992000925369 1992-08-04       
US1992000850357 1992-03-09       


       
Parent Case:     This application is a continuation-in-part of application Ser. No. 07/925,369 filed Aug. 4, 1992 now abandoned, which was a continuation-in-part of application Ser. No. 07/850,357 filed Mar. 9, 1992 now abandoned.

Designated Country: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE  BB BR KP KR LK MG MN MW OA PL RO RU SD 

Family: Show 35 known family members
First Claim:
Show all 4 claims		 What is claimed is:     1. A synthetic enzyme which exhibits sialyltransferase activity, said enzyme comprising a catalytic domain, said catalytic domain comprising a conserved region having amino acid SEQ. ID. NO:28 and wherein the amino acid sequence of said conserved region is not SEQ. ID NO:14, SEQ. ID NO:15 or SEQ. ID. NO:16.

Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 8 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (8)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 119(25)264178J CHEMABS 123(01)002767N CHEMABS 130(09)106031D DERABS C1993-303471 DERABS C1995-090894

Other References:
  • Sadler et al., "Purification to Homogeneity of a beta-Galactoside alpha2-3 Sialytransferase . . . ", Journal of Biological Chemistry, vol. 254, No. 11, pp. 4434-4443 (1979). (9 pages) Cited by 17 patents
  • Weinstein et al., "Purification of a Galbeta 1-4GlcNAc alpha2-6 Sialytransferase . . . ", Journal of Biological Chemistry, vol. 267, No. 22, pp. 13835-13844 (1962).
  • Nemansky et al., "Human liver and human placenta both contain CMP-NeuAc:Galbeta 1-4GlcNAc-R alpha2-3 . . . ", FEBS vol. 312, No. 1 pp. 31-36 Nov. (1992). (6 pages) [ISI abstract]
  • Mathews et al., "Mass Spectrometrically Derived . . . ", Journal of Biological Chemistry, vol. 262, No. 16, pp. 7537-7545 (1987). (9 pages) Cited by 3 patents
  • Lee et al., "Generation of cDNA Probed Directed by Amino Acid Sequence . . . ", Science vol. 239, pp. 1288-1291 (1988). (4 pages) Cited by 147 patents


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