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 Title: |
US5965534:
Use of ω-conotoxin analogs for treating retinal and optic nerve head damage
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Pang, Iok-Hou; Grand Prairie, TX
Kapin, Michael; Arlington, TX
Hellberg, Mark; Arlington, TX
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| Assignee: |
Alcon Laboratories, Inc., Fort Worth, TX
other patents from ALCON LABORATORIES, INC. (17225) (approx. 447)
News, Profiles, Stocks and More about this company
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| Published / Filed: |
1999-10-12
/ 1998-03-13
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| Application Number: |
US1998000039168
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| IPC Code: |
Advanced:
A61K 38/17;
Core:
more...
IPC-7:
A61K 38/00;
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| ECLA Code: |
A61K38/17;
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| U.S. Class: |
Current:
514/012;
424/078.04;
424/427;
514/013;
514/912;
530/324;
530/325;
530/857;
Original:
514/012;
514/013;
514/912;
530/324;
530/325;
530/857;
424/078.04;
424/427;
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| Field of Search: |
530/324,325,857
514/012,13,912
424/78.04,427
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| Priority Number: |
| 1998-03-13 |
US1998000039168 |
| 1995-11-22 |
US1995000562142 |
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| Abstract: |
The invention is directed to the use of ω-conotoxins for the prevention and treatment of retinal or optic nerve head damage in humans. Compositions and methods are disclosed.
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| Attorney, Agent or Firm: |
Mayo, Michael C. ;
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| Primary / Asst. Examiners: |
Tsang, Cecilia J.; Delacroix-Muirheid, C.
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| INPADOC Legal Status: |
Show legal status actions
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 131(21)291270N
CHEMABS 131(21)291270N
DERABS C1999-579926
DERABS C1999-579926
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| Other References: |
Benveniste, "Elevation of the Extracellular Concentrations of Glutamate and Asparate in Rat Hippocampus During Transient Cerebral Ishcemia Monitored by Intracerebral Microdialysis", Journal of Neurochemistry, vol. 43, No. 5, pp. 1369-1374 (1984).
(6 pages)
Cited by 10 patents
Choi, D., et al.; "Excitotoxic Cell Death", Journal of Neurobiology, vol. 23, No. 9, pp. 1261-1276 (1992).
(16 pages)
Cited by 19 patents
[ISI abstract]
Choi, D.; "Glutamate Neurotoxicity and Diseases of the Nervous System", Neuron, vol. 1, pp. 623-634 (1988).
(12 pages)
Cited by 114 patents
Cruz, L., et al.; "Characterization of the ω-Conotoxin Target. Evidence for Tissue-Specific Heterogeneity in Calcium Channel Types", Biochemistry, vol. 26, pp. 820-824 (1987).
(5 pages)
Cited by 13 patents
Cruz, L., et al.; "Conus Venoms: A Rich Source of Neuroactive Peptides", J. Toxicol.-Toxin Reviews, vol. 4, No. 2, pp. 107-132 (1985).
(26 pages)
David, P., et al.; "Involvement of Excitatory Neurotransmitters in the Damage Produced in Chick Embryo Retinas by Anoxia and Extracellular High Potassium", Exp. Eye Res., vol. 46, pp. 657-662 (1988).
(6 pages)
Cited by 11 patents
Deshpande, J., et al.; "Flunarizine, a Calcium Entry Blocker, Ameliorates Ischemic Brain Damage in the Rat", Anesthesiology, vol. 64, No. 2, pp. 215-224 (1986).
(10 pages)
Jones, O., et al.; "Localization and Mobility of ω-Conotoxin --Sensitive Ca2+ Channels in Hippocampal CA1 Neurons", Science, vol. 244, pp. 1189-1193 (1989).
(5 pages)
Cited by 4 patents
McCleskey, E., et al.; "ω-Conotoxin: Direct and persistent blockafe of specific types of calcium channels in neurons but not muscle", Proc. Natl. Acad. Sci. USA, vol. 84, pp. 4327-4331 (1987).
(5 pages)
Cited by 8 patents
Olney, J., et al.; "The Role of Specific Ions In Glutamate Neurotoxicity", Neuroscience Letters, vol. 65, pp. 65-71 (1986).
(7 pages)
Cited by 9 patents
Reynolds, I., et al.; "Brain voltage-sensitive calcium channel subtypes differentiated by ω-conotoxin fraction GVIA", Proc. Natl. Acad. Sci. USA, vol. 83, pp. 8804-8807 (1986).
(4 pages)
Sauter, A., et al.; "Treatment of Hypertension with Isradipine Reduces Infarct Size following Stroke in Laboratory Animals", The American Journal of Medicine, vol. 86 (suppl 4A), pp. 130-133 (1989).
(4 pages)
Scatton, B., et al.; "Eliprodil Hydrochloride", Drugs of the Future, vol. 19, No. 10, pp. 905-909 (1994).
Sheardown, M., et al.; "2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia", Science, vol. 247, pp. 571-574 (1990).
(4 pages)
Cited by 42 patents
Sher, E. et al.; "ω-Conotoxin binding and effects on calcium channel function in human neuroblastoma and rat pheochromocytoma cell lines", FEBS Letters, vol. 235, No. 1,2, pp. 178-182 (1988).
(5 pages)
Cited by 13 patents
Siesjo, "Calcium, Excitotoxins, and Brain Damage", NIPS, vol. 5, pp. 120-124 (1990).
(6 pages)
Cited by 3 patents
Siliprandi, R., et al.; "N-methyl-D-asparate-induced neurotoxicity in the adult rat retina", Visual Neuroscience, vol. 8, pp. 567-573 (1992).
(7 pages)
Cited by 11 patents
[ISI abstract]
Sisk, D., et al.; "Histologic changes in the inner retina of albino rates following intravitreal injection of monosodium L-glutamate", Graefe's Arch Clin Exp Ophthalmol, vol. 223, pp. 250-258 (1985).
(9 pages)
Cited by 12 patents
Smith, M., et al.; "Postischemic treatment with the Ω-conopeptide SNX 111 protects the rat brain against ischemic damage", J. Krieglstein, H. Oberpichler-Schwenk (Eds.) Pharmacology of Cerebral Ischemia, pp. 161-166 (1992).
Sucher, N. et al.; "N-methyl-D-asparate Antagonists Prevent Kainate Neurotoxicity in Rat Retinal Ganglion Cells in vitro", The Journal of Neuroscience, vol. 11, No. 4, pp. 966-971 (1991).
(6 pages)
Cited by 14 patents
[ISI abstract]
Tung, N., et al.; "A quantitative analysis of the effects of excitatory neurotoxins on retinal ganglion cells in the chick", Visual Neuroscience, vol. 4, pp. 217-223 (1990).
(7 pages)
Cited by 10 patents
Valentino, K., et al.; "A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia", Proc. Natl. Acad. Sci. USA, vol. 90, pp. 7894-7897 (1993).
(4 pages)
Cited by 3 patents
[ISI abstract]
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