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 Title: |
US5969096:
Conotoxin peptides
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Shon, Ki-Joon; Shaker Heights, OH
Gray, William R.; Salt Lake City, UT
Dykert, John; Vista, CA
Yoshikami, Doju; Salt Lake City, UT
Watkins, Maren; Salt Lake City, UT
Hillyard, David R.; Salt Lake City, UT
Rivier, Jean E. F.; La Jolla, CA
Olivera, Baldomero M.; Salt Lake City, UT
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| Assignee: |
The Salk Institute for Biological Studies, La Jolla, CA
University of Utah Research Foundation, Salt Lake City, UT
other patents from SALK INSTITUTE FOR BIOLOGICAL STUDIES (490315) (approx. 349)
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| Published / Filed: |
1999-10-19
/ 1998-06-26
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| Application Number: |
US1998000105715
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| IPC Code: |
Advanced:
C07K 14/435;
A61K 38/00;
Core:
more...
IPC-7:
A61K 38/00;
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| ECLA Code: |
C07K14/435A;
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| U.S. Class: |
Current:
530/325;
Original:
530/325;
514/013;
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| Field of Search: |
530/325
514/013
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| Government Interest: |
This invention was made with Government support under Grant Nos. GM-48677, GM-22737 and AM-26741, awarded by the National Institutes of Health. The Government has certain rights in this invention.
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| Priority Number: |
| 1998-06-26 |
US1998000105715 |
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| Abstract: |
Substantially pure conotoxin peptides are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular skeletal nAChRs to the exclusion of neuronal nAChRs. The peptides are of such length that they can be made by chemical synthesis, and the preferred peptides have formula: H-His-4Hyp-4Hyp-Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr-4Hyp-Gly-Cys-Ser-Ser-Ala-Ser-Cys-Cys-Gln-Xaa24 -NH2 wherein Xaa24 is Arg or Gly.
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| Attorney, Agent or Firm: |
Fitch, Even, Tabin & Flannery ;
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| Primary / Asst. Examiners: |
Tsang, Cecilia J.; Jameison, Fabian A.
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| Maintenance Status: |
E2 Expired Check current status
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| INPADOC Legal Status: |
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| Family: |
None
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First Claim:
Show all 11 claims |
What is claimed is:
1. A substantially pure conotoxin peptide having the formula (SEQ ID NO:1):
- H-His-Xaa2 -Xaa3 -Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr-Xaa14 -Gly-Cys-Ser-Ser-Ala-Ser-Cys-Cys-Gln-Xaa24 -NH2 wherein Xaa2, Xaa3 and Xaa14 are independently Pro or 4Hyp and Xaa24 is Arg or Gly.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 7 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 131(21)282649R
CHEMABS 131(21)282649R
DERABS C1999-590441
DERABS C1999-590441
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| Other References: |
Shon, et al., "A Non-competitive Inhibitor of the Nicotinic Acetlcholine Receptor fron Conus purpurascensVenom" Biochemistry 1997, 36, 9581.
(7 pages)
[ISI abstract]
Shon, et al., "Three-Dimensional Solution Structure of α-Conotoxin MII, an α3 β2 Neuronal Nicotinic Acetylcholine Receptor-Targeted Ligand", Reprinted from Biochemistry, vol. 36(50):15693-15700 (1997).
(8 pages)
[ISI abstract]
Advance ACS Abstract, Jul. 1, 1997, K. Shoen, et al., "Society for Neuroscience", 27th Annual Meeting, 1997.
Shon, et al., "A Noncompetitive Peptide Inhibitor of the Nicotinic Acetylcholine Receptor from Conus purpurascens Venom", Biochemistry, 36:9581-9587, 1997.
(7 pages)
[ISI abstract]
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