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 Title: |
US5973122:
Serum immunoregulatory polypeptides and uses therefor
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| Country: |
US United States of America
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| Inventor: |
Chang, Yi-Han; Los Angeles, CA
Abraham, Edward; Denver, CO
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1999-10-26
/ 1997-07-10
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| Application Number: |
US1997000891056
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| IPC Code: |
Advanced:
C07K 14/47;
C07K 16/18;
G01N 33/68;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
C07K 7/00;
C07K 14/745;
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| ECLA Code: |
C07K14/47A1; C07K16/18; G01N33/68D;
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| U.S. Class: |
Current:
530/380;
424/185.1;
530/300;
530/350;
530/395;
Original:
530/380;
530/300;
530/350;
530/395;
424/185.1;
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| Field of Search: |
530/300,350,380,395
424/185.1
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| Priority Number: |
| 1997-07-10 |
US1997000891056 |
| 1995-05-31 |
US1995000455645 |
| 1994-03-02 |
US1994000204486 |
| 1991-05-08 |
US1991000700110 |
| 1988-09-09 |
US1988000242739 |
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| Abstract: |
Previously unisolated serum immunoregulatory polypeptides (SIPs) having a molecular weight of approximately 14,000 to 31,000 are provided. The SIPs may be obtained from hemorrhagic serum of mammals and have been shown to activate suppressor T-cells and suppress lymphocyte proliferation and interleukin production. There is a significant homology between SIPs of different mammalian species. The amino acid sequence of an SIP having a molecular weight of about 16,000 is provided. In addition, immunosuppressive polypeptides are identified which have the formula (SEQ ID NO:2):
X-Met-Asp-Ala-His-Pro-Pro-Arg-Leu-Phe-Ala-Cys-Ser-Y
wherein X is an amino acid sequence having from 0 to 10 amino acids and Y is an amino acid sequence having from 0 to 110 amino acids.
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| Attorney, Agent or Firm: |
Oppenheimer Wolff & Donnelly LLP ;
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| Primary / Asst. Examiners: |
Cunningham, Thomas M.;
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| Maintenance Status: |
E1 Expired Check current status
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This is a continuation-in-part of application Ser. No. 08/455,645 filed May 31, 1995 (now U.S. Pat. No. 5,650,487) which is a continuation-in-part of application Ser. No. 08/204,486 filed Mar. 2, 1994 now abandoned; which is a continuation-in-part of Ser. No. 07/700,110 filed May 8, 1991 now abandoned; which is a file wrapper continuation of Ser. No. 07/242/739 filed Sep. 9, 1988, now abandoned.
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| Designated Country: |
BE CH DK ES FI FR GB GR IE IT LI LU MC NL PT SE RU
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| Family: |
Show 21 known family members
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| Claim |
What is claimed is:
1. A polypeptide which consists of the amino acid sequence set forth in SEQ. ID. NO. 1.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 113(11)096038U
CHEMABS 131(24)321549E
CHEMABS 126(08)099311G
CHEMABS 127(11)145183N
CHEMABS 130(11)138285F
CHEMABS 131(24)321549E
DERABS C1990-115957
DERABS C1997-034096
DERABS C1999-120777
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| Other References: |
Kwiatkowski, D.J. et al., Nature 323:455-58, "Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain."
Abraham et al., "Cellular and humoral bases of hemorrhage-induced depression of lymphocyte function," Critical Care Medicine, vol. 14, No. 2, pp. 81-86, 1986.
(6 pages)
Cited by 2 patents
McLoughlin et al., "Correlation between anergy and a circulating immunosuppressive factor following major surgical trauma," Ann. Surg., vol. 190, No. 3, pp. 297-304, 1979.
(8 pages)
Cited by 3 patents
Kohler et al., "Continuous cultures of fused cells secreting antibody of predefined specificity," Nature, vol. 256, pp. 495-497, 1975.
(3 pages)
Cited by 999 patents
Abraham et al., "Effects of hemorrhagic serum on interleukin-2 generation and utilization," Critical Care Medicine, vol. 16, No. 4, pp. 307-311, 1988.
(5 pages)
Cited by 2 patents
Abraham et al., "The role of interleukin 2 in hemorrhage-induced abnormalities of lymphocyte proliferation," Circulatory Shock, 18-205-213 (1986).
(9 pages)
Cited by 2 patents
Abraham et al., "Generation of functionally active suppressor cells by hemorrhage and haemorrhagic serum," Clin. exp. Immunol. (1988) 72, 238-242.
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