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 Title: |
US5989547:
Leptospiral outer membrane proteins
[ Derwent Title ]
>> View Certificate of Correction for this publication
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| Country: |
US United States of America
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| Inventor: |
Haake, David A.; Culver City, CA
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| Assignee: |
University of California, Los Angeles, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1999-11-23
/ 1997-01-21
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| Application Number: |
US1997000786074
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| IPC Code: |
Advanced:
A61P 31/04;
C07K 14/20;
A61K 39/00;
Core:
A61P 31/00;
C07K 14/195;
more...
IPC-7:
A61K 39/00;
A61K 39/02;
C07K 1/00;
C12P 21/04;
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| ECLA Code: |
C07K14/20;
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| U.S. Class: |
Current:
424/184.1;
424/190.1;
424/234.1;
424/262.1;
424/266.1;
435/071.1;
530/300;
530/350;
530/359;
Original:
424/184.1;
424/190.1;
424/262.1;
424/234.1;
424/266.1;
530/300;
530/350;
530/359;
435/071.1;
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| Field of Search: |
424/234.1,262.1,190.1,184.1,266.1
530/300,350,359
435/71.1
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| Government Interest: |
This invention was made with Government support through funding from the Veterans' Administration Medical Research Funds. The Government has certain rights in this invention.
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| Priority Number: |
| 1997-01-21 |
US1997000786074 |
| 1996-01-22 |
US1996000010316P |
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| Abstract: |
This invention presents antigenic preparations of Leptospira species outer membrane proteins and their immunogenic fragments which are useful for inducing immune response in animals, e.g., for use as vaccines against diseases caused by leptospirosis. Also presented are methods and kits for diagnosing leptospirosis by detecting the presence of these proteins, their immunogenic fragments, antibodies to these proteins or their fragments, or polynucleotides which encode or are translatable into these proteins or their fragments. Further disclosed are methods for isolating these proteins.
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| Attorney, Agent or Firm: |
Gray, Cary, Ware & Freidenrich, LLP ;
Haile, Lisa A. ;
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| Primary / Asst. Examiners: |
Minnifield, Nita;
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| Maintenance Status: |
CC Certificate of Correction issued
View Certificate of Correction
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
This application claims priority to provisional application Ser. 60/010316 filed Jan. 22, 1996, now abandoned.
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| Designated Country: |
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE AU CA EP IL JP
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| Family: |
Show 8 known family members
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First Claim:
Show all 10 claims |
I claim:
1. A method of inducing an immune response to a pathogenic spirochete in a subject comprising administering to the subject a pharmaceutical composition containing an immunogenically effective amount of isolated leptospiral outer membrane proteins having molecular masses, as indicated by denaturing polyacrylamide gel electrophoresis, selected from the group consisting of about 70-, about 74-, about 93-, about 101- and about 127-kDa.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 1 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 127(12)160565G
DERABS C1997-385293
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| Other References: |
Champion et al, Infect. Imm. 62(7): 2653-2661, Jul. 1994.
(9 pages)
Cited by 3 patents
[ISI abstract]
Brown et al, Infect & Imm. 59(5): 1772-1777, May 1991.
(6 pages)
Cited by 7 patents
[ISI abstract]
Alves, Selmo Fernandes, "Immunochemical and Protection Studies Analysis of Leptospira", Dissertation, University of California, Davis, approved by thesis committee in 1993 (Title Page, Table of Contents, Table 2).
Auran, et al., "Isolation of the Outer Sheath of Leptospira and Its Immunogenic Properties in Hamsters", Infect. Immun., 5:968-975 (1972).
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(6 pages)
Cited by 3 patents
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(12 pages)
Cited by 5 patents
[ISI abstract]
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(5 pages)
Cited by 4 patents
[ISI abstract]
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(8 pages)
Cited by 7 patents
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(10 pages)
Cited by 6 patents
[ISI abstract]
Haake, D. A., et al., "Molecular Cloning and Sequence Analysis of the Gene Encoding OmpL1, a Transmembrane Outer Membrane Protein of Pathogenic Leptospira spp,", J. Bacteriol., 175:4225-4234 (1993).
(10 pages)
Cited by 8 patents
[ISI abstract]
Holt, S. C., "Anatomy and Chemistry of Spirochetes", Microbiol. Rev., 42:114-160 (1978).
(47 pages)
Cited by 3 patents
Nicholson, et al., "Outer membrane proteins of three pathogenic Leptospira species", Veterinary Microbiology, 36:123-138 (1993).
(16 pages)
Cited by 7 patents
[ISI abstract]
Nunes-Edwards, P. L., et al., "Identification and Characterization of the Protein Antigens of Leptospira interrogans serovar hardjo", Infect. Immun., 48:492-497(1985).
(6 pages)
Cited by 5 patents
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Penn, et al., "The Outer Membrane of Treponema pallidum: Biological Significance and Biochemical Properties", J. Gen. Microbiol., 131:2349-2357 (1985).
(9 pages)
Cited by 7 patents
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(10 pages)
Cited by 3 patents
[ISI abstract]
Radolf, et al., "Characterization of Outer Membranes Isolated from Treponema pallidum, the Syphilis Spirochete", Infect. Immun., 63:4244-4252 (1995).
(9 pages)
Cited by 3 patents
[ISI abstract]
Shang, E. S. et al., "The Rare Outer Membrane Protein, OmpL1, of Pathogenic Leptospira Species Is a Heat-Modifiable Porin", Infect. Immun. 63(8):3174-3181 (1995).
(8 pages)
Cited by 4 patents
[ISI abstract]
Shang, E. S., et al., "Molecular Cloning and Sequence Analysis of the Gene Encoding LipL41, a Surface-Exposed Lipoprotein of Pathogenic Leptospira Species", Infect. Immun., 64:2322-2330 (1996).
(9 pages)
Cited by 5 patents
[ISI abstract]
Skare, et al., "Virulent Strain Associated Outer Membrane Proteins of Borrelia burgdorferi", J. Clin. Invest., 96:2380-2392 (1995).
(13 pages)
Cited by 2 patents
[ISI abstract]
Stamm, et al., "Changes in the Cell Surface Properties of Treponema pallidum that Occur During In Vitro Incubation of Freshly Extracted Organisms", Infect. Immun., 5:2255-261 (1987).
(7 pages)
Cited by 5 patents
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(5 pages)
Cited by 3 patents
[ISI abstract]
Weigel, L. M., et al., "Digoxigenin-Ampicillin Conjugate for Detection of Penicillin-Binding Proteins by Chemiluminescence", Antimicrob. Agents Chemother., 38(2):330-336 (1994).
(7 pages)
[ISI abstract]
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(12 pages)
Cited by 9 patents
[ISI abstract]
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