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Title: US5989904: Selective inhibition of internally initiated RNA translation
[ Derwent Title ]

Country: US United States of America

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37 pages

 
Inventor: Das, Saumitra; Los Angeles, CA
Dasgupta, Asim; Los Angeles, CA
Coward, Peter; San Francisco, CA

Assignee: The Regents of the University of California, Los Angeles, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1999-11-23 / 1997-10-06

Application Number: US1997000817953
IPC Code: Advanced: C12N 15/09; C12N 15/10; C12N 15/11; C12Q 1/68; A61K 38/00;
Core: more...
IPC-7: C07H 21/02; C07H 21/04; C12N 15/85;

ECLA Code: C12N15/10C11; C12N15/10C13; C12N15/10C14; C12N15/11B; C12N15/11B1; C12Q1/68P;

U.S. Class: Current: 435/320.1; 435/006; 435/325; 435/375; 435/455; 536/024.1; 536/024.5;
Original: 435/320.1; 435/006; 435/325; 435/375; 435/455; 536/024.1; 536/024.5;

Field of Search: 435/006,177.3,375,377,325,455 536/24.1,24.5 514/044

Priority Number:
1997-10-06  US1997000817953
1994-10-11  US1994000321427
1995-10-11  WO1995US0012615

Abstract:     PCT No. PCT/US95/12615 Sec. 371 Date Oct. 6, 1997 Sec. 102(e) Date Oct. 6, 1997 PCT Filed Oct. 11, 1995 PCT Pub. No. WO96/11211 PCT Pub. Date Apr. 18, 1996A method to inhibit translation of an mRNA, which is intitiated at an internal ribosome entry site of the mRNA and requires binding of a protein factor to that site, is disclosed. The method comprises a step of providing, in an in vitro, or in vivo system that is capable of translating the mNRA, an inhibitory effective amount of a molecule that selectively binds to the protein factor, thereby preventing that factor from binding to the mNRA. The inhibitor molecule is an RNA oligonucleotide consisting of less than 35 nucleotides or a structural mimic of such an RNA oligonucleotide. Nucleotide sequences of such inhibitor RNA oligonucleotides include portions of the following sequences: the 60 nucleotide sequence of a yeast inhibitor RNA or of the sequence complementary to that yeast inhibitor RNA; nucleotides 186-220 of poliovirus (stem-loop D); nucleotides 578-618 of poliovirus (stem-loop G); nucleotides 260-415 of poliovirus (stem-loop E); nucleotides 448-556 of poliovirus (stemp-loop F); and the sequence of the internal ribosome entry site of the immunoglobulin heavy chain binding protein (Bip).

Attorney, Agent or Firm: Morrison & Foerster, LLP ;

Primary / Asst. Examiners: LeGuyader, John; McGarry, Sean
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Related Applications: Go to Result Set: 1 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1994000321427 1994-10-11       


       
Parent Case:     This application is a 371 of PCT/US95/12615, and a continuation-in-part of application U.S. Ser. No. 08/321,427 filed 11 Oct. 1994, the disclosure of which is incorporated by reference in its entirety. This invention was made with funding from National Institutes of Health Grant Nos. AI-18272, AI-27451 and AI-38056. The U.S. Government has certain rights in this invention.

Designated Country: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE  CA EP JP US 

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First Claim:
Show all 4 claims		 We claim:     1. A molecule that inhibits translation of an mRNA, which translation is initiated at an internal ribosome entry site of said mRNA and requires binding of a protein factor to said site, said molecule selectively binding to said factor, thereby preventing said factor from binding to said site of said mRNA, wherein said molecule is an RNA oligonucleotide consisting of less than 35 nucleotides, and wherein the nucleotide sequence of said RNA oligonucleotide is 5'GCGCGGGCAGCGCA3'(SEQ ID NO:1).

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PCT Number: PCT/US95/12615    WO9611211

PCT Pub./Filed Dates: 1996-04-18 / 1995-10-11

§ 371 / 102(e) Dates: 1997-10-06 / 1997-10-06

Forward References: Show 4 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (4)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 125(03)027692P CHEMABS 131(26)347576M CHEMABS 131(26)347576M DERABS C1996-209808

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