 |
|
|
|
|
|
 Title: |
US5998366:
Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders
[ Derwent Title ]
|
| Country: |
US United States of America
|
| |
| Inventor: |
Tobin, Allan J.; Los Angeles, CA
Erlander, Mark G.; Tarzana, CA
Kaufman, Daniel L.; Santa Monica, CA
|
| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
News, Profiles, Stocks and More about this company
|
| Published / Filed: |
1999-12-07
/ 1997-04-09
|
| Application Number: |
US1997000827618
|
| IPC Code: |
Advanced:
C07K 14/47;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
C07K 14/00;
C12N 9/00;
|
| ECLA Code: |
C07K14/47A5; K61K38/00; M12N207/00; S01N800/04A; S01N800/24;
|
| U.S. Class: |
Current:
514/012;
424/094.1;
424/094.5;
435/183;
435/232;
514/014;
514/015;
514/016;
514/017;
530/327;
530/328;
530/329;
530/330;
Original:
514/012;
514/014;
514/015;
514/016;
514/017;
530/330;
530/329;
530/328;
530/327;
435/183;
435/232;
424/094.5;
424/094.1;
|
| Field of Search: |
514/002,12,14,15,16,17
435/232,183
530/330,329,328,327
424/94.5,94.1
|
| Government Interest: |
The present invention was supported by Grant NS22256 from the National Institutes of Health. The United States Government has certain rights in this invention.
|
| Priority Number: |
| 1997-04-09 |
US1997000827618 |
| 1995-06-07 |
US1995000485725 |
| 1991-06-18 |
US1991000716909 |
| 1990-09-21 |
US1990000586536 |
|
| Abstract: |
Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.
|
| Attorney, Agent or Firm: |
Trecartin, Richard F.Flehr Hohbach Test Albritton & Herbert LLP ;
|
| Primary / Asst. Examiners: |
Carlson, Karen Cochrane;
|
| INPADOC Legal Status: |
None
Family Legal Status Report
|
| Parent Case: |
This is a division of application Ser. No. 08/485,725 filed Jun. 7, 1995, which is a continuation-in-part of Ser. No. 07/716,909 filed Jun. 18, 1991, now abandoned, which is a continuation-in-part of Ser. No. 07/586,536 filed Sep. 21, 1990, now abandoned.
|
| Designated Country: |
BE CH FR GB IT LI LU MC NL PT SE NO
|
| Family: |
Show 67 known family members
|
First Claim:
Show all 36 claims |
We claim:
1. A method for ameliorating a GAD-associated autoimmune disorder in a patient having the disorder, said method comprising administering to the patient a GAD65 peptide consisting of the amino acid sequence selected from the group consisting of:
- KPCSCSKVDVNYAFLHATDL (SEQ ID NO:06);
- NMYAMMIARFKMFPEVKEKG (SEQ ID NO:07);
- TAGTTVYGAFDPLLAVADICKK (SEQ ID NO:08);
- EYLYNIIKNREGYEMVFDGK (SEQ ID NO:09);
- IPPSLRYLEDNEERMSRLSK (SEQ ID NO:10);
- SRLSKVAPVIKARMMEYGTT (SEQ ID NO:11);
- EYGTTMVSYQPLGDKVNFFR (SEQ ID NO:12);
- ATHQDIDFLIEEIERLGQDL (SEQ ID NO:13);
- QKFTGGIGNKLCALLYGD (SEQ ID NO:60);
- LLYGDAEKPAESGGSQPPRA (SEQ ID NO:17);
- KPCSCSKVDVNYAFLHATDL (SEQ ID NO:06);
- LAFLQDVMNILLQYVVKSFDRS (SEQ ID NO:21);
- EEILMHCQTTLKYAIKTGHP (SEQ ID NO:24);
- AFTSEHSHFSLKKGAAALGI (SEQ ID NO:32);
- AALGIGTDSVILIKCDERGK (SEQ ID NO:33);
- DERGKMIPSDLERRILEAKQ (SEQ ID NO:34);
- LEAKQKGFVPFLVSATAGTT (SEQ ID NO:35);
- GLLMSRKHKWKLSGVERANS (SEQ ID NO:38);
- VPLQCSALLVREEGLMQNCNQ (SEQ ID NO:40);
- KHYDLSYDTGDKALQCGRHV (SEQ ID NO:42);
- IPPSLRTLEDNEERMSRLSK (SEQ ID NO:47);
- VNFFRMVISNPAATHQDIDF (SEQ ID NO:50);
- amino acids 224-398 of SEQ ID NO:57; and
- amino acids 398-585 of SEQ ID NO:57.
|
| Background / Summary: |
Show background / summary
|
| Drawing Descriptions: |
Show drawing descriptions
|
| Description: |
Show description
|
| Forward References: |
Show 4 U.S. patent(s) that reference this one
|
|
|
|
|
|
|
| Foreign References: |
|
| Other Abstract Info: |
CHEMABS 117(23)227775Q
DERABS C2000-095930
CHEMABS 118(23)225673B
CHEMABS 127(23)315578Q
DERABS C1992-150489
DERABS C1992-425701
DERABS C2000-095930
DERABS C2000-500251
|
| Other References: |
Baekkeskov et al., "Revelation of Specificity of 64K Autoantibodies in IDDM Serums by High-Resolution 2-D Gel Electrophoresis," Diabetes, 38:1133-1141 (1989).
(9 pages)
Cited by 9 patents
Wraith et al., "Antigen Recognition in Autoimmune Encephalomyelitis and the Potential for Peptide-Mediated Immunotherapy," Cell, 59:247-255 (1989).
(9 pages)
Cited by 56 patents
Gerling et al., "Effect of Coxsackievirus B4 Infection in Mice on Expression of 64,000-M Autoantigen and Glucose Sensitivity of Islets Before Development of . . . ," Diabetes, 37:1419-1425 (1988).
(7 pages)
Cited by 6 patents
Dryberg, "Molecular Mimicry and Diabetes," Current Topics in Microbiology & Immun., 145:118-125 (1989).
Julien et al., "Rat Brain Glutamic Acid Decarboxylase Sequence Deduced from a Cloned cDNA," J. Of Neurochemistry, 54:703-705 (1990).
(3 pages)
Cited by 16 patents
Schwimmbeck et al., "Molecular Mimicry and Myasthenia Gravis," J. Clin. Invest. 84:1174-1180 (1989).
(7 pages)
Cited by 7 patents
Todd et al., "A Molecular Basis for Genetic Susceptibility to Insulin-Dependent Diabetes Mellitus," TIG, 4:129-134 (1988).
(6 pages)
Cited by 7 patents
Chang and Gottlieb, "Characterization of the Proteins Purified with Monoclonal Antibodies to Glutamic Acid Decarboxylase," J. Of Neuroscience, 6:2123-2130 (1988).
(8 pages)
Cited by 14 patents
Legay et al., "Evidence for Two Distinct Forms of Native Glutamic Acid Decarboxylase in Rat Brain Soluble Extract: An Immunoblotting Study," J. Of Neurochemistry, 48:1022-1026 (1987).
(5 pages)
Cited by 9 patents
Julien et al., "Molecular Cloning, Expression and in situ Hybridization of Rat Brain Glutamic Acid Decarboxylase Messenger RNA," Neuroscience Letters, 73:173-180 (1987).
(8 pages)
Cited by 9 patents
Baekkeskov et al., "Identification of the 64K Autoantigen in Insulin-Dependent Diabetes as the GABA-Synthesizing Enzyme Glumatic Acid Decarboxylase," Nature, 347:151-156 (1990).
(6 pages)
Cited by 44 patents
Michelesen et al., "Cloning, Characterization, and Autoimmune Recognition of Rat Islet Glutamci Acid Decarboxylase in Insulin-Dependent Diabetes Mellitus," PNAS USA, 88:8754-8758 (1991).
(5 pages)
Cited by 13 patents
[ISI abstract]
Solimena et al., "Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiffman Syndrom," N. Engl. J. Med., 322:1555-1560 (1990).
(6 pages)
Cited by 13 patents
Kobayashi et al., "Glutamic Acid Decarboxylase cDNA: Nucleotide Sequence Encoding an Enzymatically Active Fusion Protein," J. Of Neuroscience, 9:2768-2772 (1987).
(5 pages)
Cited by 10 patents
Atkinson and Maclaren, "What Causes Diabetes?" Sci. Amer., 62-71 (1990).
Cited by 12 patents
Baekkeskov et al., "Autoantibodies in Newly Diagnosed Diabetic Children Immunoprecipitate Human Pancreatic Islet Cell Proteins," Nature, 298:167-169 (1982).
(3 pages)
Cited by 32 patents
Baekkeskov et al., "Antibodies to a 64,000 MΓ Human Inslet Cell Antigen Precede the Clinical Onset of Insulin-Dependent Diabetes," J. Clin. Invest., 79;926-934 (1987).
(9 pages)
Cited by 23 patents
Christie et al., "Cellular and Subcelluar Localization of an MΓ 64,000 Protein Autoantigen in Insulin-Dependent Diabetes," J. Biol. Chem., 265:376-381 (1990).
(6 pages)
Cited by 14 patents
Atkinson et al., "64,000 MΓ Autoantibodies as Predictors of Insulin-Dependent Diabetes," The Lancet, 335:1357-1360 (1990).
(4 pages)
Cited by 19 patents
Ziegler et al., "Predicting Type 1 Diabetes," Diabetes Care, 13:762-775 (1990).
(14 pages)
Cited by 11 patents
Kaufman et al., "Brain Glutamate Decaroxylase Cloned in .lambda.gt-11: Fusion Protein Produces T-Aminobutyric Acid," Science, 232:1138-1140 (1986).
(3 pages)
Cited by 16 patents
Wyborski et al., "Characterization of a cDNA Coding for Rat Glutamic Acid Decarboxylase," Molecular Brain Research, 8:193-198 (1990).
(6 pages)
Cited by 10 patents
Katarova et al., "Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the Mouse," European J. Of Neuroscience, 2:190-202 (1990).
(13 pages)
Cited by 10 patents
Persson et al., "Expression of the Neurotransmitter-Synthesizing Enzyme Glutamic Acid Decarboxylase in Male Germ Cells," Molecular and Cellular Biology, 10:4701-4711 (1990).
(11 pages)
Cited by 10 patents
|
|
 Nominate this for the Gallery...
|
|
