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 Title: |
US5998374:
Clavaspirins
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Lehrer, Robert I.; Santa Monica, CA
Lee, In-Hee; Seoul, Republic of Korea
Zhao, Chengquan; Los Angeles, CA
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| Assignee: |
The Regents of University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1999-12-07
/ 1997-02-28
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| Application Number: |
US1997000808277
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| IPC Code: |
Advanced:
A61P 43/00;
C07K 14/435;
C12N 15/12;
A61K 38/00;
Core:
more...
IPC-7:
A61K 38/17;
C07K 14/435;
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| ECLA Code: |
C07K14/435A;
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| U.S. Class: |
Current:
514/013;
530/323;
530/326;
530/332;
Original:
514/013;
530/323;
530/326;
530/332;
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| Field of Search: |
514/013
530/323,326,332
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| Government Interest: |
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT
This invention was made at least in part with funding from NIH grant numbers 1-PO1-AI-37945-01 and 5R37-AI-22839-10. The U.S. Government has certain rights in this invention.
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| Priority Number: |
| 1997-02-28 |
US1997000808277 |
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| Abstract: |
Novel microbial peptides called clavaspirins are of the formula (SEQ ID NO:1)
X'1 X2 B'3 X4 X5 U6 U7 X8 X9 B10 X'11 X12 U13 B14 X15 X16 B*17 B18 X19 U20 X21 X'22 X23 (1)
including the salts, esters, amides and acylated forms thereof
- wherein X is a hydrophobic amino acid residue or modified form thereof;
- X' is a small or a hydrophobic amino acid residue or a modified form thereof;
- B is a basic amino acid residue or modified form thereof;
- B' is basic or a polar/large amino acid residue or modified form thereof;
- B* is a basic or a hydrophobic amino acid residue or a modified form thereof; and
- U is a small amino acid residue or modified form thereof.
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| Attorney, Agent or Firm: |
Morrison & Foerster LLP ;
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| Primary / Asst. Examiners: |
Prouty, Rebecca E.;
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| Maintenance Status: |
E2 Expired Check current status
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
AU CA EP JP
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| Family: |
Show 3 known family members
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First Claim:
Show all 12 claims |
We claim:
1. A compound in purified and isolated form, having antimicrobial activity of the formula (SEQ ID NO:1)
X'1 X2 B'3 X4 X5 U6 U7 X8 X9 B10 X'11 X12 U13 B14 X15 X16 B*17 B18 X19 U20 X21 X'22 X23 ( 1)
- including the salts, esters, amides and acylated forms thereof
- wherein
- X'1 is Phe, Trp, Tyr, or Ala; and
- X2 is Val, Leu, Ile, Phe, Trp or Tyr; and
- B'3 is Asn, Gln, His, Lys or Arg; and
- X4 and X5 is each independently selected from the group consisting of Phe, Leu, Tyr, Ile and Val; and
- U6 is Gly, Ser or Ala; and
- X8 and X9 is each independently selected from the group consisting of Ile, Leu and Val; and
- B10 is His, Lys or Arg; and
- X'11 is Ala, Ser or Gly; and
- X12 is Val, Ile or Leu; and
- U13 is Ala, Ser or Gly; and
- B14 is Arg, Lys or His; and
- X15 and X16 is each independently selected from the group consisting of Val, Leu and Ile; and
- B*17 is His, Lys, Arg, Trp, Phe or Tyr or a modified form thereof; and
- B18 is Arg, Lys or His; and
- X19 is Leu, Ile or Val; and
- U20 is Gly, Ala or Ser; and
- X21 is Ile, Val or Leu; and
- X'22 is Ala, Ser or Gly; and
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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