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 Title: |
US6001848:
Bromocriptine for the treatment of alcoholics diagnosed with the D2 dopamine receptor DRD2 A1 allele
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Noble, Ernest P.; South Laguna, CA
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| Assignee: |
The Regents of the University of California, Los Angeles, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1999-12-14
/ 1997-03-24
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| Application Number: |
US1997000822659
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| IPC Code: |
Advanced:
A61K 31/48;
A61K 31/485;
A61K 31/495;
Core:
more...
IPC-7:
A61K 31/44;
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| ECLA Code: |
A61K31/48; A61K31/48+M; A61K31/485+M; A61K31/495+M;
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| U.S. Class: |
Current:
514/288;
514/282;
514/284;
514/651;
514/811;
Original:
514/288;
514/282;
514/284;
514/651;
514/811;
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| Field of Search: |
514/282,284,288,651,811
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| Priority Number: |
| 1997-03-24 |
US1997000822659 |
| 1996-03-25 |
US1996000014136P |
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| Abstract: |
Disclosed are dopamine agonist and opioidergic compositions and methods for their use in the treatment of alcoholism. The invention discloses compounds and therapeutic kits useful in the treatment of alcoholics having the A1 allele of the dopamine receptor D2 gene. Also disclosed are methods of treating alcoholics having the A1/A1 or A1/A2 DRD2 genotype comprising administration of dopamine agonists such as aporphines, ergolines, related compounds, and their analogs, in combination with opioidergic compounds such as naloxone.
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| Attorney, Agent or Firm: |
Arnold, White & Durkee ;
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| Primary / Asst. Examiners: |
Moezie, M.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
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| Parent Case: |
The present application is a continuing application based on U.S. Provisional Patent Ser. No. 60/014,136, filed Mar. 25, 1996, the entire content of which is incorporated herein by reference.
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| Family: |
None
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First Claim:
Show all 4 claims |
What is claimed is:
1. A method of alleviatig alcohol addiction in a human having a D2 dopamine receptor A1 allele, the method comprising the steps of:
- (a) obtainig nucleic acids from a blood sample of said human
- (b) identifying in said nucleic acids a D2 dopamine receptor A1 allele; and
- (c) administering to said human an amount of DRD2-specific dopamine agonist sufficient to alleviate said alcohol addiction, wherein said dopamine agonist is bromocriptine.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 1 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 132(03)019989V
CHEMABS 132(03)019989V
DERABS C2000-061896
DERABS C2000-061896
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| Other References: |
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(7 pages)
Cited by 3 patents
[ISI abstract]
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(7 pages)
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(6 pages)
[ISI abstract]
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[ISI abstract]
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Cited by 2 patents
[ISI abstract]
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(9 pages)
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(11 pages)
[ISI abstract]
Noble and Blum, "Alcoholism and the D2 Receptor Gene (Letter)," J. Am. Med. Assoc., 270;1547, Oct. 1993.
(1 pages)
[ISI abstract]
Noble et al., "Allelic Association of the D2 Dopamine Receptor Gene with Receptor-Binding Characteristics in Alcoholism," Arch. Gen. Psychiatr., 48:648-654, Jul. 1991.
(7 pages)
Cited by 2 patents
[ISI abstract]
Noble et al., "Allelic Association of the D2 Dopamine Receptor Gene with cocaine Dependence," Drug. Alc. Depend., 33:271-285, 1993.
(15 pages)
Cited by 2 patents
[ISI abstract]
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(11 pages)
Cited by 2 patents
[ISI abstract]
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(13 pages)
Cited by 2 patents
[ISI abstract]
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(4 pages)
Cited by 2 patents
[ISI abstract]
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(14 pages)
Cited by 2 patents
[ISI abstract]
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(4 pages)
[ISI abstract]
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(9 pages)
[ISI abstract]
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(11 pages)
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(8 pages)
Borg and Weinholdt, "Bromocriptine in the Treatment of the Alcohol-Withdrawal Syndrome," Acta Psychiat. Scand., 65:101-111, 1982.
(11 pages)
Dongier et al., "Bromocriptine in the Treatment of Alcohol Dependence," Alcoholism, 15:970-977, Nov./Dec. 1991.
(8 pages)
[ISI abstract]
Powell et al., "A Double-Blind, Placebo-Controlled Study of Nortriptyline and Bromocriptine in Male Alcoholic Subtyped by Comorbid Psychiatric Disorders," Alcoholism, 19:463-468, Apr. 1995.
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(15 pages)
Cited by 2 patents
Litten and Allen, "Pharmacotherapies for Alcoholism: Promising Agents and Clinical Issues," Alcoholism, 15:620-633, Jul./Aug. 1991.
(14 pages)
[ISI abstract]
Gorelick, "Medications for the Treatment of Substance Abuse," Curr. Opin. Psychiatr., 5:430-435, 1992.
Lawford et al., "Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele," Nature Med., 1:337-341, Apr. 1995.
(5 pages)
Cited by 2 patents
[ISI abstract]
O'Brien, "Rat study sheds light on cocaine craving", Science, 271:1499, Mar. 1996.
(1 pages)
Cited by 2 patents
[ISI abstract]
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(6 pages)
Cited by 2 patents
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(4 pages)
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(4 pages)
Cited by 2 patents
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(10 pages)
[ISI abstract]
Giannini et al., "Bromocriptine and amantadine in cocaine detoxification", Psychiatry Res., 29:11-16, 1989.
(6 pages)
Cited by 5 patents
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(8 pages)
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(1 pages)
[ISI abstract]
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(2 pages)
[ISI abstract]
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(10 pages)
Cited by 2 patents
[ISI abstract]
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(6 pages)
[ISI abstract]
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(9 pages)
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(6 pages)
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[ISI abstract]
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(5 pages)
Cited by 2 patents
[ISI abstract]
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