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Title: US6013660: Externally targeted prophylactic and chemotherapeutic method and agents
[ Derwent Title ]


Country: US United States of America

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54 pages

 
Inventor: Horwitz, Marcus A.; Los Angeles, CA
Harth, Gunter; Los Angeles, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2000-01-11 / 1996-10-02

Application Number: US1996000724814

IPC Code: Advanced: C12N 9/00; C12N 9/99;
Core: more...
IPC-7: A01N 37/12; A01N 43/50;

ECLA Code: C12N9/00L; C12N9/99;

U.S. Class: Current: 514/401; 514/566;
Original: 514/401; 514/566;

Field of Search: 435/184 514/579,607 562/401,566

Government Interest:

REFERENCE TO GOVERNMENT
    This invention was made with Government support under Grant No. AI-35275 awarded by the Department of Health and Human Services. The Government has certain rights in this invention.

Priority Number:
1996-10-02  US1996000724814

Abstract: Methods and associated compositions are provided for the effective treatment of mammalian disease conditions associated with infection by pathogenic organisms through the identification of extracellular enzymes necessary for the growth or survival of the pathogenic organism and the subsequent interference with the functional activity of the identified extracellular enzyme to an extent sufficient to significantly inhibit the growth or survival of the pathogenic organism.

Attorney, Agent or Firm: Oppenheimer, Wolff & Donnelly, L.L.P. ;

Primary / Asst. Examiners: Degen, Nancy; Wang, Andrew

Maintenance Status: CC Certificate of Correction issued

INPADOC Legal Status: Show legal status actions          Buy Now: Family Legal Status Report

Designated Country: CA EP JP 

Family: Show 2 known family members

First Claim:
Show all 2 claims
What is claimed is:     1. A method for treating mammalian disease conditions associated with infection by pathogenic mycobacterium, said method comprising the steps of:
  • administrating L-methionine-S-sulfoximine to a mammal in a dose sufficient to significantly inhibit the growth or survival of the pathogenic mycobacterium without harming said mammal.


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U.S. References: Go to Result Set: All U.S. references   |  No patents reference this one   |   Backward references (19)   |   Citation Link

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Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 3pp US3888837  1975-06 Tsumita et al.  Mitsui Pharmaceuticals, Incorporated TUBERCULIN ACTIVE PROTEINS AND PEPTIDES FROM THE CELLS OF TUBERCLE BACILLI
Buy PDF- 3pp US3943119  1976-03 Tsumita et al.  Mitsui Pharmaceuticals, Incorporated Tuberculin active proteins and peptides from the cells of tubercle bacilli
Buy PDF- 14pp US4123427  1978-10 Daniel   Method for the purification of mycobacterial protein antigens and resulting product
Buy PDF- 5pp US4285931  1981-08 Limjuco et al.  Merck & Co., Inc. E. coli enterotoxin vaccine for veterinary and human use
Buy PDF- 8pp US4460503  1984-07 Savrda et al.  Institut Pasteur Tuberculine active peptides and a process for preparing same by chemical synthesis
Buy PDF- 3pp US4724144  1988-02 Rook et al.  University College London Immuno-therapeutic composition of killed cells from mycobacterium vaccae
Buy PDF- 8pp US4777130  1988-10 Maes  Andra Biologicals Isolation of mycobacterial a 60 antigen for diagnostic purposes
Buy PDF- 15pp US4889800  1989-12 Shinnick et al.  Scripps Clinic and Research Foundation Synthetic polypeptides and receptor molecules derived therefrom and methods of use
Buy PDF- 17pp US4906742  1990-03 Young et al.  Whitehead Institute for Biomedical Research Encoding antigens of M. Leprae
Buy PDF- 24pp US4952395  1990-08 Shinnick et al.  Scripps Clinic and Research Foundation Mycobacterial recombinants and peptides
Buy PDF- 11pp US4965192  1990-10 Maes  Anda Biologicals A60-antigen from Mycobacteria and use thereof as tuberculin and as vaccine
Buy PDF- 31pp US4976958  1990-12 Shinnick et al.  Scripps Clinic and Research Foundation Mycobacterial recombinants and peptides
Buy PDF- 9pp US5108745  1992-04 Horwitz  The Regents of the University of California Tuberculosis and legionellosis vaccines and methods for their production
Buy PDF- 6pp US5154923  1992-10 Van Eden et al.  De Staat Der Nederlanden Vertegenwoordigd Door de Minister Van Welzijn, Volksgezondheid En Cultuur Polypeptides and derivatives thereof as well as their use in pharmaceutical and diagnostic compositions
Buy PDF- 7pp US5169940  1992-12 Patarroyo   Nucleotide sequences of protein MTP40 of M. tuberculosis
Buy PDF- 7pp US5171839  1992-12 Patarroyo   Nucleotide and amino acid sequences of protein MTP40 of M. tuberculosis and synthetic peptides derived therefrom
Buy PDF- 19pp US5225324  1993-07 McFadden et al.  Bioscience International, Inc. Diagnostics for mycobacteria in public health, medical, and veterinary practice
Buy PDF- 7pp US5254459  1993-10 Patarroyo   Nucleotide and amino acid sequences of protein MTP40 of M. tuberculosis and synthetic peptides derived therefrom
Buy PDF- 6pp US5268170  1993-12 Van Eden et al.  YEDA Research and Development Co., Ltd. Methods of treatment and diagnosis of autoimmune diseases, especially arthritic conditions
       
Foreign References:
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PDF
Publication Date IPC Code Assignee   Title
Buy PDF- 48pp EP0499003 1992-08  A61K 39/00 N.V. INNOGENETICS S.A. Polypeptides and peptides, particularly recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnosis of tuberculosis 
Buy PDF- 21pp EP0519218 1992-12  A61B 10/00 BIOTECHNOLOG FORSCHUNG GMBH Hybrid-plasmid for the 38 kDa antigen from M. tuberculosis, E. coli as host, the 38 kDa antigen and a 33 kDa protein 
Buy PDF- 35pp GB2239246 1991-06  A61K 38/00 * AKTIEBOLAGET ASTRA PROTEIN ANTIGEN FROM MYCOBACTERIUM TUBERCULOSIS 
Buy PDF- 14pp WO8503639 1985-08  A61K 39/04 ROOK, Graham, Arthur, William BIOLOGICAL PREPARATIONS AND THEIR USE 
Buy PDF- 89pp WO8802027 1988-03  C12N 15/00 APPLIED BIOTECHNOLOGY, INC. GENETICALLY ENGINEERED VACCINES FOR MYCOBACTERIA 
Buy PDF- 90pp WO8805823 1988-08  A61K 39/00 WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH MYCOBACTERIUM TUBERCULOSIS GENES ENCODING PROTEIN ANTIGENS 
Buy PDF- 55pp WO8806626 1988-09  C12N 1/21 WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH RECOMBINANT MYCOBACTERIAL VACCINE 
Buy PDF- 22pp WO8905825 1989-06  A61K 39/00 IMMUNEX CORPORATION EXPRESSION OF RECOMBINANT 18/16.6 AND 15.2 kD PROTEIN ANTIGENS OF MYCOBACTERIUM LEPRAE 
Buy PDF- 43pp WO8912455 1989-12  A61K 37/02 MEDICAL RES COUNCIL STRESS PROTEINS AND USES THEREFOR 
Buy PDF- 114pp WO9000594 1990-01  C12N 1/21 ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA ... RECOMBINANT MYCOBACTERIAL EXPRESSION VEHICLES AND USES THEREFOR 
Buy PDF- 87pp WO9002564 1990-03  A61K 39/00 CODON VACCINE DIAGNOSTIC EMPLOYING PROTEINS HOMOLOGOUS TO HEAT SHOCK PROTEINS OF TRYPANOSOMA CRUZI 
Buy PDF- 86pp WO9010449 1990-09  A61K 35/12 COHEN IRUN R DIAGNOSIS AND TREATMENT OF INSULIN DEPENDENT DIABETES MELLITUS 
Buy PDF- 59pp WO9015873 1990-12  A61K 39/00 WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH VECTOR-MEDIATED GENOMIC INSERTION AND EXPRESSION OF DNA IN BCG 
Buy PDF- 229pp WO9104272 1991-04  C07K 13/00 CONTENT, Jean RECOMBINANT POLYPEPTIDES AND PEPTIDES, NUCLEIC ACIDS CODING FOR THE SAME AND USE OF THESE POLYPEPTIDES AND PEPTIDES IN THE DIAGNOSTIC OF TUBERCULOSIS 
Buy PDF- 33pp WO9114448 1991-10  A61K 38/00 AKTIEBOLAGET ASTRA NEW PROTEINS, PEPTIDES AND CORRESPONDING DNA OR RNA SEQUENCES AND PROBES USEFUL FOR DIAGNOSING TUBERCULOSIS 
Buy PDF- 82pp WO9201783 1992-02  A61K 39/04 ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA ... DNA CAPABLE OF SITE-SPECIFIC INTEGRATION INTO MYCOBACTERIA 
Buy PDF- 40pp WO9201796 1992-02  A61K 39/00 BOLLEN, Alex MYCOBACTERIAL EXPRESSION VECTOR 
Buy PDF- 25pp WO9204462 1992-03  A61K 35/14 IMMULOGIC PHARMA CORP PATHOGEN-SPECIFIC CTL THERAPY 
Buy PDF- 108pp WO9216628 1992-10  A61K 39/00 COCITO, Carlo POLYPEPTIDES FROM MYCOBACTERIUM PARATUBERCULOSIS 
Buy PDF- 64pp WO9222326 1992-12  A61K 39/04 ALBERT EINSTEIN COLLEGE OF MEDICINE, a division ... INSERTIONAL MUTATIONS IN MYCOBACTERIA 
Buy PDF- 44pp WO9221697 1992-12  C07K 7/00 HARRIS, David DIAGNOSTIC PEPTIDES DERIVED FROM M.TUBERCULOSIS ANTIGENS 
Buy PDF- 87pp WO9221376 1992-12  A61K 39/00 DELA CRUZ, Vidal INDUCTION OF CTL RESPONSES TO FOREIGN ANTIGENS EXPRESSED IN MYCOBACTERIA 
Buy PDF- 116pp WO9307897 1993-04  A61K 39/04 MEDIMMUNE, INC. BACTERIAL EXPRESSION VECTORS CONTAINING DNA ENCODING SECRETION SIGNALS OF LIPOPROTEINS 
Buy PDF- 54pp WO9314118 1993-07  C07K 7/06 ELSAGHIER, Ashraf PEPTIDE FRAGMENTS OF HSP71 OF (M. TUBERCULOSIS) AND THEIR USE IN DIAGNOSIS OF TUBERCULOSIS 
Buy PDF- 30pp WO9314789 1993-08  A61K 45/00 NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. PATHOGEN-SPECIFIC CTL THERAPY 
Buy PDF- 38pp WO9402508 1994-02  A61K 39/00 FISHLEIGH, Robert, Vincent POLYPEPTIDE ANTIGENS OF MYCOBACTERIUM BOVIS 
Buy PDF- 86pp WO9501440 1995-01  A61K 39/04 ANDERSEN, Åse, Bengaard DIAGNOSTIC SKIN TEST FOR TUBERCULOSIS 
Buy PDF- 101pp WO9501441 1995-01  A61K 39/04 ANDERSEN, AASE, BENGAARD TUBERCULOSIS VACCINE 
Buy PDF- 124pp WO9514713 1995-06  A61K 38/00 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ABUNDANT EXTRACELLULAR PRODUCTS AND METHODS FOR THEIR PRODUCTION AND USE 


Other Abstract Info: CHEMABS 128(25)304034D DERABS C1998-240107

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