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 Title: |
US6022697:
Methods for the diagnosis and treatment of insulin-dependent diabetes mellitus
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kaufman, Daniel L.; Santa Monica, CA
Tian, Jide; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2000-02-08
/ 1997-07-09
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| Application Number: |
US1997000890152
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| IPC Code: |
Advanced:
A61K 39/00;
G01N 33/564;
G01N 33/68;
Core:
more...
IPC-7:
C07K 1/00;
G01N 33/53;
G01N 33/564;
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| ECLA Code: |
A61K39/00D4; G01N33/564; G01N33/68B; S01N333/47A5; S01N800/04A; S01N800/52;
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| U.S. Class: |
Current:
435/007.24;
435/007.92;
436/501;
436/506;
530/350;
530/351;
Original:
435/007.24;
435/007.92;
436/501;
436/506;
530/351;
530/350;
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| Field of Search: |
435/7.24,7.92
436/506,501
530/351,350
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| Government Interest: |
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
This invention was made with Government support under GRANT NO. BK48455-01, awarded by NIH. The Government has certain rights in this invention.
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| Priority Number: |
| 1997-07-09 |
US1997000890152 |
| 1996-11-29 |
US1996000758414 |
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| Abstract: |
Methods for detecting the status of an insulin-dependent diabetes mellitus (IDDM)-associated autoimmune response in a mammal are provided. Specifically, the ratio of the frequency of T helper 1 cells to T helper 2 cells specific for a pancreatic beta -cell associated antigen is indicative of the status of the autoimmune response. The methods may be employed prior to the onset of the clinical symptoms of the disease, thereby allowing identification of those at risk for developing clinical symptoms of IDDM, or subsequent to pancreatic tissue transplantation, for example, to measure the efficacy of treatment directed to enhancing the lifetime of the tissue transplant. Methods for prolonging the survival of tissue transplants are also provided. Specifically, a tissue-associated antigen is administered to the mammal which serves to shift the pathogenic Th1 response associated with pathological immunity toward a protective Th2 response.
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| Attorney, Agent or Firm: |
Flehr Hohbach Test Albritton & Herbert LLP ;
Lorenz, Todd A. ;
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| Primary / Asst. Examiners: |
Saunders, David; VanderVegt, F. Pierre
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| INPADOC Legal Status: |
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