Work Files Saved Searches
   My Account                                                  Search:   Quick/Number   Boolean   Advanced   Derwent    Help   


 The Delphion Integrated View

  Buy Now:   Buy PDF- 41pp  PDF  |   File History  |   Other choices   
  Tools:  Citation Link  |  Add to Work File:    
  View:  Expand Details   |  INPADOC   |  Jump to: 
  Go to:  Derwent  
 Email this to a friend  Email this to a friend 
       
Title: US6030830: Immunoglobulin trans-spliced transcripts and uses thereof
[ Derwent Title ]


Country: US United States of America

View Images High
Resolution

 Low
 Resolution

 
41 pages

 
Inventor: Saxon, Andrew; Santa Monica, CA
Zhang, Ke; Los Angeles, CA
Fujieda, Shigeharu; Fukui, Japan

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
 News, Profiles, Stocks and More about this company

Published / Filed: 2000-02-29 / 1997-08-15

Application Number: US1997000911894

IPC Code: Advanced: C07K 16/00; C12N 15/11; A61K 38/00;
Core: more...
IPC-7: C07H 21/04; C12N 15/11; C12N 15/63;

ECLA Code: C07K16/00; C12N15/11B;

U.S. Class: Current: 435/320.1; 536/023.1; 536/024.1; 536/024.31;
Original: 435/320.1; 536/023.1; 536/024.1; 536/024.31;

Field of Search: 435/006,69.1,69.7,172.3,328,372.3,320.1,375 530/387.3,387.1 536/23.1,23.4,24.1,24.31,24.33,24.5 514/044

Government Interest:     The government owns certain rights in the present invention pursuant to grant number AI-15251 from the U.S. Public Health Service and grant number AI-34567 from the National Institutes of Allergy and Infectious Diseases, and Environmental Health Science.

Priority Number:
1997-08-15  US1997000911894
1996-08-19  US1996000023579P

Abstract: Compositions and methods for directing the synthesis of a particular human immunoglobulin isotype are provided. Nucleic acid molecules representing sense and antisense sequences of trans-spliced messenger ribonucleic acid molecules enhance or reduce, respectively, isotype recombination to IgE, IgA or IgG isotypes from an IgM isotype. Particular methods and compositions for the treatment of allergy and allergic reaction are described through inhibition of IgE.

Attorney, Agent or Firm: Mandel & Adriano ;

Primary / Asst. Examiners: LeGuyader, John L.; Shibuya, Mark L.

Maintenance Status: E2 Expired  Check current status

INPADOC Legal Status: Show legal status actions          Buy Now: Family Legal Status Report

Parent Case:     The present application claims benefit of U.S. Provisional Application No: 60/023,579, filed Aug. 19, 1996.

Designated Country: AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE EP ES FI GB GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV 

Family: Show 3 known family members

First Claim:
Show all 5 claims
What is claimed is:     1. A purified nucleic acid molecule having a nucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 13, or SEQ ID NO: 15.

Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 1 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (1)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 128(19)229359H DERABS C1998-179050

Other References:
  • Branch. TIBS. 23, 45-50 (Feb. 1998).
  • Gewirtz et al. PNAS. 93. 3161-3163 (Apr. 1996).
  • Rojanasakul. 18. 115-131 (Jan. 1996).
  • Mastrangelo et al. Seminars in Oncology 23, 4-21 (Feb. 1996). (18 pages) Cited by 143 patents [ISI abstract]
  • Golub. The Cellular Basis of the Immune Response. pp. 197-203 (1981).
  • Berdoz, et al., "Specific Amplification By PCR of Rearranged Genomic Variable Regions of Immunoglobulin Genes From Mouse Hybidoma Cells," Research, 4(5) :256-264, 1995. (9 pages) Cited by 2 patents [ISI abstract]
  • Bottaro, et al., "S Region Transcription per se Promotes Basal IgE Class Switch Recombination But Additional Factors Regulate the Efficiency of the Process," EMBO Journal, 13(3) :665-674, 1994. (10 pages) Cited by 2 patents [ISI abstract]
  • Chan, et al., "Expression of IgE From A Nonrearranged ε Locus In Cloned B-Lymphoblastoid Cells That Also Express IgM," Journal of Immun., 144(9) :3563-3568, May 1990. (6 pages)
  • Chen, et al., "Double Isotype Production By A Neoplastic B Cell Line. Allelically Excluded Production of µ and γ1 Heavy Chains Without Ch Gene Rearrangement," J. Exp. Med., 164:562-579, Aug. 1986. (18 pages)
  • Cheong, C., & P.B. Moore, "Solution Structure of An Unusually Stable RNA Tetraplex Containing G- and U-Quartet Structures," Biochemistry, 31:8406-8414, 1992. (9 pages) Cited by 2 patents [ISI abstract]
  • Chiara, M.D., & R. Reed, "A Two-Step Mechanism for 5| and 3| Splice-Site pairing," Nature, 375:510-513, Jun. 1995. (4 pages) Cited by 2 patents [ISI abstract]
  • Diaz-Sanchez, et al., "Diesel Exhaust Particles Induce Local IgE Production in Vivo and After the Pattern of IgE Messenger RNA Isoforms," J. Clin. Invest., 94:1417-1425, Oct. 1994. (9 pages) Cited by 2 patents [ISI abstract]
  • Ellison, J., & L. Hook, "Linkage and Sequence Homology of Two Human Immunoglobulin γ Heavy Chain Constant Region Genes," proc. Natl. Acad. Sci. USA, 79:1984-1988, Mar. 1982. (5 pages) Cited by 17 patents
  • Fujieda, et al., "Multiple Types of Chimeric Germ-Line Ig Heavy-Chain Transcripts in Human B Clls: Evidence for Trans-Splicing of Human Ig RNA," Journal of Immun., 157:3450-3459, 1996. (10 pages) Cited by 2 patents [ISI abstract]
  • Fujieda, et al., "IL-4 Plus CD40 Monoclonal Antibody Induces Human B Cells γ Subclass-Specific Isotype Switch: Switching to γ1, γ3, and γ4, But Not γ2," J. of Immun., 2318-2328, 1995. (11 pages) [ISI abstract]
  • Gaff, C., & S. Gerondakis, "RNA Splicing Generates Alternate Forms of Germline Immunoglobulin α Heavy Chain Transcripts,"Int. Immun., 2(12) :1143-1148, 1990. (6 pages)
  • Gerstein, et al., "Isotype Switching of An Immunoglobulin Heavy Chain Transgene Occurs By DNA Recombination Between Different Chromosomes," Cell, 63:537-548, Nov. 1990. (12 pages) Cited by 15 patents
  • Han, et al., "Regulated Expression of Immunoglobulin Trans-mRNA Consisting of the Variable Region of a Transenic µ Chain and Constant Regions of Endogenous Isotypes," International Immunology, 3(12) :1197-1206, Aug. 1991. (10 pages) [ISI abstract]
  • Harriman, et al, "Immunoglobulin Class Switch Recombination," Annu. Rev. Immunol., 11:361-384, 1993. (24 pages) Cited by 4 patents [ISI abstract]
  • Harriman, et al., "Class Switch in Iα Exon-Deficient Mice," J. Clin. Invest., 97(2) :477-485, Jan. 1996. (9 pages) [ISI abstract]
  • Jung, et al., "Shutdown of Class Switch Recombination By Deletion of a Switch Region Control Element," Science, 259:984-987, Feb. 1993. (4 pages) Cited by 17 patents [ISI abstract]
  • Kim, et al., "Probing the Structure of a Putative Intermediate in Homologous Recombination: The Third Strand in the Parallel DNA Triplex is in Contact With the Major Groove of the Duplex," J. Mol. Biol., 247:874-889, 1995. (16 pages) Cited by 3 patents [ISI abstract]
  • Kim, et al., "Tetramerization of An RNA Oligonucleotide Containing a GGGG Sequence," Nature, 351:331-332, May 1991. (2 pages) Cited by 5 patents [ISI abstract]
  • Kitani, A., & W. Strober, "Regulation of Cγ Subclass Germ-Line Transcripts in Human Peripheral Blood B Cells," J. of Immun., 151(7) :3478-3488, Oct. 1991.
  • Knight, et al., "Transchromosomally Derived Ig Heavy Chains," J. of Immun., 684-691, 1995. (8 pages) [ISI abstract]
  • Kumimoto, et al., "Molecular Analysis of Double Isotype Expression in IgA Switching," Journal of Immun., 150(4) :1338-1347, Feb. 1991.
  • Li, et al., "Expression of Iµ -Cγ Hybrid Germline Transcripts Subsequent to Immunoglobulin Heavy Chain Class Switching," Int. Immun., 6(4) :491-497, 1993.
  • Lorenz, et al., "Switch Transcripts in Immunoglobulin Class Switching," Science, 267:1825-1828, Mar. 1995. (4 pages) [ISI abstract]
  • Lutzker, S., & F.W. Alt, "Structure and Expression of Germ Line Immunoglobulin γ2b Transcripts," Molecular & Cellular Biology, 8(4) :1849-1852, Apr. 1988. (4 pages) Cited by 15 patents
  • Lutzker, et al., "Mitogen- and IL-4-Regulated Expression of Germ-Line Ig γ2b Transcripts: Evidence for Directed Heavy Chain Class Switching," Cell, 53:177-184, Apr. 1988. (8 pages)
  • MacKenzie, T., & H.M.Dosch, "Clonal and Molecular Characteristics of the Human IgE-Committed B Cell Subset," J. Exp. Med., 169:407-430, Feb. 1989. (24 pages)
  • Kinashi, et al., "Human Neoplastic B Cells Express More Than Two Isotypes of Immunoglobulins Without Deletion of Heavy-Chain Constant-Region Genes," Genes & Development, 1:465-470, 1987. (6 pages)
  • Max, et al., "Duplication and Deletion in the Human Immunoglobulin ε Genes," Cell, 29:691-699, 1982. (9 pages) Cited by 3 patents
  • Mills, et al., "Sequences of Human Immunoglobulin Switch Regions: Implications For Recombination and Transcription," Nucleic Acids Res., 18(24) :7305-7316, 1990. (12 pages) Cited by 4 patents
  • Morgan, A. Richard, "Three-Stranded (triplex) DNAs (RNAs) : Do they Have a Role in Biology?" Indian J. of Biochem. & Biophysics, 31:83-87, Apr. 1994. (5 pages) [ISI abstract]
  • Neale, G.A.M., & G.R. Kitchingman, "mRNA Transcripts Initiating Within the Human Immunoglobulin mu Heavy Chain Enhancer Region Contain a Non-Translatable Exon and Are Extremely Heterogeneous at the 5 | End," Nucleic Acids Res., 19(9) :2427-2433, 1991. (7 pages) [ISI abstract]
  • Nolan-Willard, et al., "Coexpression of µ and γ1 Heavy Chains Can Occur by a Discontinuous Transcription Mechanism From the Same Unrearranged Chromosome," Proc. Natl. Acad. Sci. USA, 89:1234-1238, Feb. 1992. (5 pages) [ISI abstract]
  • Perlmutter, A.P., & W. Gilbert, "Antibodies of the Secondary Response Can Be Expressed Without Switch Recombination in Normal Mouse B Cells," Proc. Natl. Sci. USA, 81:7189-7193, Nov. 1984. (5 pages)
  • Ravetch, et al., "Structure of the Human Immunoglobulin µ Locus: Characterization of Embryonic and Rearranged J and D Genes," Cell, 27:583-591, Dec. 1991.
  • Rothman, et al., "Structure and Expression of Germ Line Immunoglobulin Heavy-Chain ε Transcripts: Interleukin-4 Plus Lipopolysaccharide-Directed Switching to Cε," Molecullar & Cellular Biology, 10(4) :1672-1679, Apr. 1990. (8 pages) Cited by 6 patents
  • Sen, D., & W. Gilbert, "A Sodium-Potassium Switch in the Formation of Four-Stranded G4-DNA," Nature, 344:410-414, Mar. 1990. (5 pages) Cited by 11 patents
  • Shapira, et al., "Deletional Switch Recombination Occurs in Interleukin-4-Induced Isotype Switching to IgE Expression by Human B Cells," Proc. Natl. Acad. Sci. USA, 88:7528-7532, Sep. 1991. (5 pages) [ISI abstract]
  • Shimizu, et al., "Immunoglobulin Double-Isotype Expression by Trans-mRNA in a Human Immunoglobulin Transgenic Mouse," Proc. Natl. Acad. Sci. USA, 86:8020-8023, Oct. 1989. (4 pages) Cited by 25 patents
  • Shimizu, et al., "Trans-Splicing As a Possible Molecular Mechanism for the Multiple Isotype Expression of the Immunoglobulin Gene," J. Exp. Med., 173:1385-1393, Jun. 1991. (9 pages) Cited by 18 patents [ISI abstract]
  • Shimizu, A., & T. Honjo, "Synthesis and Regulation of Trans-mRNA Encoding the Immunoglobulin l Heavy Chain," FASEB J., 7:149-154, Jan. 1993. (6 pages) Cited by 2 patents [ISI abstract]
  • Sideras, et al., "Production of Sterile Transcripts of Cγ Genes In An IgM-Producing Human Neoplastic B Cell Line That Switches To IgG-Producing Cells," International Immun., 1(6) :631-642, Oct. 1989.
  • Sklenar, V., & J. Feigon, "Formation of a Stable Triplex From a Single DNA Strand," Nature, 345:836-838, Jun. 1990. (3 pages)
  • Stavnezer, et al., "Immunoglobulin Heavy-Chain Switching May Be Directed By Prior Indction of Transcripts From Constant-Region Genes," Proc. Natl. Acad. Sci. USA, 85:7704-7708, Oct. 1988. (5 pages) Cited by 17 patents
  • Stavnezer-Nordgren, J., & S. Sirlin, "Specificity of Immunoglobulin Heavy Chain Switch Correlates With Activity of Germline Heavy Chain Genes Prior to Switching," EMBO Journal, 5(1) :95-102, 1986. (8 pages)
  • Van Meervelt, et al., "High-Resolution Structure of a DNA Helix Forming (C=G) *G Base Triplets," Nature, 374:742-744, 1995. (3 pages) [ISI abstract]
  • Xu, et al., "Replacement of Germ-Line ε Promoter By Gene Targeting Alters Control of Immunoglobulin Heavy Chain Class Switching," Proc. Natl. Acad. Sci. USA, 90:3705-3709, Apr. 1993. (5 pages) Cited by 7 patents [ISI abstract]
  • Yaoita, et al., "Expression of Lymphocyte Surface IgE Does Not Require Switch Recombination," Nature, 297:697-699, Jun. 1982. (3 pages)
  • Zhang, et al., "Two Unusual Forms of Human Immunoglobulin E Encoded by Alternative RNA Splicing of ε Heavy Chain Membrane Exons," J. Exp. Med., 176:233-243, Jul. 1992. (11 pages) Cited by 2 patents [ISI abstract]
  • Zhang, et al., "Switch Circles From IL-4 Directed ε Class Switching From Human B Lymphocytes," J. Immun., 3427-3435, 1994. (9 pages) [ISI abstract]
  • Zhang, et al., "A Selective Defect in IgG2b Switching as a Result of Targeted Mutation of the 1γ2b Promoter and Exon," EMBO Journal, 12(9) :3529-3537, 1993. (9 pages) Cited by 2 patents [ISI abstract]
  • Zhurkin, et al., "A Parallel DNA Triplex As a Model for the Intermediate in Homologous Recombination," J. Mol. Biol., 239:181-200, 1994. (20 pages) Cited by 14 patents [ISI abstract]
  • Gauchat, et al., "Structure and Expression of Germline ε Transcripts in Human B Cells Induced by Interleukin 4 to Switch to IgE Production," J. Exp. Med., 172:463-473, Aug. 1991.
  • Zhang, et al., "CD40 Stimulation Provides An IFN-γ-Independent and IL-4-Dependent Differentiation Signal Directly To Human B Cells for IgE Production," J. of Immun., 146(6) :1836-1842, Mar. 1991. (7 pages) Cited by 19 patents [ISI abstract]


  • Inquire Regarding Licensing

    Powered by Verity


    Plaques from Patent Awards      Gallery of Obscure PatentsNominate this for the Gallery...

    Thomson Reuters Copyright © 1997-2010 Thomson Reuters 
    Subscriptions  |  Web Seminars  |  Privacy  |  Terms & Conditions  |  Site Map  |  Contact Us  |  Help