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 Title: |
US6033864:
Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Braun, Jonathan; Tarzana, CA
Cohavy, Offer; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2000-03-07
/ 1998-03-12
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| Application Number: |
US1998000041889
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| IPC Code: |
Advanced:
A61K 38/17;
C07K 14/245;
C07K 16/12;
C07K 16/18;
G01N 33/68;
Core:
C07K 14/195;
more...
IPC-7:
G01N 33/53;
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| ECLA Code: |
A61K38/17A2; C07K14/245; C07K16/12A26A; C07K16/18; G01N33/68V; M07K203/00; S01N800/06B;
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| U.S. Class: |
Current:
435/007.1;
435/007.24;
Original:
435/007.1;
435/007.24;
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| Field of Search: |
435/7.24,7.32
436/506,508
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| Government Interest: |
ACKNOWLEDGMENT
This work was supported by grant number DK46763 awarded by the National Institutes of Health and by grant number GM08042 awarded by the National Institutes of Health. The United States government has certain rights in this invention.
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| Priority Number: |
| 1998-03-12 |
US1998000041889 |
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| Abstract: |
The present invention relates to microbial UC pANCA antigens. The invention provides methods of diagnosing ulcerative colitis (UC) and methods of inducing tolerance in a pANCA-positive patient with UC using a histone H1-like antigen. The invention further provides methods of diagnosing UC and methods of inducing tolerance in a pANCA-positive patient with UC using a porin antigen. Methods of diagnosing UC and methods of inducing tolerance in a pANCA-positive patient with UC using a Bacteroides antigen also are provided.
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| Attorney, Agent or Firm: |
Campbell & Flores LLP ;
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| Primary / Asst. Examiners: |
Saunders, David;
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| Maintenance Status: |
CC Certificate of Correction issued
View Certificate of Correction
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
This application is a continuation-in-part of application Ser. No. 08/837,058, filed Apr. 11, 1997, the entire contents of which are incorporated herein by reference and which claims priority to application Ser. No. 08/630,671, filed Apr. 12, 1996, which was converted to provisional application Ser. No. 60/057,846, now abandoned.
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| Designated Country: |
AE AL AM AP AZ BA BB BG BR BY CA CN CU CZ EA EE GD GE GH GM HR HU ID IL IN IS AT BE CH DE DK ES FI FR GB GR IE IT
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| Family: |
Show 14 known family members
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First Claim:
Show all 15 claims |
We claim:
1. A method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease, comprising:
- (a) obtaining a sample from said subject;
- (b) contacting said sample with a porin antigen having an amino acid sequence selected from the group consisting of SEQ ID NOS: 28 to 30, or a modification or fragment thereof having immunological reactivity with pANCA, under conditions suitable to form a complex of said porin antigen, or modification or fragment thereof, with antibody to said porin antigen; and
- (c) detecting the presence or absence of said complex, wherein the presence of said complex indicates that said subject has UC.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 6 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 131(17)223471D
CHEMABS 132(16)206929N
CHEMABS 132(16)206929N
DERABS C2000-255695
DERABS C1999-551215
DERABS C2000-255695
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| Other References: |
Brandwein et al., "Spontaneously Colitic C3H/HeJBir Mice Demonstrate Selective Antibody Reactivity to Antigens of the Enteric Bacterial Flora," The Journal of Immunology 159:44-52 (1997).
(9 pages)
Cited by 6 patents
[ISI abstract]
Breeling et al., "Bacteroides vulgatus Outer Membrane Antigens Associated with Carrageenan-Induced Colitis in Guinea Pigs," Infection and Immunity 56:1754-1759 (1988).
(6 pages)
Cited by 2 patents
Cong et al., "CD4+ T Cells Reactive to Enteric Bacterial Antigens in Spontaneously Colitic C3H/HeJBir Mice: Increased T Helper Cell Type 1 Response and Ability to Transfer Disease," J. Exp. Med. 187:855-864 (1998).
(10 pages)
Cited by 8 patents
[ISI abstract]
Delcour, "Function and modulation of bacterial porins: insights from electrophysiology," FEMS Microbiology Letters 151:115-123 (1997).
(9 pages)
Cited by 2 patents
[ISI abstract]
Duchene et al., "Sequence and Transcriptional Start Site of the Pseudomonas aeruginosa Outer Membrane Porin Protein F Gene," Journal of Bacteriology 170:155-162 (1988).
(8 pages)
Cited by 5 patents
Duchmann, et al., "Bacteria-Specific T-Cell Clones are Selective in their Reactivity Towards Different Enterobacteria or H. Pylori and Increased in Inflammatory Bowel Disease," Scand. J. Immunol. 44:71-79 (1996).
(9 pages)
Cited by 2 patents
[ISI abstract]
El-Zaatari et al., "Identification and Characterization of Mycobacterium paratuberculosis Recombinant Proteins Expressed in E. coli," Current Microbiology 29:177-184 (1994).
(8 pages)
[ISI abstract]
Herfarth et al., "Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers," Gut 39:836-845 (1996).
(10 pages)
Cited by 5 patents
[ISI abstract]
Lu et al., "Generation and characterization of novel antibodies highly selective for phosphorylated linker histone H1 in Tetrahymena and HeLa Cells," Chromosoma 103:111-121 (1994).
(11 pages)
Cited by 2 patents
[ISI abstract]
Macpherson et al., "Mucosal antibodies in inflammatory bowel diseases are directed against intestinal bacteria," Gut 38:365-375 (1996).
(11 pages)
Cited by 3 patents
[ISI abstract]
Muller et al., "Immunogenicity of Free Histones and of Histones Complexed with RNA," Molec. Immunol. 28:763-772 (1991).
(10 pages)
Cited by 2 patents
[ISI abstract]
Paraseghian et al., "Characterization of a set of antibodies specific for three human histone H1 subtypes," Chromosoma 103:198-208 (1994).
Parseghian et al., "A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences," Protein Science 3:575-587 (1994).
(13 pages)
Cited by 2 patents
[ISI abstract]
Poxton et al., "Mucosa-associated bacterial flora of the human colon," J. Med. Microbiol. 46:85-91 (1997).
(7 pages)
Cited by 2 patents
[ISI abstract]
Rath et al., "Normal Luminal Bacteria, Especially Bacteroides Species, Mediate Chronic Colitis, Gastritis, and Arthritis in HLA-B27/Human β2 Microglobulin Transgenic Rats," The Journal of Clinical Investigation 98:945-953 (1996).
(9 pages)
Cited by 2 patents
[ISI abstract]
Reumaux et al., "Distinct Production of Autoantibodies to Nuclear Components in Ulcerative Colitis and in Crohn's Disease," Clin. Immunol. and Immunopath. 77:349-357 (1995).
(9 pages)
Cited by 2 patents
[ISI abstract]
Rowbotham et al., "Peripheral cell-mediated immune response to mycobacterial antigens in inflammatory bowel disease," Clin. Exp. Immunol. 102:456-461 (1995).
(6 pages)
Cited by 2 patents
[ISI abstract]
Sartor, "Pathogenesis and Immune Mechanisms of Chronic Inflammatory Bowel Diseases," The American Journal of Gastroenterology 92:5S-11S (1997).
(7 pages)
Cited by 15 patents
[ISI abstract]
Saxon et al., "A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease," J. Allergy Clin. Immunol. 86:202-210 (1990).
(9 pages)
Cited by 17 patents
Sobajima et al., "Novel Autoantigens of Perinuclear Antineutrophil Cytoplasmic Antibodies (P-ANCA) in Ulcerative Colitis: Non-histone Chromosomal Proteins, HMG1 and HMG2," Clinical and Experimental Immunology 107:135-140 (1997).
(6 pages)
Cited by 12 patents
[ISI abstract]
Weiner et al., "Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Adminstration of Autoantigens," Ann. Rev. Immunol. 12:809-837 (1994).
(29 pages)
Cited by 48 patents
[ISI abstract]
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(6 pages)
Cited by 3 patents
[ISI abstract]
Wexler, "Pore-Forming Molecules in Gram-Negative Anaerobic Bacteria," Clinical Infectious Diseases 25 (Suppl 2) :S284-S286 (1997).
(3 pages)
Cited by 2 patents
[ISI abstract]
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| Continuity Data: |
| Application Number | Filed | Notes |
|---|
|
|
US1998000041889 | 1998-03-12 | is a
related to the prior publication |
| |
US20030092080A1 issued 2003-05-15 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
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|
|
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US2002000229567 | 2002-08-27 | is a
continuation of |
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US1999000417264
| 1999-10-12 |
(pending)
[presumed granted]
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| |
US6537768 issued 2003-03-25 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC panca antigens
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|
|
|
US2002000229567 | | is a
continuation of |
|
US1999000417264
| 1999-10-12 |
|
| |
US6537768 issued 2003-03-25 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC panca antigens
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|
|
|
US1999000417264 | 1999-10-12 | is a
continuation of |
|
>US1998000041889<
| 1998-03-12 |
(granted)
|
| |
US6033864 issued 2000-03-07 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
|
|
|
|
US1999000417264 | | is a
continuation of |
|
>US1998000041889<
| 1998-03-12 |
|
| |
US6033864 issued 2000-03-07 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
|
|
|
|
>US1998000041889< | 1998-03-12 | is a
continuation in part of |
|
US1997000837058
| 1997-04-11 |
(granted)
|
| |
US6074835 issued 2000-06-13 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1
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|
|
|
>US1998000041889< | | is a
continuation in part of |
|
US1997000837058
| 1997-04-11 |
|
| |
US6074835 issued 2000-06-13 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1
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|
|
|
US1998000041889 | 1998-03-12 | is a
non-provisional of provisional |
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US1996000057846P
| 1996-04-12 |
|
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