 |
|
|
|
|
|
 Title: |
US6040293:
Clavanins
[ Derwent Title ]
|
| Country: |
US United States of America
|
| |
| Inventor: |
Lehrer, Robert I.; Santa Monica, CA
Zhao, Chengquan; Los Angeles, CA
Lee, In-Hee; Seoul, Republic of Korea
|
| Assignee: |
The Regents of the University of California, Los Angeles, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
News, Profiles, Stocks and More about this company
|
| Published / Filed: |
2000-03-21
/ 1997-02-28
|
| Application Number: |
US1997000810324
|
| IPC Code: |
Advanced:
C07K 14/435;
C12N 1/21;
C12N 15/12;
A61K 38/00;
Core:
more...
IPC-7:
A61K 37/02;
C07K 14/00;
|
| ECLA Code: |
C07K14/435A;
|
| U.S. Class: |
Current:
514/013;
530/326;
Original:
514/013;
530/326;
|
| Field of Search: |
514/013,21
530/326,323,332
|
| Government Interest: |
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT
This invention was made at least in part with funding from NIH grant numbers 1-PO1-AI-37945-01 and 5R37-AI-22839-10. The U.S. Government has certain rights in this invention.
|
| Priority Number: |
|
| Abstract: |
Novel microbial peptides called clavanins are of the formula
[X'1 X2 B'3 X4 X5 ]U6 B7 X8 X9 B10 B11 X12 U13 Z14 X15 X16 B*17 U18 X19 U20 B21 X22 X23 ( 1)(SEQ ID NO:1)
including the salts, esters, amides and acylated forms thereof
- wherein X is a hydrophobic amino acid residue or modified form thereof;
- X' is a small or a hydrophobic amino acid residue or a modified form thereof;
- B is a basic amino acid residue or modified form thereof;
- B' is basic or a polar/large amino acid residue or modified form thereof; and
- B* is a basic or a hydrophobic amino acid residue or a modified form thereof;
- U is a small amino acid residue or modified form thereof;
- Z is a polar/large amino acid residue or modified form thereof, and wherein 1-5 amino acids is deleted from the N-terminus.
|
| Attorney, Agent or Firm: |
Morrison & Foerster LLP ;
|
| Primary / Asst. Examiners: |
Carlson, Karen Cochrane;
|
| Maintenance Status: |
E1 Expired Check current status
|
| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
|
|
|
|
|
|
|
| Parent Case: |
This is a continuation-in-part of U.S. Ser. No. 08/746,160, filed Nov. 6, 1996 from which priority is claimed, and the contents of which are incorporated herein by reference.
|
| Designated Country: |
CA EP JP
|
| Family: |
Show 4 known family members
|
First Claim:
Show all 16 claims |
We claim:
1. A compound in isolated form of the formula
X'1 X2 B'3 X4 X5 U6 B7 X8 X9 B10 B11 X12 U13 Z14 X15 X16 B*17 U18 X19 U20 B21 X22 X23 ( 1) (SEQ ID NO:1)
including the salts, esters, amides, and acylated forms thereof,
- said compound having antimicrobial activity and an α-helical conformation,
- wherein X is a hydrophobic amino acid residue selected from the group consisting of Tyr, Val, Ile, Leu, Met, Phe, and Trp;
- X' is a small or a hydrophobic amino acid residue selected from the group consisting of Gly, Ser, Ala, Thr, Tyr, Val, Ile, Leu, Met, Phe, and Trp;
- B is a basic amino acid residue selected from the group consisting of Arg, Lys, and His;
- B' is a basic or a polar/large amino acid residue selected from the a group consisting of Arg, Lys, His, Asn, and Gln;
- B* is a basic or a hydrophobic amino acid residue selected from the group consisting of Arg, Lys, His, Tyr, Val, Ile, Leu, Met, Phe, and Trp;
- U is a small amino acid residue selected from the group consisting of Gly, Ser, Ala, and Thr;
- Z is a polar/large amino acid residue selected from the group consisting of Asn and Gln; and
- wherein one or more X'1 X2 B'3 X4 X5 may be truncated.
|
| Background / Summary: |
Show background / summary
|
| Drawing Descriptions: |
Show drawing descriptions
|
| Description: |
Show description
|
|
|
|
|
|
|
| U.S. References: |
Go to Result Set:
No U.S. references
| No patents reference this one
|
Backward references (0)
|
|
Nominate this for the Gallery...
