 |
|
|
|
|
|
 Title: |
US6043223:
Enhanced opening of abnormal brain tissue capillaries
[ Derwent Title ]
|
| Country: |
US United States of America
|
| |
| Inventor: |
Black, Keith L.; Los Angeles, CA
|
| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
News, Profiles, Stocks and More about this company
|
| Published / Filed: |
2000-03-28
/ 1997-11-12
|
| Application Number: |
US1997000968169
|
| IPC Code: |
Advanced:
A61K 38/04;
Core:
more...
IPC-7:
A61K 38/00;
A61K 38/08;
|
| ECLA Code: |
A61K38/04E+M;
|
| U.S. Class: |
Current:
514/015;
435/375;
514/017;
514/048;
514/079;
514/263.37;
536/026.11;
Original:
514/015;
514/261;
514/079;
514/048;
514/017;
536/026.11;
435/240.242;
435/240.243;
435/240.241;
435/240.23;
435/240.24;
|
| Field of Search: |
514/015,17
435/240.242,240.243,240.241,240.23,240.24
536/26.11
|
| Government Interest: |
This invention was made with Government support under Grant No. NS25554 and Grant No. NS32103 awarded by the National Institute of Health (NIH). The Government has certain rights in this invention.
|
| Priority Number: |
| 1997-11-12 |
US1997000968169 |
|
| Abstract: |
Improved compositions and methods for increasing permeability of abnormal brain tissue to pharmaceutical agents. Cyclic GMP specific phosphodiesterase inhibitors are combined with bradykinin or a bradykinin analog to provide enhanced permeability of brain capillaries which is limited to abnormal brain tissue. Neuropharmaceutical and neurodiagnostic agents introduced into the bloodstream are directed selectively to the abnormal brain tissue. The pharmaceutical preparation composed of bradykinin or a bradykinin analog and a cyclic GMP specific phosphodiesterase inhibitor may be administered either intravenously or directly into the carotid artery.
|
| Attorney, Agent or Firm: |
Oppenheimer Wolff & Donnelly ;
|
| Primary / Asst. Examiners: |
Moezie, F. T.;
|
| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
|
| Designated Country: |
AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EA EE EP ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK
|
| Family: |
Show 7 known family members
|
First Claim:
Show all 20 claims |
What is claimed is:
1. The pharmaceutical preparation adapted for use in increasing the selective permeability of abnormal brain tissue capillaries of a patient, said preparation comprising:
- bradykinin or a bradykinin analog;
- cyclic GMP specific phosphodiesterase inhibitor; and
- a sufficient amount of a pharmaceutically acceptable carrier to provide a pharmaceutical preparation which can be introduced into the blood stream of a mammal wherein the concentration of bradykinin or bradykinin analog in said pharmaceutical preparation is between 10 µg/ml to 50 mg/ml and the concentration of cyclic GMP specific phosphodiesterase between 1 mg/ml and 15 mg/ml.
|
| Background / Summary: |
Show background / summary
|
| Drawing Descriptions: |
Show drawing descriptions
|
| Description: |
Show description
|
